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Details

URI
Lecture 4 and 5
31
Pharmacology
Professional
02/21/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
What are signs and symptoms of otitis media?
Definition
- Signs - Bulging, immobile tympanic membrane
- Symptoms - Fever, ear pain, Irritability, ear tugging
**More common in kids due to flat eustacian tube
Term
What is the difference between effusion and AOM?
Definition
- Effusion - no S/S of infection. Does not require tx
- AOM- bulging membrane w/ limited mobility. Inflammation
Term
What causes otitis media?
Definition
S. pneumoniae!
**others: H. influenzae and Moraxella catarrhalis
Term
When should Abx be used in otitis media?
Definition
- < 6 months - always use antibiotics
- 6 months - 2 years - Antibiotics if certain, or if severe
- 2+ - Antibiotics only if severe, if not observation
Term
What non-Abx tx can be used for otitis media?
Definition
- Tylenol and NSAIDs
- Auralgan
- Ear tubes
Term
What is the drug of choice in otitis media?
Definition
- Amoxicillin - 80 to 90mg/kg/day divided in q12h
**2nd line = Augmentin, 6.4 mg/kg
Term
What are alternative treatments for Otitis media?
Definition
- Type 1 PCN allergy - Azith and Biaxin
- PCN rxn - 2nd or 3rd gen cephalosporin - cefuroxime, cefprozil, cefpodoxime, cefdinir
Term
What is acute sinusitis?
Definition
Infection of the sinuses or nasal mucosa which usually viral in origin and self limiting
Term
What are the sx of Sinusitis?
Definition
- Rhinorrhea - may be thick and colored
- Nasal congestion
- Facial pain
**Bacterial causes are S. pneumoniae, H. influenzae, M. catarrhalis
Term
When should sinusitis be treated?
Definition
Sx over 7 days
**Amoxicillin 500 mg TID x10 days
** Augmentin for treatment failure
Term
What is pharyngitis?
Definition
Strep Throat - contagious, in young children in certain seasons. Most commonly viral but also caused by S. pyogenes
Term
What are the symptoms of Strep throat?
Definition
Sore throat, difficulty swallowing, fever, HA, Scarlatiniform rash
**Do not see rhinorrea, cough, conjunctivitis
**Diagnosis by S/S + Rapid strep or throat culture
Term
What are complications from strep throat?
Definition
- Acute rheumatic fever - leads to valve dysfunction
- Poststrep glomerulonephritis
- Reactive arthritis
Term
How is strep throat treated?
Definition
Penicillin - excellent coverage of strep pyogenes. Can use injection for kids, otherwise 500 mg BID-TID x10
Term
What is acute bronchitis?
Definition
A LRI that has NO alveolar involvement - cough and congestion > 5 days to weeks.
**Usually viral
Term
When is acute bronchitis treated?
Definition
- In fever/respiratory sx for 4-6 days or in elderly/immunosuppressed patients
** Macrolides (Z-pack), FQNs (Avelox or Levofloxacin), Zanamivir/Oseltamivir
Term
What is chronic bronchitis?
Definition
A LRI - smoker's cough, most days of the week for 3+ months per year for 2 years.
**An advanced stage of right sided HF
Term
What most commonly causes chronic bronchitis?
Definition
- Most common: H. influenzae, S. pneumniae, M. catarrhalis
- Advanced (FEV < 40): E. coli, Klebsiella, Enterobacter, P. aerug
Term
When is chronic bronchitis treated?
Definition
Antibiotic use is controversial - treat COPD exacerbation. Avoid broad spectrum
- Amox 500 TID
- FQN po daily
- Z pack
- Doxy 100 BID
Term
What is the most deadly type of infection in the US?
Definition
Pneumonia - inhalation, aspiration, bloodstream
**Fever, chills, SoB, a productive cough and chest pain
Term
What leads to a Pneumonia diagnosis?
Definition
- Chest Xray
- RR > 20, HR > 90
- Dull to percussion, Egophony
- Crackles
- Incr WBC, culture, hypoxemia
Term
What cultures test for pneumonia?
Definition
- Sputum - least helpful. PMNs = infection
- Aspirate/BAL - from LRT
Term
What causes CAP?
Definition
- Typical: S. pneumoniae, H. influenzae, M. catarrhalis
- Atypical: Mycoplasma pnemoniae, Legionella, Chlamydia pneumoniae
Term
How is CAP treated?
Definition
- No previous Abx in last 3 months - Macrolide (Azith 500 QD, Clarith 500 BID) or Tetra
- Comorbidities, alcohol use, immunosuppressed, OR use of antibiotics w/n last 3 months - FQN (Levaquin 750 or Avelox) or Beta lactam + Macrolide (Augmentin + Azith)
**DO NOT USE CIPRO!!!!
Term
What covers atypical pathogens in CAP?
Definition
Azithromycin + Ceftriaxone
Term
What vaccinations should be received by a CAP patient?
Definition
- Pneumovax - Over 65, high risk, smokers
- influenza
Term
What are different types of nosocomial pneumonia?
Definition
- HCAP - Admission from long term care or nursing home, dialysis, in hospital >2 days in past 90
- HAP - acquired after 48 hours in hospital
- VAP - after intubation
Term
What is the treatment regimen for nosocomial pneumonia?
Definition
- Beta lactam - Cefepime, Ceftazidime. Imipenem/Meropenem/Doripenem, Zosyn, Ticarcillin/Clavulanate, Aztreonam (in PCN allergy)
- AG OR FQN - Amikacin, Gent/Tobra. Levo or cipro only
- MRSA drug - Vanco or Linezolid
**Cubicin does not target lungs. Avelox does not work.
Term
What is the length of dosing for nosocomial pneumonia?
Definition
- 7-8 days
- 14 days for pseudomonas
Term
Who is at risk for aspiration pneumonia?
Definition
- Altered mental status, difficulty swallowing, seizures, alcoholics, periodontal disease
** Oral flora: Peptostrep, Fusobacteria, Bacteroides, Peptococcus
** Other: S. aureus, S. pneumo, gram(-) rods
Term
How is aspiration pneumonia treated?
Definition
Typical HAP tx + anaerobic coverage:
Clinda, metronidazole
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