Term
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Definition
Any cell of a living organism besides reproductive |
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Term
Gametogenesis makes a germ cell into a gamete, a ______________, goal being diploid to haploid. |
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Definition
Cell with half the number of chromosomes of a somatic cell (eggs and sperm) |
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Term
The keys to reproduction are... |
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Definition
hormonal negative and positive feedback loops |
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Term
Diploid means there are _ copies of each chromosome per cell. |
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Definition
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Term
Haploid means there are _ copies of each chromosome per cell. |
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Definition
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Term
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Definition
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Term
In the seminiferous tubule, cell proliferation occurs rapidly; meiosis occurs twice; spermatocytes are produced and then differentiated into sperm. In short, 1 diploid spermatogonium (stem cell) produces... |
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Definition
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Term
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Definition
control the development of spermatids in the seminiferous tubules. |
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Term
Seminiferous tubules are surrounded by connective tissue, blood vessels and _____ cells, which along with sertoli cells, INFLUENCE THE DEVELOPMENT OF GERM CELL TO SPERM CELL. |
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Definition
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Term
Leydig cells secrete ___ which influences ____ |
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Definition
testosterone, rate of proliferation |
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Term
Both Sertoli and Leydig cells regulate sperm cell development through... |
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Definition
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Term
The hypothalamus of the brain secretes _____ which stimulates the pituitary to secrete Follicle-Stimulating Hormone and Luteinizing Hormone (FSH and LH). |
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Definition
Gonadotropin-releasing hormone (GnRH) |
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Term
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Definition
Sertoli cells to nourish developing sperm |
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Term
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Definition
Leydig cells to secrete testosterone |
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Term
TESTOSTERONE and INHIBIN are two ___________ which send signals back to the pituitary and hypothalamus when sperm production becomes too high. |
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Definition
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Term
Through mitosis and two meiosis events,one diploid primary oocyte produces how many secondary haploid oocytes? |
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Definition
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Term
In the female, when the egg is released, the ruptured follicle develops into the... |
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Definition
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Term
What are the two branches of the immune system? |
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Definition
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Term
Where are all red blood cells, white blood cells and platelets made? |
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Definition
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Term
What is passive immunity? |
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Definition
Antibodies gotten from someone else (eg breastfeeding) |
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Term
What acts the same way in all individuals, requires no previous exposure to a pathogen, is seen in many types of animals, is available early in infection, and is necessary for induction of adaptive immunity? |
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Definition
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Term
What is specific to given pathogens, occurs within the lifetime of an individual, is found only in vertebrates, takes time to mount, and increases effectiveness of innate immunity? |
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Definition
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Term
What is the source of all immune cells? |
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Definition
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Term
From where does immune cell development occur? |
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Definition
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Term
What is the site of immune cell development and activation? |
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Definition
Lymphoid system (central lymphoid, peripheral lymphoid + mucosal immune system) |
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Term
What facilitates the interaction of immune cells with pathogens? |
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Definition
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Term
What are five innate defenses? |
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Definition
Barriers, phagocytosis/inflammation, Fever, Complement, Natural Killer cells |
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Term
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Definition
Cells lacking MHC class I |
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Term
What is complement and what does it do? |
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Definition
Floating inactive proteins in blood which become activated when they bind to pathogen surfaces; promote pathogen clearance and inflammation by causing immune responses |
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Term
What is the cause of a fever? |
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Definition
Microbial pyrogens induce fever through cytokine effects on hypothalamus (Adjusting "set point") |
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Term
What are three types of barriers? |
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Definition
Physical, chemical, microbiological |
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Term
What are the two types of primary phagocytic cells? |
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Definition
Neutrophils and macrophages |
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Term
What do PRRs (Toll-like receptor family) recognize? |
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Definition
PAMP- Pathogen-Associated Molecular Proteins |
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Term
When a phagocyte's PRR recognizes a PAMP and binds to a pathogen, what are the four Cs which could result? |
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Definition
Cytokines, (chemokines), costimulatory activity, complement |
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Term
What does inflammation do? |
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Definition
Brings immune cells to site of infection, facilitates pathogen clearance. Vasodilation=more blood=redness, heat; Vasopermeability=more fluid=swelling; Increased nerve signalling=pain |
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Term
In the immune system, what are the two initial options a pluripotent stem cell could become? |
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Definition
Myeloid stem cell; lymphoid stem cell |
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Term
What do lymphoid stem cells become? |
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Definition
T-lymphocyte (Thymus); NK lymphocyte; B lymphocyte/plasma cell |
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Term
What do myeloid stem cells become? |
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Definition
Erythrocyte,Megakaryocyte (clotting), monocyte/macrophage |
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Term
What are neutrophils, basophils, eosinophils, and mast cells considered? |
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Definition
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Term
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Definition
Soluble protein molecules secreted by immune cells; messengers of the immune system |
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Term
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Definition
A subset of cytokines that signal location |
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Term
Almost all healthy cells express... |
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Definition
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Term
|
Definition
The flagpole that presents small peptides from intracellular proteins to the immune system |
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Term
What are alpha and beta INTERFERON cytokines and what do they do? |
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Definition
Caused by virally infected cells; stimulate NK cells |
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Term
Adaptive acquired responses are due to actions of what two types of cells? |
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Definition
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|
Term
What are B-cells responsible for? |
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Definition
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|
Term
What are T-cells responsible for? |
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Definition
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Term
What are the two types of T cells? |
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Definition
Cytotoxic T-cells and Helper T-cells |
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Term
What do cytotoxic T cells do? |
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Definition
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Term
What do helper T cells do? |
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Definition
Increase activity of other cells of the immune system (macrophages, B cells, CTLs) |
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Term
Adaptive acquired responses due to B and T cells help potentiate the function of other immune system cells via cytokines and antibodies. Name 5. |
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Definition
NK cells, Macrophages/neutrophils, Eosinophils, Basophils, Mast cells |
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Term
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Definition
A protein whose "epitope" is recognized as foreign- "non-self", by immunoglobulin (Ig) of B cells or TCR (T-cell receptor) on T-cells |
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Term
How does an antibody bind directly to an antigen? |
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Definition
Two identical binding sites; light chain, heavy chain; Variable vs constant regions; disulfide bridge; non-covalent bonds |
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Term
Immunization prevents infection by inducing... |
|
Definition
an adaptive immune response. |
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Term
What are the two types of helper T cells? |
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Definition
Helper Th1 cells and Helper Th2 |
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Term
What do Helper Th1 cells do? |
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Definition
Stimulate macrophages and neutrophils |
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Term
What do Helper Th2 cells do? |
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Definition
Stimulate B cells to become plasma cells that secrete antibody |
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Term
How do cytotoxic T-cells kill infected cells via apoptosis? |
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Definition
Perforins: make hole in membrane so granzymes can enter Granzymes: initiate programmed cell death pathway |
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Term
Antigen-presenting cells (APC) display peptides from pathogen in MHC molecules. What is displayed in MHC Class I and what in MHC Class II? |
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Definition
Peptides from cytoplasmic pathogens in Class I; peptides from endocytosed pathogens in Class II |
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Term
In the absence of infection, what is loaded in MHC? |
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Definition
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|
Term
What leads to proliferation and activation of B and T lymphocytes with receptors that bind to antigen? |
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Definition
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|
Term
How are a diverse number if Lg/TCR receptors created? |
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Definition
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|
Term
Name 3 antigen presenting cells. |
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Definition
Macrophages, Dendritic cells, B cells |
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Term
T cells are stimulated by dendritic cells and macrophages through what two signals? |
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Definition
TCR binding to MHC containing non-self Ag; Costimulatory activity (expressed only by APC in response to activation by PAMP:PRR pathway) |
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Term
B cells are stimulated by T cells through what three interacting signals? |
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Definition
Binding of Ab to Ag; TCR binding to MHC containing Ag; Costimulatory activity |
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|
Term
What are the two organs of the central lymphoid system? |
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Definition
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|
Term
What do activated T cells do? |
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Definition
1) serve as CTL or 2) produce helper cytokines |
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Term
What's so great about antigen specificity? |
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Definition
Biologics (mab drugs), research, diagnostics |
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Term
An antigen can have several epitopes and different _____ can bind to each. |
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Definition
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|
Term
Allergies and asthma are... |
|
Definition
immune responses to innocuous substances |
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Term
Autoimmune diseases are... |
|
Definition
immune responses to self proteins |
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Term
|
Definition
Front portion of sperm head which enables it to break down the surface of the egg |
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|
Term
Where is a sperm's nucleus located? |
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Definition
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|
Term
Where are the mitochondria that power the sperm? |
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Definition
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|
Term
Sperm matures in what direction in the sem. tubules? |
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Definition
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|
Term
The blastocyst is totipotent, meaning... |
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Definition
Capable of giving rise to both embryo and extra-embryonic tissue |
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Term
How are labor contractions initiated? |
|
Definition
Estradiol stimulates oxytocin stimulates contractions & prostaglandins in placenta which also stimulate contractions |
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|
Term
What coordinates the timing of the thickening of the endometrium lining with the maturation of the oocyte? |
|
Definition
Secretion of estrogen by the ovaries |
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|
Term
What triggers the follicle to rupture and release the oocyte? |
|
Definition
Peak in estradiol triggers a surge in primary LH |
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|
Term
Secretion of progesterone and estrogen in the follicle/corpus luteum is a signal for what? |
|
Definition
FSH and LH levels to stay down |
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Term
If implantation occurs, how does the CL know to stick around? |
|
Definition
Endometrium lining secretes HCG (Human Chorionic Gonadotropin) |
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|
Term
What does a lack of progesterone and estrogen stimulate? |
|
Definition
Sloughing off of endometrium lining; FSH and LH levels to increase to produce another oocyte |
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|
Term
What are three components of the ectoderm? |
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Definition
Epidermis, CNS, neural crest |
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Term
What are five components of the mesoderm? |
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Definition
Dorsal (notochord), bone, kidney, red blood cells, facial muscle |
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Term
What are three components of the endoderm? |
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Definition
Digestive tube, respiratory system, pharynx/thyroid |
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Term
What are the three germ layers from what should be inside to what should be outside? |
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Definition
Endoderm, mesoderm, ectoderm |
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|
Term
What are the 11 body systems? |
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Definition
Respiratory, Nervous, Circulatory, Urinary, Reproductive, Endocrine, Digestive, Skeletal, Lymph/immune, Integumentary, Muscular (RN CURED SLIM) |
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|
Term
What is a homeotic mutation? |
|
Definition
One structure is replaced by another |
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|
Term
The embryonic period is most susceptible to exogenous agents, or _____ |
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Definition
|
|
Term
|
Definition
Encode different regions along the A-P axis |
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|
Term
What is the back region called? |
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Definition
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|
Term
What is the front region called? |
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Definition
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|
Term
What is the lower region called? |
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Definition
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|
Term
What is the upper region called? |
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Definition
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|
Term
What is the region closest to your body (core) called, as in limbs? |
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Definition
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|
Term
What is the region farthest from your body (as in limbs), called? |
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Definition
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Term
What is the essence of differential gene expression and the Gene Regulatory Network (GRN) as it relates to embryogenesis? |
|
Definition
TxFs cause different cells to express different genes at different times, which controls cell fates and thus development. |
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|
Term
HOX genes are colinear, meaning... |
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Definition
Their position in 3' to 5' sequence matches that of A-P |
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|
Term
What is the order of stages in embryonic development (7)? |
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Definition
Fertilization, Cleavage (Blastula), Gastrulation, Neurulation, Organogenesis, Gametogenesis |
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Term
What says when the MBT will occur? |
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Definition
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Term
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Definition
Mid-blastula transition; when zygotic genome becomes activated (before this, mRNAs from mom stored in the oocyte cytoplasm have been used for cell division) |
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Term
What is the starting point of gastrulation & only self-determined tissue in early gastrula? |
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Definition
Dorsal Blastopore Lip, "organizer" |
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Term
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Definition
Secretes inducer molecules (morphogens) in a gradient to regulate cell fate at different concentrations |
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Term
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Definition
Morphogen with a goal of cell proliferation |
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|
Term
DBL secretes dorsalizing inducer molecules, such as |
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Definition
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|
Term
Noggin and chordin are antagonized by ____, causing gradient that establishes D-V axis |
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Definition
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|
Term
During neurulation, notochord and floor plate secrete what? |
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Definition
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|
Term
During neurulation, epidermis secretes what? |
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Definition
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|
Term
What kinds of neurons does BMP induce during neurulation? |
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Definition
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|
Term
What kinds of neurons does SHH induce during neurulation? |
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Definition
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|
Term
What does the SHH-BMP gradient during neurulation produce in the middle of the neural tube? |
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Definition
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|
Term
Lower surface tension tends to envelope... |
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Definition
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|
Term
The ZPA (Zone of Polarizing Activity) in the limb bud secrets SHH (co-opted) which has the ability to? |
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Definition
Specify digits along A-P axis |
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|
Term
Secondary induction is... |
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Definition
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Term
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Definition
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|
Term
What modulates cell-cell adhesion and thus surface tension? |
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Definition
Cadherins such as E (epithelial) cadherin, N (CNS, mesoderm) Cadherin, and Protocadherin (separates notochord from mesoderm) |
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Term
What are the three types of plant tissue? |
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Definition
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|
Term
Dermal (epidermis) plant tissue |
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Definition
Outer layer, single cell thick, protection, some specialized cells |
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Term
Vascular tissue of plants |
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Definition
xylem and phloem for transport |
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Term
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Definition
"filter", parenchyma, general metabolism, support & structure |
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Term
Where are photoreceptors located? |
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Definition
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|
Term
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Definition
Sheath protecting young shoot |
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|
Term
How do tropisms (gravi, photo) work? |
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Definition
Cause different rate of growth on one side due to accumulation of auxins |
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Term
What are examples of photomorphogenesis (plant processes resulting from light)? |
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Definition
Greening, germination, shoot elongation, reproduction, shade avoidance, stomatal opening |
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Term
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Definition
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Term
|
Definition
Photosynthesis, reproduction, storage |
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|
Term
What causes axis formation in plants? |
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Definition
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Term
What is the order of stages of plant development (7 stages)? Zeigler taught our goat hot tamales matter. |
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Definition
Zygote; Two Cells; Octant; "Heart" embryo; "Torpedo" embryo; Mature plant |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Two year (flowers 2nd year) |
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Term
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Definition
Plant embryonic initial stem cells, divide repeatedly |
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Term
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Definition
1 derivative daughter cell (can become apical (height) or lateral (girth)); and 1 meristem copy |
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Term
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Definition
Plant growth regulation: environmental signals and genetic program must be coordinated through body responses (cell division, expansion, differentiation, and death) |
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Term
What are three types of plant receptors? |
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Definition
Photoreceptors (specific wavelengths), mechanical sensors (gravity, touch), hormone receptors (chemical signalling) |
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Term
|
Definition
Chromophore attached to protein |
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Term
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Definition
Phototropin, zeaxanthin (caretenoid) - opening/closing stomata, cryptochrome (BL + UV) - help set circadian rhythms |
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Term
What senses red and far red light? |
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Definition
Phytochrome, acts as molecular light switch (changes conformation and locattion when perceives light) and stimulates gene expression |
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|
Term
What is the key to hormone signalling in plants? |
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Definition
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Term
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Definition
|
|
Term
|
Definition
Polar transport to base of plant (1-way) |
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Term
|
Definition
Stimulates plant cell growth |
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|
Term
What is the acid growth hypothesis? |
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Definition
Auxin enters cell as acid or base; becomes base inside cytoplasm and makes cell wall more acidic by stimulating proton pumps; stimulates expansins; which loosen cell wall; turgor pressure then causes elongation of cells |
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|
Term
In photo and gravi tropism respectively, where does auxin accumulate? |
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Definition
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|
Term
What is ethylene an' what does it do? |
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Definition
It's a gas which promotes senescence (aging, dying), fruit ripening, is used commercially to synchronize ripening; inhibits auxin |
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|
Term
What controls leaf abscission? |
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Definition
Balance of auxin and ethylene (auxin forms abscission layer while ethylene degrades it) |
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Term
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Definition
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|
Term
How do guard cells function? |
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Definition
Surround stomata and assist in opening/closing and passage of CO2, water, etc. through hole. |
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|
Term
Which side of the leaf are the stomata on? |
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Definition
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|
Term
In what direction is the movement of water and nutrients? |
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Definition
"source to sink" sugar goes from leaf to apical growth zone; water goes from ground to leaves |
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|
Term
|
Definition
Movement of fluid from high pressure areas to low pressure driven by evaporation |
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|
Term
What is "transpiration-cohesion tension"? |
|
Definition
Evaporation through stomata dries mesophyll wall, which pulls water from inner cells. The resulting tension sucks water (cohesive) up xylem from soil |
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Term
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Definition
Blue light receptor; low CO2 levels; circadian rhythms |
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Term
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Definition
Water stress (Drying), abscisic acid, heat, high CO2 |
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Term
|
Definition
through cells (plasmodesmata) |
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Term
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Definition
|
|
Term
|
Definition
Turns symplast transport to apoplast |
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|
Term
About 90% of a plant's water loss occurs.. |
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Definition
|
|
Term
|
Definition
evaporation from leaves drives bulk flow of water to occur through tracheids and dead vessel elements |
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Term
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Definition
Active transport of sugars at each end drives bulk flow of organic nutrients (mostly sugars) long seive tube members |
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Term
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Definition
protect against injury and infections; help maintain temperature |
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Term
Skeletal system (bones, tendons, ligaments) |
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Definition
structure and organ protection; marrow provides stem cells for blood and immune cells |
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Term
Nervous system- 3 sections |
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Definition
CNS - brain and spinal cord; PNS- carries nerve impulses to muscle and glands; ANS- Autonomic - regulates involuntary actions (smooth muscle) |
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Term
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Definition
Glandular system, secretes hormones directly into bloodstream |
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Term
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Definition
eliminates CO2 in lungs, provides waterway transport for hormones and nutrients; delivers nutrients and O2, collects wastes |
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Term
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Definition
Allows environment for CO2 to from blood to be exchanged for O2 from air (for aerobic respiration - > oxidative phosphorylation) |
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Term
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Definition
Lymphatic system (generates and circulates white blood cells) and immune cells |
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Term
|
Definition
Breakdown food and extract nutrients into macromolecules |
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Term
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Definition
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|
Term
|
Definition
Sperm from male fertilizes female ovum in fallopian tubes |
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|
Term
How do systems communicate with each other? |
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Definition
Nervous system (quick) and endocrine system (slow) |
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|
Term
Two options for thermoregulation? |
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Definition
Conform to external environment or regulate internal |
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Term
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Definition
Regulation of internal parameters through feedback responses; body tries to maintain "set point" of a given variable; fluctuations generate stimulus which is sensed by receptor which triggers response |
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|
Term
Human body parameters for temp, pH, sugar, respectively |
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Definition
Temp, 37C, 98.6F, Ph 7.4; 0.9 mg/mL glucose |
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|
Term
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Definition
warmed by metabolism; can withstand large fluctuations in either warm or cold temperatures |
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|
Term
|
Definition
utilize behavior to regulate temperature |
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|
Term
An _____ can maintain its body temperature by regulating metabolism rates, whereas an _______ cannot. |
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Definition
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|
Term
Behaviors of ectotherms: Radiation |
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Definition
Emission of EM waves absorbed by animal (sun) |
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|
Term
Behaviors of ectotherms: Conduction |
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Definition
transfer of heat from object |
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|
Term
Behaviors of ectotherms: Evaporation |
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Definition
Removal of heat as liquid becomes gas (Sweat) |
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|
Term
Behaviors of ectotherms: Convection |
|
Definition
Movement of water or air across a surface |
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|
Term
How does integumentary system help regulate temperature? |
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Definition
Hair (insulation), muscle (shivering), blood vessels (dilation cools while constriction warms), oil glands (insulation by repelling water), sweat glands |
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Term
Small, thin animals do not need a heart because _____, and they have what kind of system? |
|
Definition
They can exchange materials directly At surface, they have a gastrovascular system (satisfies both eating and gas exhange) |
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|
Term
All circulatory systems contain what three components? |
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Definition
Muscular pump, fluid (blood or hemolymph), set of tubes or conduits |
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Term
Two types of circulatory systems? |
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Definition
|
|
Term
|
Definition
Hemolymph- blood and hemolymph all mixed together |
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|
Term
Closed circulatory system |
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Definition
Blood confined to vessels, distinct from interstitial fluid, capillary beds=site of exchange |
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|
Term
Capillaries->venules->veins->heart->arteries->arterioles->capillaries |
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Definition
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|
Term
|
Definition
rhymthic cycle of heart contraction and relaxation |
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Term
|
Definition
Contraction (pumping) phase |
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Term
|
Definition
Relaxation (filling) phase |
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Term
|
Definition
Amt of blood pumped in one contraction (about 70 mL) |
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Term
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Definition
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|
Term
|
Definition
Vol of blood pumped into systematic circulation per minute (dependent on HR and SV) |
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|
Term
Gas diffusion happens in ______ surrounding _____ |
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Definition
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|
Term
What drives diffusion of O2 and CO2? |
|
Definition
Partial pressure differences |
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|
Term
When one subunit (iron + heme) binds or unloads O2, what happens to the other subunit affinities? |
|
Definition
Do the same-- PEER PRESHA |
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|
Term
Hemoglobin changes conformation at lower pHs to more readily... |
|
Definition
unload 02 (in areas of higher CO2 that need it for instance muscles during excercise.) |
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|
Term
Things going different ways (such as arteries and veins, or water and blood in aquatic species)... |
|
Definition
Transfer heat to each uvva |
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|
Term
What controls exchange of blood with interstitial fluid in capillary beds? |
|
Definition
Blood pressure in relation to osmotic pressure |
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|
Term
What is countercurrent exchange? |
|
Definition
In aquatic species, water and blood pass in opposite directions; water always has a higher PP02 |
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|
Term
What regulates blood flow to different regions? |
|
Definition
Vasoconstriction and vasodilation and/or regulation of precapillary sphincters |
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|
Term
Sympathetic (Norinepinephrin) |
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Definition
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|
Term
Parasympathetic (acetylcholine) |
|
Definition
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|
Term
|
Definition
|
|
Term
Artery walls are ___ as thick as veins |
|
Definition
3x; to handle pressure of pumped fluid and maintain structure during relaxation |
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|
Term
Veins have what kind of valves... |
|
Definition
unidirectional "flap" valves |
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|
Term
|
Definition
Specialized cardiomyocytes which conduct electrical impulses to synchronize cardiac contractions |
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|
Term
How do capillaries ensure easy exchange of gases b/w RBC and interstitial fluid? |
|
Definition
Close proximity; thin walls; many many to allow same volume through (rate decreases by 500x) |
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|
Term
|
Definition
activates a second messenger cGMP which stimulates smooth muscle relaxation; vasodilation |
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|
Term
Endothelin and angiotensin are ligands which activate G-protein coupled receptors which activate... |
|
Definition
Ca++ flux and contraction -> vasoconstriction |
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|
Term
What is causing embryo 1's two heads? |
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Definition
CT1 is upregulating chordin coupled with less BMP produced, chordin antagonizes BMP, ordinarily, too much chordin, gradient gets messed up, development of second dorsal lip, second invagination, causes two-headed embryo |
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