Term
H2 Receptor Blockers 'Rantidine' Mechanism of Action |
|
Definition
Blocks H2 receptors in parietal cells of stomach- increase gastric pH |
|
|
Term
H2 Receptor Blockers 'Rantidine' Indications |
|
Definition
Peptic ulcer; GERD; Hypersecretory conditions; Prevent upper GI bleed, heartburn, and acid indigestion (OTC) |
|
|
Term
H2 Receptor Blockers 'Rantidine' Contraindications |
|
Definition
|
|
Term
H2 Receptor Blockers 'Rantidine' Serious Adverse Effects |
|
Definition
Neutropenia; Agranulocytosis; Thrombocytopenia; Autoimmune hemolytic or aplastic anemia RARE |
|
|
Term
H2 Receptor Blockers 'Rantidine' Common Adverse Effects |
|
Definition
|
|
Term
H2 Receptor Blockers 'Rantidine' Preadministration Assessment |
|
Definition
Assess diet and smoking habits (Highly acidic and spiced food may increase symptoms, smoking aggrevates) |
|
|
Term
H2 Receptor Blockers 'Rantidine' Monitoring |
|
Definition
Resolution of symptoms; S/S of blood dyscrasias (sore throat, fever, bruising, fatigue) |
|
|
Term
H2 Receptor Blockers 'Rantidine' Key Patient Education |
|
Definition
Take daily even if no symptoms; Do not substitute OTC for prescription |
|
|
Term
H2 Receptor Blockers 'Rantidine' Notes |
|
Definition
Interacts with numerous drugs; Give at least 2 hours apart from antacids |
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Mechanism of Action |
|
Definition
Suppressess the hydrogen-potassium ATPase enzyme system- increased gastric pH, decreased pepsin activity |
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Indications |
|
Definition
Peptic ulcers; GERD; Erosive esophagitis; Chronic hypersecretory conditions |
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Contraindications |
|
Definition
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Serious Adverse Effects |
|
Definition
May increase risk of gastric cancer with longg-term use; Decrease symptoms of gastric cancer |
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Common Adverse Effects |
|
Definition
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Preadministration assessment |
|
Definition
Assess diet and smoking habits (highly acidic and spiced food may increase symptoms, smoking aggravates) |
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Monitoring |
|
Definition
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Key Patient Education |
|
Definition
Take daily even if no symptoms; Take 1 hour before meals; Do not crush or chew tablet |
|
|
Term
Proton Pump Inhibitors 'Omeprazole' Notes |
|
Definition
Antisecretory effect lasts 24 hours; May interfere with drugs needing specific pH; Interact with drugs metabolized through cytochrome P-450 pathway (inc levels) |
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Mechanism of Action |
|
Definition
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Indications |
|
Definition
Upset stomach, heart burn, symptoms associated with GERD |
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Contraindications |
|
Definition
Chronic renal failure (toxicity with repeated doses) |
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Serious Adverse Effects |
|
Definition
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Common Adverse Effects |
|
Definition
Constipation (AH) Diarrhea (MH)- combination usually negates but either can occur. |
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Preadministration assessment |
|
Definition
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Monitoring |
|
Definition
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Key Patient Education |
|
Definition
Take 2 hours after other drugs to minimize drug interactions; not effective alone for treating peptic ulcer disease |
|
|
Term
Antacids Aluminum Hydroxide and Magnesium Hydroxide Notes |
|
Definition
Interacts with drugs requiring specific pH- administer 2 hours after other drugs; May bind with other drugs making them ineffective; Increases urinary pH which could affect elimination of other drugs |
|
|