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Unit 3: From Embryos to Systems
Reproductive systems, embryonic development, hormone regulation of plant development, organization and function of vascular plants, homeostasis, gas exchange and circulation, the immune system
212
Biology
Undergraduate 1
05/06/2012

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Term
Somatic cell
Definition
Any cell of a living organism besides reproductive
Term
Gametogenesis makes a germ cell into a gamete, a ______________, goal being diploid to haploid.
Definition
Cell with half the number of chromosomes of a somatic cell (eggs and sperm)
Term
The keys to reproduction are...
Definition
hormonal negative and positive feedback loops
Term
Diploid means there are _ copies of each chromosome per cell.
Definition
2
Term
Haploid means there are _ copies of each chromosome per cell.
Definition
1
Term
Meiosis produces...
Definition
haploid germ cells
Term
In the seminiferous tubule, cell proliferation occurs rapidly; meiosis occurs twice; spermatocytes are produced and then differentiated into sperm. In short, 1 diploid spermatogonium (stem cell) produces...
Definition
4 haploid sperm
Term
Sertoli cells
Definition
control the development of spermatids in the seminiferous tubules.
Term
Seminiferous tubules are surrounded by connective tissue, blood vessels and _____ cells, which along with sertoli cells, INFLUENCE THE DEVELOPMENT OF GERM CELL TO SPERM CELL.
Definition
leydig
Term
Leydig cells secrete ___ which influences ____
Definition
testosterone, rate of proliferation
Term
Both Sertoli and Leydig cells regulate sperm cell development through...
Definition
hormone secretion
Term
The hypothalamus of the brain secretes _____ which stimulates the pituitary to secrete Follicle-Stimulating Hormone and Luteinizing Hormone (FSH and LH).
Definition
Gonadotropin-releasing hormone (GnRH)
Term
FSH stimulates...
Definition
Sertoli cells to nourish developing sperm
Term
LH stimulates...
Definition
Leydig cells to secrete testosterone
Term
TESTOSTERONE and INHIBIN are two ___________ which send signals back to the pituitary and hypothalamus when sperm production becomes too high.
Definition
Negative feedback loops
Term
Through mitosis and two meiosis events,one diploid primary oocyte produces how many secondary haploid oocytes?
Definition
One
Term
In the female, when the egg is released, the ruptured follicle develops into the...
Definition
corpus luteum
Term
What are the two branches of the immune system?
Definition
Innate vs. Adaptive
Term
Where are all red blood cells, white blood cells and platelets made?
Definition
Bone marrow
Term
What is passive immunity?
Definition
Antibodies gotten from someone else (eg breastfeeding)
Term
What acts the same way in all individuals, requires no previous exposure to a pathogen, is seen in many types of animals, is available early in infection, and is necessary for induction of adaptive immunity?
Definition
Innate immunity
Term
What is specific to given pathogens, occurs within the lifetime of an individual, is found only in vertebrates, takes time to mount, and increases effectiveness of innate immunity?
Definition
Adaptive immunity
Term
What is the source of all immune cells?
Definition
Bone marrow
Term
From where does immune cell development occur?
Definition
A pluripotent stem cell
Term
What is the site of immune cell development and activation?
Definition
Lymphoid system (central lymphoid, peripheral lymphoid + mucosal immune system)
Term
What facilitates the interaction of immune cells with pathogens?
Definition
Movement of lymph
Term
What are five innate defenses?
Definition
Barriers, phagocytosis/inflammation, Fever, Complement, Natural Killer cells
Term
What do NK cells target?
Definition
Cells lacking MHC class I
Term
What is complement and what does it do?
Definition
Floating inactive proteins in blood which become activated when they bind to pathogen surfaces; promote pathogen clearance and inflammation by causing immune responses
Term
What is the cause of a fever?
Definition
Microbial pyrogens induce fever through cytokine effects on hypothalamus (Adjusting "set point")
Term
What are three types of barriers?
Definition
Physical, chemical, microbiological
Term
What are the two types of primary phagocytic cells?
Definition
Neutrophils and macrophages
Term
What do PRRs (Toll-like receptor family) recognize?
Definition
PAMP- Pathogen-Associated Molecular Proteins
Term
When a phagocyte's PRR recognizes a PAMP and binds to a pathogen, what are the four Cs which could result?
Definition
Cytokines, (chemokines), costimulatory activity, complement
Term
What does inflammation do?
Definition
Brings immune cells to site of infection, facilitates pathogen clearance. Vasodilation=more blood=redness, heat; Vasopermeability=more fluid=swelling; Increased nerve signalling=pain
Term
In the immune system, what are the two initial options a pluripotent stem cell could become?
Definition
Myeloid stem cell; lymphoid stem cell
Term
What do lymphoid stem cells become?
Definition
T-lymphocyte (Thymus); NK lymphocyte; B lymphocyte/plasma cell
Term
What do myeloid stem cells become?
Definition
Erythrocyte,Megakaryocyte (clotting), monocyte/macrophage
Term
What are neutrophils, basophils, eosinophils, and mast cells considered?
Definition
Granlocytes
Term
What are cytokines?
Definition
Soluble protein molecules secreted by immune cells; messengers of the immune system
Term
What are chemokines?
Definition
A subset of cytokines that signal location
Term
Almost all healthy cells express...
Definition
MHC Class I
Term
What is MHC Class I?
Definition
The flagpole that presents small peptides from intracellular proteins to the immune system
Term
What are alpha and beta INTERFERON cytokines and what do they do?
Definition
Caused by virally infected cells; stimulate NK cells
Term
Adaptive acquired responses are due to actions of what two types of cells?
Definition
B- and T-
Term
What are B-cells responsible for?
Definition
Antibody production
Term
What are T-cells responsible for?
Definition
Cell mediated response
Term
What are the two types of T cells?
Definition
Cytotoxic T-cells and Helper T-cells
Term
What do cytotoxic T cells do?
Definition
Kill infected cells
Term
What do helper T cells do?
Definition
Increase activity of other cells of the immune system (macrophages, B cells, CTLs)
Term
Adaptive acquired responses due to B and T cells help potentiate the function of other immune system cells via cytokines and antibodies. Name 5.
Definition
NK cells, Macrophages/neutrophils, Eosinophils, Basophils, Mast cells
Term
What is an antigen?
Definition
A protein whose "epitope" is recognized as foreign- "non-self", by immunoglobulin (Ig) of B cells or TCR (T-cell receptor) on T-cells
Term
How does an antibody bind directly to an antigen?
Definition
Two identical binding sites; light chain, heavy chain; Variable vs constant regions; disulfide bridge; non-covalent bonds
Term
Immunization prevents infection by inducing...
Definition
an adaptive immune response.
Term
What are the two types of helper T cells?
Definition
Helper Th1 cells and Helper Th2
Term
What do Helper Th1 cells do?
Definition
Stimulate macrophages and neutrophils
Term
What do Helper Th2 cells do?
Definition
Stimulate B cells to become plasma cells that secrete antibody
Term
How do cytotoxic T-cells kill infected cells via apoptosis?
Definition
Perforins: make hole in membrane so granzymes can enter
Granzymes: initiate programmed cell death pathway
Term
Antigen-presenting cells (APC) display peptides from pathogen in MHC molecules. What is displayed in MHC Class I and what in MHC Class II?
Definition
Peptides from cytoplasmic pathogens in Class I; peptides from endocytosed pathogens in Class II
Term
In the absence of infection, what is loaded in MHC?
Definition
self peptides
Term
What leads to proliferation and activation of B and T lymphocytes with receptors that bind to antigen?
Definition
Clonal selection
Term
How are a diverse number if Lg/TCR receptors created?
Definition
Somatic recombination
Term
Name 3 antigen presenting cells.
Definition
Macrophages, Dendritic cells, B cells
Term
T cells are stimulated by dendritic cells and macrophages through what two signals?
Definition
TCR binding to MHC containing non-self Ag; Costimulatory activity (expressed only by APC in response to activation by PAMP:PRR pathway)
Term
B cells are stimulated by T cells through what three interacting signals?
Definition
Binding of Ab to Ag; TCR binding to MHC containing Ag; Costimulatory activity
Term
What are the two organs of the central lymphoid system?
Definition
Bone marrow, thymus
Term
What do activated T cells do?
Definition
1) serve as CTL or 2) produce helper cytokines
Term
What's so great about antigen specificity?
Definition
Biologics (mab drugs), research, diagnostics
Term
An antigen can have several epitopes and different _____ can bind to each.
Definition
Antibodies
Term
Allergies and asthma are...
Definition
immune responses to innocuous substances
Term
Autoimmune diseases are...
Definition
immune responses to self proteins
Term
What is the acrosome?
Definition
Front portion of sperm head which enables it to break down the surface of the egg
Term
Where is a sperm's nucleus located?
Definition
Head
Term
Where are the mitochondria that power the sperm?
Definition
Midpiece
Term
Sperm matures in what direction in the sem. tubules?
Definition
From outside in
Term
The blastocyst is totipotent, meaning...
Definition
Capable of giving rise to both embryo and extra-embryonic tissue
Term
How are labor contractions initiated?
Definition
Estradiol stimulates oxytocin stimulates contractions & prostaglandins in placenta which also stimulate contractions
Term
What coordinates the timing of the thickening of the endometrium lining with the maturation of the oocyte?
Definition
Secretion of estrogen by the ovaries
Term
What triggers the follicle to rupture and release the oocyte?
Definition
Peak in estradiol triggers a surge in primary LH
Term
Secretion of progesterone and estrogen in the follicle/corpus luteum is a signal for what?
Definition
FSH and LH levels to stay down
Term
If implantation occurs, how does the CL know to stick around?
Definition
Endometrium lining secretes HCG (Human Chorionic Gonadotropin)
Term
What does a lack of progesterone and estrogen stimulate?
Definition
Sloughing off of endometrium lining; FSH and LH levels to increase to produce another oocyte
Term
What are three components of the ectoderm?
Definition
Epidermis, CNS, neural crest
Term
What are five components of the mesoderm?
Definition
Dorsal (notochord), bone, kidney, red blood cells, facial muscle
Term
What are three components of the endoderm?
Definition
Digestive tube, respiratory system, pharynx/thyroid
Term
What are the three germ layers from what should be inside to what should be outside?
Definition
Endoderm, mesoderm, ectoderm
Term
What are the 11 body systems?
Definition
Respiratory, Nervous, Circulatory, Urinary, Reproductive, Endocrine, Digestive, Skeletal, Lymph/immune, Integumentary, Muscular (RN CURED SLIM)
Term
What is a homeotic mutation?
Definition
One structure is replaced by another
Term
The embryonic period is most susceptible to exogenous agents, or _____
Definition
tetragens
Term
What are HOX genes?
Definition
Encode different regions along the A-P axis
Term
What is the back region called?
Definition
Dorsal (knuckles)
Term
What is the front region called?
Definition
Ventral (palm)
Term
What is the lower region called?
Definition
Posterior (pinky)
Term
What is the upper region called?
Definition
Anterior (thumb)
Term
What is the region closest to your body (core) called, as in limbs?
Definition
Proximal (shoulder)
Term
What is the region farthest from your body (as in limbs), called?
Definition
Distal (fingertips)
Term
What is the essence of differential gene expression and the Gene Regulatory Network (GRN) as it relates to embryogenesis?
Definition
TxFs cause different cells to express different genes at different times, which controls cell fates and thus development.
Term
HOX genes are colinear, meaning...
Definition
Their position in 3' to 5' sequence matches that of A-P
Term
What is the order of stages in embryonic development (7)?
Definition
Fertilization, Cleavage (Blastula), Gastrulation, Neurulation, Organogenesis, Gametogenesis
Term
What says when the MBT will occur?
Definition
Nucleocytoplasmic ratio
Term
What is the MBT?
Definition
Mid-blastula transition; when zygotic genome becomes activated (before this, mRNAs from mom stored in the oocyte cytoplasm have been used for cell division)
Term
What is the starting point of gastrulation & only self-determined tissue in early gastrula?
Definition
Dorsal Blastopore Lip, "organizer"
Term
What does the DBL do?
Definition
Secretes inducer molecules (morphogens) in a gradient to regulate cell fate at different concentrations
Term
What is a mitogen?
Definition
Morphogen with a goal of cell proliferation
Term
DBL secretes dorsalizing inducer molecules, such as
Definition
noggin and chordin
Term
Noggin and chordin are antagonized by ____, causing gradient that establishes D-V axis
Definition
BMP
Term
During neurulation, notochord and floor plate secrete what?
Definition
Sonic Hedgehog
Term
During neurulation, epidermis secretes what?
Definition
BMP
Term
What kinds of neurons does BMP induce during neurulation?
Definition
Dorsal (sensory)
Term
What kinds of neurons does SHH induce during neurulation?
Definition
Motor neurons
Term
What does the SHH-BMP gradient during neurulation produce in the middle of the neural tube?
Definition
Interneurons
Term
Lower surface tension tends to envelope...
Definition
higher surface tension
Term
The ZPA (Zone of Polarizing Activity) in the limb bud secrets SHH (co-opted) which has the ability to?
Definition
Specify digits along A-P axis
Term
Secondary induction is...
Definition
formation of neural tube
Term
Primary induction is...
Definition
envelopment of mesoderm
Term
What modulates cell-cell adhesion and thus surface tension?
Definition
Cadherins such as E (epithelial) cadherin, N (CNS, mesoderm) Cadherin, and Protocadherin (separates notochord from mesoderm)
Term
What are the three types of plant tissue?
Definition
Dermal, vascular, ground
Term
Dermal (epidermis) plant tissue
Definition
Outer layer, single cell thick, protection, some specialized cells
Term
Vascular tissue of plants
Definition
xylem and phloem for transport
Term
Ground tissue of plants
Definition
"filter", parenchyma, general metabolism, support & structure
Term
Where are photoreceptors located?
Definition
Tip of coleoptile
Term
Wtf is a coleoptile?
Definition
Sheath protecting young shoot
Term
How do tropisms (gravi, photo) work?
Definition
Cause different rate of growth on one side due to accumulation of auxins
Term
What are examples of photomorphogenesis (plant processes resulting from light)?
Definition
Greening, germination, shoot elongation, reproduction, shade avoidance, stomatal opening
Term
Root
Definition
anchor, storage
Term
Shoot
Definition
Photosynthesis, reproduction, storage
Term
What causes axis formation in plants?
Definition
Asymmetry
Term
What is the order of stages of plant development (7 stages)? Zeigler taught our goat hot tamales matter.
Definition
Zygote; Two Cells; Octant; "Heart" embryo; "Torpedo" embryo; Mature plant
Term
Annual
Definition
one year
Term
Perennial
Definition
long-lived
Term
Biennial
Definition
Two year (flowers 2nd year)
Term
Meristems
Definition
Plant embryonic initial stem cells, divide repeatedly
Term
Meristem divides into...
Definition
1 derivative daughter cell (can become apical (height) or lateral (girth)); and 1 meristem copy
Term
Tropisms...
Definition
Plant growth regulation: environmental signals and genetic program must be coordinated through body responses (cell division, expansion, differentiation, and death)
Term
What are three types of plant receptors?
Definition
Photoreceptors (specific wavelengths), mechanical sensors (gravity, touch), hormone receptors (chemical signalling)
Term
What is a photoreceptor?
Definition
Chromophore attached to protein
Term
What senses blue light?
Definition
Phototropin, zeaxanthin (caretenoid) - opening/closing stomata, cryptochrome (BL + UV) - help set circadian rhythms
Term
What senses red and far red light?
Definition
Phytochrome, acts as molecular light switch (changes conformation and locattion when perceives light) and stimulates gene expression
Term
What is the key to hormone signalling in plants?
Definition
RATIOS
Term
Where is auxin made?
Definition
apical meristem
Term
Where does auxin go?
Definition
Polar transport to base of plant (1-way)
Term
What does auxin do?
Definition
Stimulates plant cell growth
Term
What is the acid growth hypothesis?
Definition
Auxin enters cell as acid or base; becomes base inside cytoplasm and makes cell wall more acidic by stimulating proton pumps; stimulates expansins; which loosen cell wall; turgor pressure then causes elongation of cells
Term
In photo and gravi tropism respectively, where does auxin accumulate?
Definition
On dark, bottom sides
Term
What is ethylene an' what does it do?
Definition
It's a gas which promotes senescence (aging, dying), fruit ripening, is used commercially to synchronize ripening; inhibits auxin
Term
What controls leaf abscission?
Definition
Balance of auxin and ethylene (auxin forms abscission layer while ethylene degrades it)
Term
Petiole
Definition
connects leaf to stem
Term
How do guard cells function?
Definition
Surround stomata and assist in opening/closing and passage of CO2, water, etc. through hole.
Term
Which side of the leaf are the stomata on?
Definition
Bottom
Term
In what direction is the movement of water and nutrients?
Definition
"source to sink"
sugar goes from leaf to apical growth zone; water goes from ground to leaves
Term
What is bulk flow?
Definition
Movement of fluid from high pressure areas to low pressure driven by evaporation
Term
What is "transpiration-cohesion tension"?
Definition
Evaporation through stomata dries mesophyll wall, which pulls water from inner cells. The resulting tension sucks water (cohesive) up xylem from soil
Term
What opens the stomata?
Definition
Blue light receptor; low CO2 levels; circadian rhythms
Term
What closes the stomata?
Definition
Water stress (Drying), abscisic acid, heat, high CO2
Term
Symplast
Definition
through cells (plasmodesmata)
Term
Apoplast
Definition
Between/around cells
Term
Casparian strip
Definition
Turns symplast transport to apoplast
Term
About 90% of a plant's water loss occurs..
Definition
out of stomata
Term
Xylem
Definition
evaporation from leaves drives bulk flow of water to occur through tracheids and dead vessel elements
Term
Phloem
Definition
Active transport of sugars at each end drives bulk flow of organic nutrients (mostly sugars) long seive tube members
Term
Integumentary system
Definition
protect against injury and infections; help maintain temperature
Term
Skeletal system (bones, tendons, ligaments)
Definition
structure and organ protection; marrow provides stem cells for blood and immune cells
Term
Nervous system- 3 sections
Definition
CNS - brain and spinal cord; PNS- carries nerve impulses to muscle and glands; ANS- Autonomic - regulates involuntary actions (smooth muscle)
Term
Endocrine system
Definition
Glandular system, secretes hormones directly into bloodstream
Term
Circulatory system
Definition
eliminates CO2 in lungs, provides waterway transport for hormones and nutrients; delivers nutrients and O2, collects wastes
Term
Respiratory system
Definition
Allows environment for CO2 to from blood to be exchanged for O2 from air (for aerobic respiration - > oxidative phosphorylation)
Term
Immune system
Definition
Lymphatic system (generates and circulates white blood cells) and immune cells
Term
Digestive system
Definition
Breakdown food and extract nutrients into macromolecules
Term
Urinary system
Definition
eliminates waste
Term
Reproductive system
Definition
Sperm from male fertilizes female ovum in fallopian tubes
Term
How do systems communicate with each other?
Definition
Nervous system (quick) and endocrine system (slow)
Term
Two options for thermoregulation?
Definition
Conform to external environment or regulate internal
Term
Homeostasis
Definition
Regulation of internal parameters through feedback responses; body tries to maintain "set point" of a given variable; fluctuations generate stimulus which is sensed by receptor which triggers response
Term
Human body parameters for temp, pH, sugar, respectively
Definition
Temp, 37C, 98.6F, Ph 7.4; 0.9 mg/mL glucose
Term
Endotherm
Definition
warmed by metabolism; can withstand large fluctuations in either warm or cold temperatures
Term
Ectotherm
Definition
utilize behavior to regulate temperature
Term
An _____ can maintain its body temperature by regulating metabolism rates, whereas an _______ cannot.
Definition
Endotherm, ectotherm
Term
Behaviors of ectotherms: Radiation
Definition
Emission of EM waves absorbed by animal (sun)
Term
Behaviors of ectotherms: Conduction
Definition
transfer of heat from object
Term
Behaviors of ectotherms: Evaporation
Definition
Removal of heat as liquid becomes gas (Sweat)
Term
Behaviors of ectotherms: Convection
Definition
Movement of water or air across a surface
Term
How does integumentary system help regulate temperature?
Definition
Hair (insulation), muscle (shivering), blood vessels (dilation cools while constriction warms), oil glands (insulation by repelling water), sweat glands
Term
Small, thin animals do not need a heart because _____, and they have what kind of system?
Definition
They can exchange materials directly At surface, they have a gastrovascular system (satisfies both eating and gas exhange)
Term
All circulatory systems contain what three components?
Definition
Muscular pump, fluid (blood or hemolymph), set of tubes or conduits
Term
Two types of circulatory systems?
Definition
Open, closed
Term
Open circulatory system
Definition
Hemolymph- blood and hemolymph all mixed together
Term
Closed circulatory system
Definition
Blood confined to vessels, distinct from interstitial fluid, capillary beds=site of exchange
Term
Capillaries->venules->veins->heart->arteries->arterioles->capillaries
Definition
know that shit
Term
Cardiac cycle
Definition
rhymthic cycle of heart contraction and relaxation
Term
Systole
Definition
Contraction (pumping) phase
Term
Diastole
Definition
Relaxation (filling) phase
Term
Stroke volume
Definition
Amt of blood pumped in one contraction (about 70 mL)
Term
Heart rate
Definition
beats per minute
Term
Cardiac output
Definition
Vol of blood pumped into systematic circulation per minute (dependent on HR and SV)
Term
Gas diffusion happens in ______ surrounding _____
Definition
capillary beds; alveoli
Term
What drives diffusion of O2 and CO2?
Definition
Partial pressure differences
Term
When one subunit (iron + heme) binds or unloads O2, what happens to the other subunit affinities?
Definition
Do the same-- PEER PRESHA
Term
Hemoglobin changes conformation at lower pHs to more readily...
Definition
unload 02 (in areas of higher CO2 that need it for instance muscles during excercise.)
Term
Things going different ways (such as arteries and veins, or water and blood in aquatic species)...
Definition
Transfer heat to each uvva
Term
What controls exchange of blood with interstitial fluid in capillary beds?
Definition
Blood pressure in relation to osmotic pressure
Term
What is countercurrent exchange?
Definition
In aquatic species, water and blood pass in opposite directions; water always has a higher PP02
Term
What regulates blood flow to different regions?
Definition
Vasoconstriction and vasodilation and/or regulation of precapillary sphincters
Term
Sympathetic (Norinepinephrin)
Definition
Increase HR
Term
Parasympathetic (acetylcholine)
Definition
Decrease HR
Term
Nodes
Definition
SA, AV
Term
Artery walls are ___ as thick as veins
Definition
3x; to handle pressure of pumped fluid and maintain structure during relaxation
Term
Veins have what kind of valves...
Definition
unidirectional "flap" valves
Term
Pacemaker
Definition
Specialized cardiomyocytes which conduct electrical impulses to synchronize cardiac contractions
Term
How do capillaries ensure easy exchange of gases b/w RBC and interstitial fluid?
Definition
Close proximity; thin walls; many many to allow same volume through (rate decreases by 500x)
Term
Nitrous oxide does what?
Definition
activates a second messenger cGMP which stimulates smooth muscle relaxation; vasodilation
Term
Endothelin and angiotensin are ligands which activate G-protein coupled receptors which activate...
Definition
Ca++ flux and contraction -> vasoconstriction
Term
What is causing embryo 1's two heads?
Definition
CT1 is upregulating chordin coupled with less BMP produced, chordin antagonizes BMP, ordinarily, too much chordin, gradient gets messed up, development of second dorsal lip, second invagination, causes two-headed embryo
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