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Use and Effects of Drugs
Stimulants, Depressants, Mental Health, Alcohol and Caffeine
223
Health Care
Undergraduate 3
11/06/2013

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Term
Increase activity throughout the body
Definition
Stimulants
Term
substances that keep a person going mentally and physically
Definition
Stimulants
Term
Examples of restricted stimulants
Definition
Cocaine and amphetamine
Term
Examples of readily available stimulants
Definition
Caffeine and nicotine
Term
POWERED COCAINE IS TOO STABLE TO BE SMOKED
Definition
TRUE
Term
Bush that produces cocaine
Definition
Coca
Term
Natives of the Andes
Definition
chewed coca leaves to give them greater strength and endurance
Term
The coca leaf was an important part
Definition
Inca culture
Used in religious ceremonies and as currency
Term
Used coca leaf extract in many products including
Definition
lozenges, tea, and, especially, wine
Term
Cocaine is used medically today as
Definition
numbing agent
Term
medical derivative of cocaine
Definition
novocain
used by dentists
Term
Experimented with ability of cocaine to produce local anesthesia
Definition
Dr. W. S. Halsted – had a cocaine addiction
Term
Cocaine was isolated before
Definition
1860
Term
Studied use of cocaine as a treatment for depression and morphine dependence
Definition
Sigmund Freud – had a cocaine issue, used it with his patients
Term
Negative publicity about cocaine influenced the passage of the
Definition
1914 Harrison Act
Term
Delivered cocaine via newly developed hypodermic syringe
Definition
Dr. W. S. Halsted
Term
In Columbia selling coca paste is
Definition
15% more profitable than selling any other produce
Term
Cocaine paste is made using
Definition
gasoline, sulfuric acid, ammonia and other harmful ingredients
Term
what farmer actually produce in Bolivia, Peru and other places
Definition
Coca paste
Term
what we are most familiar with; powder
Definition
Cocaine hydrochloride
Term
Crude extract created during the manufacture of cocaine
Definition
Coca paste
Term
Can be mixed with tobacco and smoked
Definition
Coca paste
Term
Most common form of pure cocaine
Definition
Cocaine hydrochloride
Term
Stable water-soluble salt
Definition
Cocaine hydrochloride
Term
Cannot smoke it, must be transformed into another base in order to be smoked
Definition
Cocaine hydrochloride
Term
Freebase
Definition
Smokable cocaine version
Term
Cheaper form of freebase
Definition
Crack or Rock Cocaine
Term
Lumps of dried, smokable cocaine
Definition
Crack or Rock Cocaine
Term
Prior to _____, the major form of the drug available was cocaine hydrochloride, which was snorted
Definition
1985
Term
Crack cocine became available in
Definition
1980s
Term
______ cocaine has a greater abuse potential than ______ cocaine
Definition
Smoked; Snorted
Term
Laws created about cocaine
Definition
Anti-Drug Abuse Acts of 1986 and 1988
Term
Crack cocaine's high
Definition
15 minutes
Term
Cocaine's high
Definition
30 minutes
Term
Cocaine blocks
Definition
reuptake of dopamine, serotonin, and norepinephrine
Term
Chewing or sucking coca leaves
Definition
Minor effects
Slow absorption and onset of effects
Term
“Snorting” through nasal mucous membranes
Definition
Not as fast as inhalation or injection
Rapid absorption and onset of effects
Term
Injected intravenously
Definition
Rapid and brief effects
Term
Smoked
Definition
Most rapid and brief effects
Term
Cocaine is metabolized by
Definition
enzymes in the blood and liver
Term
Cocaine has a half-life of about
Definition
1 hour
Term
Local anesthetic properties of cocaine were discovered in
Definition
1860
Term
Cocaine remains in use for surgery in the
Definition
nasal, laryngeal, and esophageal regions
Term
Acute cocaine toxicity causes profound CNS stimulation, which can lead to
Definition
respiratory or cardiac arrest
Term
Cocaine combined with alcohol can cause the formation of the toxic chemical
Definition
cocaethylene
Term
Risks of regularly snorting cocaine
Definition
Damage to the nasal septum
Paranoid psychosis
Damage to the heart muscle
Term
Dependence is not guaranteed with
Definition
Stimulants
Term
Type of dependence typical with stimulants
Definition
psychological dependence
Term
1980s Crack Babies
Definition
Infants born to mothers that used during pregnancy
Didn’t ever have cognitive or learning disabilities
Born small, but caught up by the time they were 2
Term
Cocaine Relapse
Definition
Can be great because it is so rewarding for the user
Feel depressed because they are not getting pleasure from the drug
Term
Street cocaine averages about ______ percent pure
Definition
50-75
Term
Most illicit cocaine comes from
Definition
Peru, Bolivia, and Columbia
Term
about __ percent of adults currently use cocaine
Definition
2
Term
Ephedrine is a
Definition
Sympathomimetic drug
Stimulates the sympathetic branch of the autonomic nervous system
Term
Use by soldiers in World War II to fight fatigue
Definition
Amphetamine
Term
Amphetamine + heroin injected together =
Definition
Speedball
Term
Manufacture of methamphetamine is dangerous and associated with
Definition
toxic fumes and residue
Term
Methamphetamine abuse began in the ______ US and
Definition
western US and spread east
Term
Methamphetamine vs. Cocaine
Definition

Methamphetamine 

Stimulant

Man-made

Long-lasting high

50% of drug is removed in 12 hours

Increases dopamine release and blocks re-uptake

Limited medical use

 

Cocaine

Stimulant & local anesthetic

Plant-derived

Brief high

50% of drug is removed in 1 hour

Blocks dopamine re-uptake

Limited medical use

Term
designed to slow the system down
Definition
Depressants
Term
Include prescription drugs that treat anxiety (sedatives) and insomnia (hypnotics)
Definition
Depressants
Term
Also called sedative-hypnotics
Definition
Depressants
Term
the most widely used depressant
Definition
alcohol
Term
the most widely prescribed depressants
Definition
Benzodiazepines
Term
Volatile solvents and other compounds used for intoxicating purposes
Definition
Inhalants
Term
Have depressant effects similar to sedative-hypnotics
Definition
Inhalants
Term
“knockout drops,” “Mickey Finn”
Definition
Chloral hydrate
Term
the first barbiturate to be used clinically
Definition
1903: Barbital (Veronal)
Term
Low-dose Barbiturates
Definition
long-acting forms used for daytime relief of anxiety
Term
Higher-dose Barbiturates
Definition
shorter-acting forms used to induce sleep
Term
Short-acting Barbiturates
Definition
Time of onset: 15 minutes
Duration of action: 2 to 3 hours
Term
Intermediate-acting Barbiturates
Definition
Time of onset: 30 minutes
Duration of action: 5 to 6 hours
Term
Long-acting Barbiturates
Definition
Time of onset: 1 hour
Duration of action: 8 hours or longer
Term
Ultra-short acting barbiturate
Definition
Sodium Pentathol
Term
the first of the three drugs administered for the death penalty
Definition
Sodium Pentathol
Term
‘truth serum’ vibe about it
Definition
Sodium Pentathol
Term
The first modern antianxiety agent
Definition
Meprobamate
Term
Overprescribed; quickly became widely misused and abused
Definition
Methaqualone (“ludes” or “sopors”)
Term
One of the few drugs that moved in schedule
Definition
Methaqualone (“ludes” or “sopors”)
1973: Put on Schedule II
1985: Put on Schedule I
Term
the first commercially marketed benzodiazepine
Definition
1960: Introduction of chlordiazepoxide (Librium)
Term
Reduces anxiety without inducing sleep
Definition
Benzodiazepines
Term
Overdose rare and usually only when combined with other depressants like alcohol
Definition
Benzodiazepines
Term
Psychological dependence more likely with drugs that have a
Definition
rapid onset of effects
Term
Physical dependence more likely with drugs that have a
Definition
short duration of action
Term
1990s’ version of a “Mickey Finn”
Definition
Rohypnol
Term
Illegal in the United States: schedule 4 drug with schedule 1 penalties
Definition
Rohypnol
Term
Produces profound intoxication when mixed with alcohol
Definition
Rohypnol
If pill is dropped into a drink it changes the color of the drink as a warning
Term
Bond with brain receptors
Enhance the normally inhibitory effects of GABA
Definition
Benzodiazepines and barbiturates
Term
Selectively target the GABA-A receptor
Definition
Nonbenzodiazepine hypnotics
Term
Seem to work better as sleeping pills than as antianxiety drugs
Definition
Nonbenzodiazepine hypnotics
Term
Four benzodiazepines that are among the top 100 most commonly prescribed medications in the United States
Definition
(Xanax, Ativan, Klonopin, Valium)
Term
Concerns about use as sleeping agents
Definition
Hypnotics may induce tolerance, dependence, rebound insomnia, and “hangover” effects
Term
Falling Asleep Without Pills
Definition
Have a regular sleep schedule
When you go to bed, turn out the lights and relax
Exercise regularly but not late in the evening
Prepare a comfortable sleep environment in terms of temperature and noise
Eat a light snack before bed
Avoid tobacco use
If you don’t fall asleep within 30 minutes, get up and do something relaxing before trying to fall asleep again
Do not nap during the day
Avoid chronic use of sleeping pills
Term
Two types of typical depressant abusers
Definition
Older adults using prescription drug who develop tolerance and increase their dosage

Younger people who obtain drugs to get high; may take high doses and/or mix with alcohol
Term
Products that can be abused by inhalation
Definition
include gasoline, glue, paint, lighter fluid, spray cans, nail polish, correction fluid
Term
Four Categories of Inhalants
Definition
Volatile solvents
Aerosols, Propellants, Gases
Anesthetics
Nitrites
Term
Examples of Volatile solvents
Definition
Paint, paint thinner and remover, nail polish remover, correction fluid, glues, cements
Term
Examples of Aerosols, Propellants, Gases
Definition
Spray paint, hair spray, lighters, whipped cream
Term
Examples of Anesthetics
Definition
Current and former medical anesthetics
Term
Examples of Nitrites
Definition
“Locker room,” “Rush,” “poppers”
Term
Nitrous oxide (“laughing gas”) was first used in the early
Definition
1800s
Term
Relaxes blood vessels which increases blood flow, but also lowers blood pressure
Definition
Inhalants: Nitrites
Term
Abuse tends to occur as localized fads
Definition
Inhalants: Volatile Solvents
Term
Most abusers are very young
Definition
Inhalants: Volatile Solvents
Term
Nitrous oxide (“laughing gas”) was first used in the early
Definition
1800s
Term
Relaxes blood vessels which increases blood flow, but also lowers blood pressure
Definition
Inhalants: Nitrites
Term
Abuse tends to occur as localized fads
Definition
Inhalants: Volatile Solvents
Term
Most abusers are very young
Definition
Inhalants: Volatile Solvents
Term
Naturally-occurring chemical found in the brain and body that is considered a date rape drug
Definition
Gamma Hydroxybutyric Acid
Term
Date rape drug that is colorless, odorless, and tasteless
Definition
Gamma Hydroxybutyric Acid
Term
Bipolar Disorder is a
Definition
mood disorder
Term
characterized by excessive worry, fears, or avoidance
Definition
Anxiety disorders
Term
sometimes associated with panic attacks
Definition
Panic disorder
Term
Most don’t leave their home- idea of leaving causes anxiety
Definition
Panic Disorder
Term
thing or event causes excessive worry or fear
Definition
Specific phobia
Term
Debilitated by fear- thinks perfectly rational to be afraid
Definition
Specific phobia
Term
Types of Anxiety Disorders
Definition
Panic disorder
Specific phobia
Social phobia
Obsessive-compulsive disorder
Posttraumatic stress disorder
Generalized anxiety disorder
Term
cannot be comfortable in crowds
Definition
Social phobia
Term
Obsessive thoughts lead to compulsive behaviors
Definition
Obsessive-compulsive disorder
Term
If rituals were not completed something bad would happen
Definition
Obsessive-compulsive disorder
Term
Constant anxiety without singular cause or reason
Definition
Generalized anxiety disorder
Term
agitation and on edge constantly
Definition
Posttraumatic stress disorder
Term
Hyper Arousal
Definition
agitation and on edge constantly
Term
serious mental disorder involving loss of contact with reality
Definition
Psychosis
Term
Delusions and false beliefs
Definition
Schizophrenia
Term
Schizophrenia is a _____ condition
Definition
chronic
Term
Type of psychosis
Definition
Schizophrenia
Term
Schizophrenia typically Characterized by
Definition
Hallucinations
Disorganized speech and behavior
Lack of emotional response
Causes significant interference with social and/or occupational functioning
Can be harmful to self or others
Lack of pleasure in everyday life
Lack of social cues
Term
Greater connection between moms and sons
Definition
Schizophrenia
Term
Schizophrenia diagnosis typically happens between
Definition
late teenage and early twenties
Term
Mood disorders are characterized by
Definition
depressed or manic symptoms
Term
TYpes of mood disorders
Definition
Major depression
Manic episodes
Bipolar disorder
Term
Overwhelming sadness, worthlessness, helplessness
Definition
Major depression
Term
For depression to be considered major is must last for at lease
Definition
6 months
Term
Opposite of depressive episodes
Definition
Manic Episodes
Term
Bipolar disorder tends to
Definition
alternate between manic and depressive episodes
Term
Hypomania
Definition
Bipolar disorder with smaller swing of changes
Term
In the early twentieth century, many psychotic patients were suffering from
Definition
syphilitic infection of the nervous system
Term
Narcosis therapy is
Definition
inducing sleep
Term
Narcosis therapy was used to treat
Definition
mental disorders
Term
Early ways to 'treat' mental disorders
Definition
Insulin-shock therapy
Narcosis therapy
Electroconvulsive therapy
sedatives
Term
Insulin-shock therapy
Definition
Lower insulin to put patients into a stupor
Term
Electroconvulsive therapy believed that
Definition
to cause brain to have a seizure then brain would rewire itself
Term
Called tranquilizers, neuroleptics, or antipsychotics
Definition
Phenothiazines
Term
Phenothiazines (antipychotics)
Definition
Drugs attempted to treat mental illness (psychotic symptoms) without sedation
Term
Treatment with phenothiazines (antipychotics) found to be more effective than
Definition
a placebo
Term
Two groups of antipsychotics
Definition
Conventional or Typical (introduced before mid-1990s)
Atypical (introduced in the past 10-15 years)
Term
difference between two groups of antipsychotics
Definition
only difference is when they came out
Term
Conventional or Typical antipsychotics introduced
Definition
before mid-1990s
Term
Atypical antipsychotics introduced
Definition
in the past 10-15 years
Term
side effects of typical antipsychotics
Definition
Rigidity and muscle spasms
Tremors and restlessness
Long term use- uncontrollable muscle movements
Side effects related to physical movement
Term
side effects of atypical antipsychotics
Definition
Significant weight gain
Drowsiness and dizziness
Term
Antipsychotics produce ________, indicating a link to dopamine receptors
Definition
pseudoparkinsonism
Term
Time delay in drug effects indicates that
Definition
the mechanism of action is probably more complex
Term
Atypical antipsychotics block both
Definition
D2 dopamine and 5HT2A serotonin receptors
Term
Atypical antipsychotics produce ____ pseudoparkinsonism
Definition
less
Term
Safe in that they are not addictive and are difficult to use to commit suicide
Definition
Antipsychotics
Term
Tardive dyskinesia
Definition
uncontrollable muscle movements
Term
Antidepressants: Major Types
Definition
Monoamine oxidase (MAOI) inhibitors
Tricyclic antidepressants
Selective serotonin reuptake inhibitors (SSRIs)
Term
Discovered when a drug for tuberculosis was found to also elevate mood
Definition
Monoamine Oxidase Inhibitors
Term
Believed to work by increasing the availability of serotonin, norepinephrine, and dopamine
Definition
Monoamine Oxidase Inhibitors
Term
Monoamine Oxidase Inhibitors replaced by
Definition
Selective Serotonin Reuptake Inhibitors
Term
Discovered when researchers were working to create a better phenothiazine antipsychotic and found a drug that improved mood
Definition
Tricyclic Antidepressants
Term
Believed to work by reducing the uptake (and thereby increasing the availability) of norepinephrine, dopamine, and serotonin
Definition
Tricyclic Antidepressants
Term
may work by reducing the uptake (and thereby increasing the availability) of serotonin
Definition
Selective Serotonin Reuptake Inhibitors
Term
Safer than tricyclic antidepressants, less likely to lead to overdose deaths
Definition
Selective Serotonin Reuptake Inhibitors
Term
Strong warning from FDA about an increased risk of suicidal tendencies in children and adolescents
Definition
Selective Serotonin Reuptake Inhibitors
Term
No significant difference between actually taking the medication and taking a placebo
Definition
Selective Serotonin Reuptake Inhibitors
Term
Appear to work by increasing the availability of norepinephrine or serotonin
Definition
Antidepressants
Term
Antidepressants have a lag time of about
Definition
2 weeks
Term
Most effective treatment for relieving severe depression
Definition
Electroconvulsive Therapy
Term
Consequences of Drug Treatment for Mental Illness
Definition
Changes for psychiatrists
Civil rights issues relating to hospitalization
From hospital to jail or the street
Term
first psychoactive substance to become demonized in American culture
Definition
alcohol
Term
Saw alcohol as causing problems within the home
Definition
Women’s Christian Temperance Union
Term
States began passing prohibition laws in
Definition
1851
Term
Volstead Act banned alcohol
Definition
18th Amendment
Term
21st Amendment
Definition
Repealed Prohibition (18th Amendment)
Term
the last dry state became wet in 1966
Definition
Mississippi
Term
If the state chose not to increase drinking age up to 21, then the federal government
Definition
didn't fund the building of their highway system
Term
Half of all alcohol consumed in the united states is consumed by
Definition
about 10 percent of the drinkers
Term
Average consumption among drinkers is about
Definition
3 drinks per day, but most drink far less
Term
Standard drink has about ___ ounces of pure alcohol
Definition
0.5
Term
What is one drink?
Definition
12 ounces of beer
5 ounces of wine
1 ounce of 100 proof spirits
1.5 ounces of 80 proof spirits
Term
Behavioral Effects of alcohol
Definition
Sexual behavior
Blackouts
Crime and violence
Term
En bloc Blackout
Definition
memories gone forever
Term
Fragmentary Blackout
Definition
some memories can come back with some reminders
Term
alcohol use is statistically related to
Definition
violence
Term
Physiological Effects of alcohol
Definition
Peripheral circulation
Fluid balance
Hormonal effects
Term
Peripheral circulation
Definition
Dilation of peripheral blood vessels means that drinkers lose body heat but feel warm
Term
Alcohol has a diuretic effect that can
Definition
lower blood pressure in some people
Term
High risk drinking
Definition
5 drinks in a row for a man on a single occ.
4 drinks in a row for a woman on a single occ.
Term
Blackout
Definition
still functioning and moving around and talking
Term
Pass out
Definition
unconscious
Term
Vomiting reflex suppressed at BACs above
Definition
0.20 percent
Term
The only way to avoid a hangover!
Definition
Moderate drinking
Term
Body processes out ____ drink an hour
Definition
1
Term
Fetal Alcohol Spectrum Disorder
Definition
is a series of mental and physical birth defects that can include mental retardation, growth deficiencies, central nervous system dysfunction, craniofacial abnormalities and behavioral maladjustment's.
Term
the #1 cause of preventable mental retardation in the Western world
Definition
Fetal Alcohol Spectrum Disorder
Term
Physical evidence of Fetal Alcohol Spectrum Disorder
Definition
skin folds at corners of eyes
short nose
low nasal bridge
indistinct philtrum
small head circumference
small eye opening
small midface
thin upper lip
Term
Incidence of FAS in America is ____ cases per 1,000 live births
Definition
1.9
Term
Drinking during pregnancy increases risk of
Definition
spontaneous abortion
Term
_______ is medically more severe and more deadly than opioid withdrawal
Definition
Alcohol abstinence syndrome
Term
Stages of Alcohol abstinence syndrome
Definition
Stage 1: tremors, rapid heartbeat, hypertension, heavy sweating, loss of appetite, insomnia
Stage 2: hallucinations (auditory, visual, and/or tactile)
Stage 3: delusions, disorientation, delirium
Stage 4: seizures
Term
Alcoholics Anonymous view alcohol dependence as a
Definition
disease
Term
only treatment for alcohol dependence is
Definition
abstinence from alcohol
Term
APA includes alcohol as a
Definition
psychoactive substances
Term
Alcohol abuse
Definition
a maladaptive pattern indicated by continued use despite knowledge of having persistent problems caused by alcohol
Term
Alcohol dependence
Definition
involves more serious psychosocial characteristics and includes the physiological factors of tolerance and withdrawal among the possible symptoms
Term
Most widely used psychoactive drug
Definition
Caffeine
Term
Belongs to a class of chemicals known as xanthines
Definition
Caffeine
Term
Caffeinated products
Definition
coffee, tea, chocolate
Term
Coffee originated in
Definition
Ethiopia
Term
Cappuccino
Definition
espresso mixed with milk and steamed milk foam
Term
Latte
Definition
espresso with steamed milk
Term
Turkish
Definition
(thicker); similar to black coffee, grounds heated in pot and grounds settle to the bottom of cup
Term
Annual per capita tea consumption
Definition
4.5 pounds in the United Kingdom
1/2 pound in the United States
Term
Preparation: tea leaves are
Definition
Dried
Rolled to crush the cells in the leaves
Placed in a cool, damp place for fermentation (oxidation)
Term
Black tea
Definition
fully oxidized leaves
Term
Green tea
Definition
nonoxidized leaves
Term
Oolong tea
Definition
is greenish-brown and consists of partially oxidized leaves
Term
Iced tea accounts for __ percent of all tea consumed in the U.S.
Definition
Term
Herbal teas contain a mix of
Definition
plant leaves and flowers but no actual tea
Term
Tea contains a very small amount of
Definition
theophylline
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