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Unit 2: Chapter 5: Respiratory
Respiratory Intro
41
Pharmacology
Undergraduate 2
01/17/2015

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Term
Anatomy of the Respiratory System
Definition
Components:
Upper and Lower respiratory tracts
Term
Function
Definition
Brings in oxygen into the body
Allows for the exchange of gases
Expels carbon dioxide and other waste products
Term
Structures of Upper Respiratory Tract
Definition
Nose and Nasal Cavity
Sinuses
Mouth
Pharynx
Larynx
Trachea
Bronchi
Term
Info: Upper Respiratory Tract

Ventilation: the movement of air into and out of the boy
Definition
Term
Protective Features of the Upper Respiratory Tract
Definition
*Hair that goes all the way down, filters the air
*Goblet cells produce mucus to trap material (foreign)
*Cilia move the trapped material toward the throat for swallowing
The blood supply close to the surface warms air and adds humidity to improve gas movement and O2 moves more efficiently
The cough and sneeze reflexes clear the airways
Term
Mucus --> drain into the sinus --> nasal cavity --> throat --> GI tract --> stomach acid destroy foreign material
Definition
Term
Cough Reflex
Definition
The walls of the trachea and conducting bronchi are highly sensitive to irritation

When receptors in the walls are stimulated a central nervous system reflex is initiated

Cough causes air to be pushed through the bronchi tree under tremendous pressure clearing the airway of foreign irritant
Term
Reflex
Definition
Initiated by receptors in the nasal cavity

Forces foreign material directly out of the system
---> Opening it for more efficient flow of gases
Term
Info:
Marco phages move through epithelium freely
Definition
Term
Lower Respiratory Tract
Definition
Structures: bronchial tree, bronchioles and the alveoli include the lungs
Term
Respiration
Definition
Gas exchange occurs in the alveoli
Term
Layers of the bronchial tree
Definition
Cartilage --> keeps the tube open
Muscle --> also keeps the tube open
Both get less abundant as bronchi divide and smaller

Epithelial Cells
Term
Gas Exchange
Definition
Occurs the respiratoy membrane in the alveolar sac

2 types cells of the alveoli produce surfacent
Term
surfacent
Definition
decrease surface tension to keep the alveoli open for gas exchange
Term
Process of Respiation
Definition
Controlled through the medulla in the central nervous system

Depends on a balance between the sympathetic and parasympathetic systems

Depends on a functioning muscular system
Term
Controls Over the Respiratory System
Definition
Parasympathetic nerve stimulate the diaphragm contraction and inspiration

Vagal stimulation leads to bronchoconstriction

Sympathetic stiumulation leads to
* increased rate
* depth of respiration
* dilation of bronchi to allow flow of air through the system

Therefore increasing breathing rate when stress to increase O2, used in fight or flight
Term
Upper Respiratory Tract Conditions
Definition
The Common Cold
Seasonal Rhinitis
Sinusitis
Pharyngitis and Laryngitis
Term
The Common Cold
Definition
• Caused a number of viruses
• Viruses invade the tissue of upper respiratory track  initiating the release of histamine causing a an inflammatory response  tissue swell and goblet cells increase production of mucus
o Cause: sinus pain, nasal congestion, runny nose, sneezing, watery eyes, scratchy throat and headache
o Can lead to an ear infection (how?)
Term
Seasonal Rhinitis
Definition
An inflammation of the nasal cavity, commonly called hay fever
Term
Sinusitis
Definition
Inflammation of the epithelial lining of the sinus cavities

Causing swelling against bone.  blockage of sinus passage
Term
Pharyngitis and Laryngitis
Definition
Infections of the pharynx and larynx

Caused by bacteria and virus

Seen frequently with the flu

Causing uncomfortable respiratory symptoms or other inflammation along with fever, muscle aches and pains, and malaise
Term
Lower Respiratory Tract Conditions
Definition
Atelectasis

Pneumonia

Bronchitis
Term
Atelectasis
Definition
Definition
The collapse of once expanded lung tissue
Term
Atelectasis
Occurence
Definition
Result of outside pressure against the alveoli

Most commonly occurs as a result of of blockage of the airway --> prevents air from entering the alveoli --> keeps lung expanded
Term
Atelectasis
Manifestations and Treatment
Definition
crackles, dyspnea, fever, cough, hypoxia, and pain in chest wall

Treatment:
O2 delivery, assisting in ventilation
Term
Pleural Effusion or Pnemonthorax
Definition
Air in the pleural space, exerting high pressure against the alveoli

Treatment: chest tube insertion to restore the negative pressure between the pleura
Term
Pneumonia
Definition
Definition
Inflammation of the lungs caused by bacterial or viral invasion of the tissue
Term
Pneumonia
Causes
Definition
*bacterial or viral invasion of the tissue

*aspiration of foreign substance into the lower respiratory tract, often in stroke patient (loss mechanism to swallow)
Term
Pneumonia
Manifestations
Definition
Localized swelling, engorgement and exudation of protective area

respiratory membrane affected --> decrease in gas exchange
Term
Bronchitis
Definition
Definition
Narrowed airway during the inflammation process
Term
Bronchitis
Causes
Definition
occurs when bacteria, virus, or foreign material infect the inner lining of the bronchi

This causes swelling, blood flow to the are, changes in the capillary permeability, which leakes proteins to the area

Chronic is when this condition doesn't clear
Term
Bronchiectasis
Definition
A chronic disease that involves the bronchi and bronchioles

Characterized by dilation of the bronchial tree and chronic infection and inflammation of the bronchial passages

Inflammation  bronchial epithelial cells are replaced by scare tissue  loss of protective mucus and cilila movement, plus dilation of bronchial tree  chronic infection
Term
Obstructive Pulmonary Diseases
Definition
Asthma
Chronic Obstructive Pulmonary Disease (COPD)
Cystic Fibrosis
Respiratory Distress Syndrome (RDS)
Term
Asthma
Definition
Characterized by reversible bronchospasm, inflammation, and hyperactive airways.

Hyperactive triggered by allergens or non allegric inhaled irritants, or by factors as exercise or emotions
Term
Asthma
Responses
Definition
Immediate response : histamine  bronchospasm

Later response: inflammation, mucus production, and edema  obstruction
Term
Chronic Obstructive Pulmonary Disease (COPD)
Definition
Definition
Permanent, chronic obstruction of airways
Term
Chronic Obstructive Pulmonary Disease (COPD)
Causes
Definition
Often related to cigarette smoking
Emphysema and chronic bronchitis
Term
Chronic Obstructive Pulmonary Disease (COPD)
Manifestations
Definition
*Airway obstruction on expiration

*Overinflated lungs and poor gas exchange

*Emphysema loss of elastic tissue, destruction of alveolar wall, collapse with expiration of wall

* Chronic bronchitis: permanent inflammation with edema, mucus secretion

*characteristics of both disorders are present
Term
Cystic Fibrosis
Definition
A hereditary disease involving the exocrine glands of respiratory, GI and reproductive tracts that results in accumulation of copious of amounts of very thick secretion in the lungs

Secretion eventually obstruct airways, leading to destruction of the airways
Term
Cystic Fibrosis
Definition
A hereditary disease involving the exocrine glands of respiratory, GI and reproductive tracts that results in accumulation of copious of amounts of very thick secretion in the lungs

Secretion eventually obstruct airways, leading to destruction of the airways
Term
Respiratory Distress Syndrome (RDS)
Definition
Causes obstruction at alveolar level
Seen in infants  underdeveloped lungs and low surfactant levels(which is needed for lowereing surface tension causing them to stay open)
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