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Dysplasia (Atipical Hyperplasia) |
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Increase in cell numbers that are becoming undifferentiated |
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A cell type that changes to a different cell type |
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Occurs mostly in uterus or breast |
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Definition
Lack of sufficient oxygen Number one reason for cellular injury |
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Can replicate and can grow back after dead or injured |
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Cannot replicate (Neurons, Cardiac Myoocytes) and once dead will never grow back |
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Decrease in ATP, causing failure of sodium-potassium pump and sodium-calcium exchange; Cellular swelling |
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Definition
Electrically uncharged atom or group of atoms having an unpaired electron that damage:Alteration of proteins, Alteration of DNA, Mitochondrial damage |
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Infiltrates the blood, and increases intracellular calcium concentration |
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Has an affinity for hemoglobin 300x that of O2 Skin will be bright red, O2 saturation will be 98%-100%, they will have altered mental status or severe headache, and HR BP and RR will be elevated |
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Lead, carbon monoxide, ethanol (ETOH) |
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Caused nowadays by fish and dental amalgams |
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Opioid, Sedative Hypnotic, Psychomotor Stimulants, Phencyclidine-like drugs, Cannabinoids, Hallucinogens |
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Definition
Application of mechanical energy to the body resulting in the tearing, shearing, or crushing of tissues Contusion(Bruise) vs. hematoma(collection of blood), Abrasion(Scrape), Laceration(Jagged cut), Fractures |
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Definition
Incised wounds Stab wounds Puncture wounds Chopping wounds |
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Definition
KE(kinetic injury) = ½ MV2 Entrance wounds: Contact range entrance wound Blow-back and muzzle imprint Intermediate range entrance wound Tattooing and stippling Indeterminate range entrance wound Exit wounds Shored exit wound |
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Failure of cells to receive or utilize oxygen appropriately Suffocation (choking asphyxiation), Strangulation (hanging), Chemical asphyxiation (cyanide and hydrogen sulfide), Drowning |
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Definition
Thymus gland shrinking (expected) |
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Disuse atrophy (unexpected) |
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Hypertrophy and cardiomegaly due to the heart having to work harder. |
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Definition
Metaplasia; can turn into dysplasia and cancer |
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Definition
Hyperplasia to make up for the lost tissue |
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Definition
Infiltrations; Accumulate in a cell unnaturally Water, lipids, carbohydrates, glycogen, proteins, pigments, calcium, urate |
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Primary inflammatory mediator |
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Sum of cellular changes after local cell |
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Kidneys, heart, adrenal glands Protein denaturation |
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Neurons and glial cells of the brain Hydrolytic enzymes Bacterial Infection (Staph, Strep, E-Coli) |
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Tuberculosis pulmonary infection Combination of coagulative and liquefactive necrosis |
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Definition
Breast, pancreas, and other abdominal organs Action of lipases |
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Definition
Death of tissue from severe hypoxic injury Dry vs. wet gangrene (Clostridium) |
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Term
Accumulation of injurious events |
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Definition
Theory of aging that states that accumulation of oxidants causes aging |
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Genetically controlled program |
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Definition
Theory of aging that states that every time a cell divides we lose little pieces of information |
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Definition
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Wasting away of muscle tissue |
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Death of an entire person |
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Decreased temperature, respiratory decrease, mottling |
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Algor mortis(cooling of the body), Livor mortis(mottling), Rigor mortis(hardening), Postmortem autolysis |
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