Term
Epidermal Growth Factor (EGF)
|
|
Definition
4 transmembrane EGF receptors
Ligand stimulation activates tyrosine kinases
Stimulates proliferation of: epithelial cells, hepatocytes, and fibroblasts
Inflammation, repair, and renewel
excessive signaling -> cancer |
|
|
Term
| Hepatocyte Growth Factor (HGF) |
|
Definition
c-MET receptor
causes proliferation of hepatocytes and epithelial cells
imp in embryonic development
activated by proteolytic cleavage
overexpression of c-MET -> cancer |
|
|
Term
| Platelet Derived Growth Factor (PDGF) |
|
Definition
5 dimers (AA, AB, BB, CC, and DD)
receptors: alpha, beta with varying ligand specificities
proliferation of fibroblasts, SM cells, and monocytes
imp in wound healing
over expression of PDGF -> cancer |
|
|
Term
| Vascular Endothelial Growth Factor (EVGF) |
|
Definition
3 receptors that are dimers
VEGF-1 unknown, VEGF-2 in endothelial cells, VEGF-3 in lymphatic vessels
causes preliferation of new blood vessels
angiogenic signals in inflammation and some cancers |
|
|
Term
| Fibroblast Growth Factor (FGF) |
|
Definition
80 possible combos of receptors and factors
FGF-1 = acidic
FGF-2 = basic
ligand binding activates tyrosine kinase
wound healing, angiogenesis, hematopoiesis, devo |
|
|
Term
| Transforming Growth Factor Beta (TGF-B) |
|
Definition
proteolysis of TGFB
homodimers produced by platelets, macrophages, endothelia, and lymphocytes
serine/threonine kinase
phos of smad transcription factors
smads dimerize
translocate to the nucleus
transcriptional regulation
inhibits growth of epithelial cells - opposite of others
anti-inflammatory effect
fibroblast chemotaxis: collagen, fibronectin, proteoglyc |
|
|
