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Details

Upper GI
Drugs regarding the upper GI tract
27
Pharmacology
Undergraduate 3
04/14/2010

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Cards

Term
H2 Receptor Blockers 'Rantidine' Mechanism of Action
Definition
Blocks H2 receptors in parietal cells of stomach- increase gastric pH
Term
H2 Receptor Blockers 'Rantidine' Indications
Definition
Peptic ulcer; GERD; Hypersecretory conditions; Prevent upper GI bleed, heartburn, and acid indigestion (OTC)
Term
H2 Receptor Blockers 'Rantidine' Contraindications
Definition
Hypersensitivity
Term
H2 Receptor Blockers 'Rantidine' Serious Adverse Effects
Definition
Neutropenia; Agranulocytosis; Thrombocytopenia; Autoimmune hemolytic or aplastic anemia RARE
Term
H2 Receptor Blockers 'Rantidine' Common Adverse Effects
Definition
None
Term
H2 Receptor Blockers 'Rantidine' Preadministration Assessment
Definition
Assess diet and smoking habits (Highly acidic and spiced food may increase symptoms, smoking aggrevates)
Term
H2 Receptor Blockers 'Rantidine' Monitoring
Definition
Resolution of symptoms; S/S of blood dyscrasias (sore throat, fever, bruising, fatigue)
Term
H2 Receptor Blockers 'Rantidine' Key Patient Education
Definition
Take daily even if no symptoms; Do not substitute OTC for prescription
Term
H2 Receptor Blockers 'Rantidine' Notes
Definition
Interacts with numerous drugs; Give at least 2 hours apart from antacids
Term
Proton Pump Inhibitors 'Omeprazole' Mechanism of Action
Definition
Suppressess the hydrogen-potassium ATPase enzyme system- increased gastric pH, decreased pepsin activity
Term
Proton Pump Inhibitors 'Omeprazole' Indications
Definition
Peptic ulcers; GERD; Erosive esophagitis; Chronic hypersecretory conditions
Term
Proton Pump Inhibitors 'Omeprazole' Contraindications
Definition
Hypersensitivity
Term
Proton Pump Inhibitors 'Omeprazole' Serious Adverse Effects
Definition
May increase risk of gastric cancer with longg-term use; Decrease symptoms of gastric cancer
Term
Proton Pump Inhibitors 'Omeprazole' Common Adverse Effects
Definition
Headache and Diarrhea
Term
Proton Pump Inhibitors 'Omeprazole' Preadministration assessment
Definition
Assess diet and smoking habits (highly acidic and spiced food may increase symptoms, smoking aggravates)
Term
Proton Pump Inhibitors 'Omeprazole' Monitoring
Definition
Resolution of symptoms
Term
Proton Pump Inhibitors 'Omeprazole' Key Patient Education
Definition
Take daily even if no symptoms; Take 1 hour before meals; Do not crush or chew tablet
Term
Proton Pump Inhibitors 'Omeprazole' Notes
Definition
Antisecretory effect lasts 24 hours; May interfere with drugs needing specific pH; Interact with drugs metabolized through cytochrome P-450 pathway (inc levels)
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Mechanism of Action
Definition
Increased gastric pH
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Indications
Definition
Upset stomach, heart burn, symptoms associated with GERD
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Contraindications
Definition
Chronic renal failure (toxicity with repeated doses)
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Serious Adverse Effects
Definition
Electrolyte imbalance
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Common Adverse Effects
Definition
Constipation (AH) Diarrhea (MH)- combination usually negates but either can occur.
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Preadministration assessment
Definition
Symptoms
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Monitoring
Definition
Relief of symptoms
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Key Patient Education
Definition
Take 2 hours after other drugs to minimize drug interactions; not effective alone for treating peptic ulcer disease
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Notes
Definition
Interacts with drugs requiring specific pH- administer 2 hours after other drugs; May bind with other drugs making them ineffective; Increases urinary pH which could affect elimination of other drugs
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