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Unit 8 - Sensory Drugs
Test 2
86
Nursing
Undergraduate 3
03/14/2014

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Term
What are congenital cataracts? What is the cause associated with it? Symptoms? Treatment?
Definition
Clouding of the lens at birth.

NO CAUSE ASSOCIATED but:
Chromosomal conditions and intrauterine infection (Rubella) have high incidences.

Surgery to remove them, artificial lens placement, patch, and treat UNDERLYING disorder.
Term
What is anotia?
Definition
Absence of the auricle
Term
What is microtia?
Definition
Underdeveloped small auricle
Term
What is atresia?
Definition
Lacks external ear canal
Term
What gender is associated with congenital ear defects?
Definition
Males. Associated with other conditions affecting the head.
Term
How do congenital ear defects manifest themselves?
Definition
Can be uni or bilateral
Term
What is congenital hearing loss associated with?
Definition
Maternal rubella and syphilis.
Term
When do age related eye changes begin?
Definition
30
Term
What are age related eye changes?
Definition
-Decreased tear production
-Cornea less sensitive (unable to detect injury)
-Pupils decrease 1/3 size @ age 60
-Pupils react more slowly to light
-Lens becomes yellowed, less flexible, cloudy
-Eye sinks back into the skull
-Eye muscles weaken - limiting visual field
-Presbyoipa - difficulty focusing
Term
What is conjunctivitis? Symptoms? What are the 2 types and their differences?
Definition
Infection/inflammation of the conjunctiva (lining of eyelid)

Symptoms: blurry vision, photophobia

-Viral: watery, mucus exodate -> contagious
-Bacterial: yellow-green exudate -> contagious
Term
What are causes of conjunctivitis and the risk factors for getting it? What are teachings?
Definition
Causes - virus, bacteria, allergens, chemicals, trauma

R.F. - Contact lenses, contaminated makeup, opthalmic medications.

Teachings: hand washing, limit contact, eye hygiene, d/c contaminated products
Term
How do you treat conjunctivitis?
Definition
May resolve on it's own. If not: opthalmic/oral antibiotics, antihistamines, corticosteriod agents, warm compress to sooth.
Term
What is infant conjunctivitis?
Definition
Infant gets it from Mom's STI. Treat it with opthalmic antibiotics shortly after birth.
Term
What is keratitis? What causes it?
Definition
Inflammation of the cornea triggered by infection or trauma. HSV-1 can be self-transmitted from the mouth to cause ulcerated keratitis.
Term
What are the symptoms of keratitis? How is it treated?
Definition
Severe pan, photophobia, visual disturbances. Opthalmic/Oral antibiotics and corticosteriods.
Term
What are 2 topical anesthetics used in the eyes? What do you need to do afterwards?
Definition
Proparacaine HCL & Tertracaine HCL.

Wear a patch until affects are gone.
Term
What are some antibacterial antiinfectives used in the eye?
Definition
-Chloramphenicol - For treatment of severe infections
-Ciproflaxin - Bacterial conjunctivitis
-Erythromycin - Most commonly used
-Gentamicin Sulfate - External eye infections. (Preg C)
-Levofloxacin - Conjunctivitis & coreal ulcers
-Norfloxacin - Conjunctivitis
-Silver Nitrate - Opthalmia neonatorum
-Sulfacetamide - Not effective w/ purulent drainage
-Tobramycin - External ocular infections
-Tetracycline HCL - ALternative to silver nitrate
-Triple antibiotic opthalmic ointment - Combo dosage
Term
What is an ocular anti fungal?
Definition
Natamycin - can cause stinging or burning
Term
What are the 3 ocular antivirals?
Definition
Ioxuridine - To treat herpes simplex keratitis
Trifluridine - Herpectic opthalmic infections
Vidarabine monohydrate - Herpes simplex keratitis
Term
What are some non steroidal ocular antiinflammatories?
Definition
Diclofenac sodium - postop inflammation/photophobia
Flurbiprofen sodium - Decrease corneal edema, miosis
Ketorolac tormethamine - Itching w/ allergies
Suprofen - Prevent intraoperative miosis
Term
What are some steroidal ocular antiinflammatories?
Definition
-Dexmethasone - Inflammation of conjunctiva, cornea, lids.
-Medrysone - Allergic conditions
-Prednisone acetate - Uveitis, allergic cond., burns, inflamm.
-Predisolone sodium - Prevent/decrease tissue response to inflammatory process
-Tobramycin - Fungal/mycobacterial/viral infections
Term
What are clinical manifestations of direct physical trauma or chemical burns?
Definition
Pain, edema, blurred vision, diplopia, dry eyes, photophobia, floaters, pupil dilation, pupils unresponsive to light
Term
How do you treat direct physical trauma or chemical burns to the eyes?
Definition
saline flush, avoid rubbing, leave embedded object, sterile dressing, eye patch, surgically repair
Term
What is glaucoma?
Definition
SECOND LEADING CAUSE OF BLINDNESS

Increased IOP that leads to damage to the optic nerve by decreased blood flow to the optic nerve by:
-blocked outflow of aqueous humor
-increased production of aqueous humor
Term
What is open angle glaucoma?
Definition
MOST COMMON!

IOP increases gradually over time.

Usually painless, insidious, bilateral changes in vision such as tunnel vision, blurred vision, halos, decreased color discrimination.
Term
How do beta blockers treat open angle glaucoma?
Definition
Reduce aqueous humor production (BB)
Term
How do alpha agonists treat OA glaucoma?
Definition
Reduction in production and an increase in drainage of a. humor
Term
How do carbonic anhydrase inhibitors treat OA glaucoma?
Definition
Reduces aqueous humor production (CAI)
Term
How do prostaglandin-like compounds treat OA glaucoma?
Definition
Increase a. humor outflow (P)
Term
How do miotics/cholinergic agents treat OA glaucoma?
Definition
Increase a. humor outflow. (M/C)
Term
How do epinephrine compounds treat OA glaucoma?
Definition
Increase a. humor outflow (E)
Term
How do alpha-2 adrenergic agonists treat OA glaucoma?
Definition
Protect the optic nerve
Term
Are oral carbonic anhydrase drugs used to treat OA glaucoma used alone or in combo. with other drugs?
Definition
Combination
Term
How do n-methyl-d-aspartate receptors treat OA gluacoma?
Definition
Protect the optic nerve
Term
What non pharmacological treatments are used for OAG?
Definition
-Laser surgery to open a. humor flow
-Filtering surgery (remove small part of trabecular meshwork)
-Drainage implants
Term
What is the drug action of cholinergic/anticholinesterace miotics?
Definition
Direct acting, Lower IOP, increase blood flow to retina and decrease retinal damage.
Term
What is miosis?
Definition
Pupil constriction
Term
Who should NOT use pilocarpine?
Definition
Patients w/ retinal detachment, adhesions between eyes/lens, acute ocular inflammation, must avoid systemic absorption with coronary artery disease, epilepsy, asthma.
Term
What is ocusert?
Definition
7 day dose of pilocarpine
Term
What are the side effects of pilocarpine?
Definition
Blurred vision, eye pain, headache, eye irritation, brow ache, stinging/burning, nausea, vomiting, diarrhea, increased salivation/perspiration, muscle tremors, contact allergy, conjunctival irritation w/ occusert.
Term
What are the adverse rxn of pilocarpine?
Definition
Dyspnea, TACHYCARDIA, HYPERTENSION, RETINAL DETACHMENT, BRONCHOSPASM.
Term
What are the first line treatment of OA glaucoma?
Definition
Beta-Adrenergic Blockers.
Term
What are the side effects with beta-adrenergic blockers?
Definition
Bradycardia, hypotension, bronchospasm
Term
Who shouldn't use beta-adrenergic blockers?
Definition
Asthmatic patients, those already taking oral beta blockers for their heart.
Term
What is the benefit of prostaglandin analogues?
Definition
Work the same as beta blockers but without the side effects.
Term
What are osmotics used to treat?
Definition
ACUTE closed angle glaucoma. Decreases A. humor volume rapidly which also reduces IOP.
Term
What are the side effects of osmotics? What should you check?
Definition
Headache, nausea, vomiting, diarrhea, electrolyte imbalances. Intake and output levels, electrolyte levels, daily weight.
Term
What is mannitol? SE?
Definition
Osmotic drug. Pulmonary edema/congestion, anuria (no pee), and dehydration.
Term
What is closed angle glaucoma?
Definition
MEDICAL EMERGENCY!

There is a sudden block of aqueous humor outflow.

Caused by trauma, sudden pupil dilation, prolonged pupil dilation, emotional stress.

USUALLY HAPPENS UNILATERALLY.
Term
What are the clinical manifestations of CAG?
Definition
Sudden onset:
-Sever eye pain
-HA,
-Nausea
-Vomiting
-Nonreactive pupil
-Haziness of cornea, visual changes (halos)
Term
How is C.A.G. treated?
Definition
Iridotomy - surgical laser procedure to open a new channel in the iris.

Meds -> Anticholinergic mydriatics + cycloplegics
Term
Why do they use anticholinergic mydriatics/cycloplegics before C.A.G. surgery?
Definition
Dilate pupils and paralyze eye muscles
Term
What is congenital glaucoma?
Definition
Present @ birth. Abnormal development of outflow channels of the eye. Follows X-linked, recessive hereditary pattern.
Term
What are the clinical manifestations of congenital glaucoma?
Definition
Excessive lacrimation, photophobia, corneal edema, grey-white appearance of cornea, enlarged eye globe, vision deficit.
Term
How is congenital glaucoma treated?
Definition
surgery to open the AH outflow. Laser, filtering, drainage implants.
Term
What is secondary glaucoma?
Definition
IT's the result of corticosteroid use, eye diseases, arteriosclerosis and diabetes mellitus.
Term
How is secondary glaucoma treated?
Definition
Chronic disease management, eliminated underlying causes, glaucoma meds and surgical treatments
Term
What are diagnostic tests used to diagnose glaucoma?
Definition
-H&P
-Complete opthalmic exam
-Tonometry (measure of IOP)
-Visual acuity testing
-Visual field measurement
-At risk persons should be screened annually
Term
What is a cataract?
Definition
Clouding of the lens uni or bilaterally.

Cloudy/fuzzy/foggy/filmy vision
Color intensity loss
Diplopia
Impaired night vision/halos/photosensitivity
Frquent changes in eye glasses or contact rx
Term
What are the risk factors for cataracts?
Definition
-Family history
-advances age
-smoking
-uv light exposure
-diabetes mellitus
-corticosteriods
-eye injury
Term
What is macular degeneration?
Definition
Deterioration of the macular area of the retina caused by impaired blood supply to the macula.
Term
What are the risk factors for mac. degeneration?
Definition
advanced age, family, tendency, females, caucasian, smoking, high fat diet, obesity.
Term
Clinical manifestations of macular degeneration?
Definition
Affects the ability to read, drive, watch television, and do routine daily tasks (ADL’s)
Term
What is dry macular degernation?
Definition
Blood vessels under the macula become thin and brittle. Causes blurred vision and dim spots in the central vision. Progesses gradually. Most common. NO TREATMENT
Term
What is wet macular degeneration?
Definition
Brittle vessels break down and new fragile vessels grow under the macula and they leak. Less common. Sudden onset with rapid loss of vision. Distortion of straight lines, dark sports in central vision, sudden loss of central vision.
NO CURE. Laser surgery, photodynamic therapy, antiangiogenesis (slows formation of new blood vessels)
Term
What medications treat wet macular degenerations?
Definition
Pegaptanib - injectible eye agent used to stabilize vision loss slightly
Ranibizumab - injectible eye agent used to stop vision loss or improve vision in the early stages of wet age-related macular degeneration 65+
Term
What is retinal detachment?
Definition
MEDICAL EMERGENCY
Acute condition in which the retina separates from supporting structures, vitreous humor leaks through a retinal tear and accumulates under retina which causes it to peel away from the choroid. Expands overtime and leads to ischemic retina and vision loss.
Term
What are the clinical manifestations of retinal detachment?
Definition
Flashes of light in the peripheral vision, blurred vision, floaters, darkening vision (curtain)

REQUIRES EMERGENCY SURGERY
Term
What are age related changes in the ear
Definition
Structures thicken
Presbycusis - hearing loss
Impacted cerumen
Sensioneural loss - damage to inner ear, auditory nerve, brain
Conductive hearing loss - transmission problem from outer to inner ear
Tinnitus
Term
What is otitis media?
Definition
Infection in the middle ear that is common to young children with narrow, straight, and short eustachian tubes. Fluid does not drain properly, sets stage for bacteria. Also adenoid enlargement causes fluid to compress tube
Term
How does otitis media begin?
Definition
Begins with URT infection, may lead to ruptured tympanic membrane, scar tissue, conductive hearing loss
Term
What are the risk factors for otitis media?
Definition
Daycares
Supine feedings for infants
Smoke exposure
History of allergic rhinitis
Term
What are the clinical manifestations of otitis media?
Definition
Ear pain, crying, irritability
Rubbing, pulling at the ear
Mild hearing deficits
Sleep disturbances
Red bulging tympanic membrane
Fever, malaise, and chills
Purulent or clear exudate (ruptured tympanic)
N/V/HA
Term
How is otitis media treated?
Definition
Eradicate infection-oral and otologic antibiotics
Decrease fluid- oral decongestant & antihistamine
Manage pain- anagesics
Control fever-antipyretic
Drainage tubes/removal of adenoids
Term
What is usually used to treat OM? What if there is an allergy?
Definition
Amoxicillin 40-45mg/kg PO twice daily, 5-10days
PCN allergy then:
Azithromycin or clarithromycin
Cephalosporins if not severe allergy to PCN
Cefaclor (Ceclor)
SE-overgrowth or non-susceptible organism, hypersensitivity
CI- hypersensitivity
Term
What is otitis externa? Who is at risk?
Definition
Swimmer's ear. Infection/inflammation to the outer ear. usually bacterial in origin but may be fungal. Those who swim in contaminated water, scratchers of ears, foreign objects in ears.
Term
What are the clinical manifestations of OE? Treatments?
Definition
Clinical manifestations
Ear pain worsens with auricle movement
Purulent exudate
Itiching
Fullness in the ear
Hearing deficits
Diagnostics: H&P, otologic exam, exudate C&S
Treatment: local otologic antibiotic, antifungal, corticosteroids, analgesics, saline lavage
Prevention strategies: drying ears after swimming, avoid foreign bodies, treat pools properly
Term
What drugs are used to treat OE?
Definition
Swimmers ear- Ear-Dry, Debrox gtts up to 4 days
See Table 49.9
Fluoroquinolones
Oral Cipro (adults) or Keflex (children) if extended to pinna
Antihistamine-decongestants
Reduces nasal and ear congestion
Reduces edema and promotes drainage of middle ear
SE-drowsiness, dry mucosa membranes
Term
What is a ceruminolytic?
Definition
Loosens and removes cerumen from the ear canal
Irrigate with ½ hydrogen peroxide sol. And ½ water or Debrox
1-2 gtts of olive oil or mineral oil softens wax
Term
What are traumatic disorders of the ear?
Definition
Direct physical trauma
Excessively loud noises
Can result in hearing loss
Clinical manifestations: bloody or clear exudate, tinnitus, dizziness, ear pain, deficits, N/V/Edema
Treatment: remove object, surgery, limit loud sounds to allow healing
Term
What is otosclerosis?
Definition
Abnormal bone growth in the middle ear
Prevents ear structures from vibrating
Unknown cause, hereditary, pregnancy may trigger
Progressive hearing loss
Nerve loss can occur in conjunction with conductive loss
Most common in women and Caucasians
Term
How is otosclerosis treated?
Definition
Hearing aids
Surgery to remove the stapes and replace with prosthetic
Laser Surgery to create an opening in the stapes, prosthetic device may be placed
Term
What is meniere's disease?
Definition
Disorder of the inner ear from endolymph swelling
Swelling interferes with hair receptors in the cochlea and vestibule
Cause is unknown
Associated with head injuries, otitis media, syphilis
Risk factors: allergic rhinitis, alcohol, stress, fatigue, medications (ASA), respiratory infection
Term
What are the clinical manifestations of meineire's disease?
Definition
Clinical manifestation:
Waves of acute episodes lasting months with brief periods of relief
Triggered by barometric pressure or risk factors
Intermittent vertigo
Tinnitus,
Unilateral hearing loss, sensation of fullness
Repeated episodes lead to hearing loss
Term
What are the treatments for meniere's disease?
Definition
Treatment: no cure, Relieve pressure and symptoms
Antihistamine agents
Benzodiazepines
Anticholinergic agents
Diuretics
Antiemetics
Avoid triggers
Gentamicin, corticosteriods (reduce swelling) injections
Surgical removal of endo lymph or inner ear, vestibular nerve resection
Hearing aids, PT to improve balance
Term
Notes on Meniere's Diseases:
Definition
Disruption of the endolymph (fluid in inner ear assist with hearing) due to jerky movements (like spinning around or driving over bumps while riding in a car) can cause motion sickness.[2] A condition where the volume of the endolymph is greatly enlarged is called endolymphatic hydrops and has been linked to Ménière's disease
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