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UPSOM 2007 B&B Week 4
Stroke, Headaches, Language, Memory, Delirium and Dementia, Tourette, Cell Basis of Learning, Postnatal Neurobiology
7
Medical
Graduate
03/01/2007

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Cards

Term
Types of Memory: definition and related anatomical structures
1. Declarative (2)
2. Procedural (3)
3. Working
Definition
Declarative
1. Semantic: general knowledge
2. Episodic: Time and place details
*Both in the extended Hippocampal system

Procedural
1. Motor/skills: basal ganglia, motor cortices, cerebellum
2. Conditioned reflexes: cerebellum
3. Emotional memory: amygdala

Working Memory: The brain's "RAM"
Prefrontal cortices
Term
Declarative Memory Processing Pathway:
A)Function B)Anatomy C) Type of Amnesia

1) 1' Sensory and Association Cortices

The Limbic System
2) Hippocampus and VM Temporal Lobe
3) Diencephalon
4) Basal Forebrain
5) ??Amygdala??
Definition
1) 1' Sensory and Association Cortices
-1' sensory cortices--> unimodal association areas--> multimodal association areas (TPA and PFA) --> limbic system

Now the Limbic System:

2) Hippocampus and VM Temporal lobe cortices
-Input: sensory association areas
-Integrate senses for perception, recognition, new declarative memory formation
-VMT lobe amnesia-->anterograde and recent memory amnesia, but older memories intact; intellect, personality, and non declarative memory is intact

3) Diencephalon
-Input from above
-Medial thalamic structures
-Diencephalic amnesia: anterograde and retrograde amnesia, temporal disorientation, personality changes. Non-declarative memory intact

4) Basal Forebrain
-Medial Septal Nucleus, Nucleus Basalis of Meynert, et al.
-MSN: "memory"
-NSBM: attention
-Damage, commonly from ACA aneurysm: difficulty recalling and connecting different pieces of information leading to frequent confabulation.

??Amygdala???
-Attaching emotion to memory; modulates memory consolidation and retrieval via cortisol and epinephrine.
-Rare lesion leads to Emotional/Social Agnosia
Term
Stroke
Anterior Circulation
ACA and MCA
1)Watersheds
2)Effect of Infarct
Definition
ACA
1) Midline frontal and parietal lobes
2) Contralateral LE parapesis.
(In ACA's arising from a single trunk, occlusion there leads to bilateral LE parapesis)

MCA
1)Lateral frontal, parietal, temporal, and insular lobes, and some occipital lobe
2)
-Contralateral hemiparesis, face+arm>leg (frontal lobe)
-Aphasia (Broca and Wernicke's/ Dominant Hemisphere)
-Neglect (Non dominant hemisphere)
-Contralateral hemifield/quadrant defect (Optic radiations)
-Deviation of Gaze (FEF's)
-Cortical sensory loss (parietal lobe)
Term
Posterior Circulation Occlusion Symptoms

PICA
BA
PICA
AICA
SCA
Definition
PICA/VA:
1) Lateral Medulla, inferior cerebellum
2)Wallenburg/Lateral Medullary

AICA
1) Dorsal Brainstem, Lateral Pons
SCA
1) Superior Cerebellum, some midbrain
BA 2+2) Crossed facial/body sensorimotor deficits, oculomotor and or ataxia

PCA:
1)medial Occipital Lobe/Visual Cortex, inferior temporal lobe
2) Contralateral hemianopsia (visual field loss)
Term
3 Types of ischemic strokes
1) Carbioembolic stroke
2) Large Vessel atherothromboembolism
3) Small vessel/lacunar
Definition
1) Multiple embolic events; associated with heart conditions.
2) From stenosis; reccurent similiar events in the same vascular territory
3) Associated with diabetes and hypertension. Depends upon clinical syndrome w/o any alternative etiology.

a) pure motor hemiparesis
b) pure sensory stroke
c) clumsy hand/dysarthria syndrome
d) ataxic hemiparesis
Term
Types of Left hemisphere Aphasias and their symptoms

NonFluent
Broca's
Global

Fluent
Wernickes
Conduction
Definition
Broca: knows they are having trouble
-Poor Fluency: effortul,aggrammatic
-Good Comprehension: intact, but agrammatic
-Poor Repetition
-Poor Naming: mildy impaired

Wernicke's: Doesn't understand they are having trouble
-Fluent speech, but empty and circumlocutory
-Poor comprehension: use substitutions
-Impaired repetition
-Poor naming

Conduction
-Fluent
-Intact Comprehension
-Impaired repetition
-Good naming

Global
-Bad at it all
Term
Dementia
1)Causes
2)Criteria
4)Treatment

Delirium
1)Causes
2)Criteria
4)Treatment
Definition
1) Alzheimers, Lewy Body Dis, vascular
2) INSIDIOUS, NO CHANGES IN CONCIOUSNESS Memory loss, other cognitive disturbances, functional impairment, cognitive decline from higher level
4) PROGRESSIVE, treat comorbidities, caregiver support

Delirium
1) Any drugs or condition that causes cerebral insufficiency
2) DISTURBED CONCIOUSNESS AND ATTENTION, change in cognition/perception, ABRUPT ONSET, BRIEF fluctuating course, evidence of causal factor: drugs or medical condition
4. REVERSIBLE
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