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UMICH Biology 222 (Exam 3)
Material that will be covered on exam 3 (2011)
26
Biology
Undergraduate 3
11/18/2011

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Term
Pacinian Corpuscle
Definition
- Largest mechanoreceptor
- Sensitive to high frequency vibration (facilitates tool use)
- Low spatial acuity
- Large receptive field size, rapid adaptation
Term
Ruffini's endings
Definition
- Second largest receptor
- Sensitive to skin stretch from finger movement (information about finger and hand position)
- Low spatial acuity, slow adaptation
Term
Meissner's corpuscle
Definition
- 1/10th size of pacinian corpuscle
- Sensitive to low frequency vibration
- Intermediate spatial acuity
- Small receptive field size, rapid adaptation
Term
Merkel's disk
Definition
- Smallest receptor
- Sensitive to edges, points, curvature (detect form and texture)
- High spatial acuity
- Slow adaptation
Term
Internal arcuate fibers (dorsal column-medial lemniscal pathway)
Definition
Part of the second order neurons that crossover (in caudal medulla)
Term
Name of the structure that contain cells that the medial lemniscus synapses with (dorsal column-medial lemniscal pathway)
Definition
Ventral posterior (VP) nucleus of the thalamus
Term
The name of the neurons (and order) that project to the primary somatosensory cortex (S1) (dorsal column-medial lemniscal pathway)
Definition
VP neurons (third order)
Term
Nociceptor
Definition
Free nerve endings of Aδ fibers and unmyelinated C axons
Term
Bradykinin
Definition
- Activates nociceptors
- Made by enzyme released from damaged cells
- Directly activates nociceptors via depolarization through G-protein coupled receptor
Term
ATP
Definition
- Activates nociceptors
- Made by an enzyme released from damaged cells
- Directly activates P2X receptors (ionotropic)
Term
Potassium (K+)
Definition
- Activates nociceptors
- Released from damaged cells
- Depolarizes nociceptors
Term
Hyperalgesia
Definition
Following injury, injury site and surrounding area have increased perception of pain
Term
Sensitization
Definition
Exposure of nociceptors to products of tissue damage increases their activity and their sensitivity to stimuli
Term
Bradykinin (sensitization)
Definition
- Sensitize nociceptors
- Increases sensitivity of ion channels like TRPV1
Term
Prostaglandins
Definition
- Made by an enzyme (cyclooxygenase) released from damaged cells
- NSAIDS inhibit this enzyme
Term
Substance P
Definition
- Sensitizes nociceptors
- RELEASED from nociceptors
- Causes swelling of the capillaries (vasodilation)
- Causes release of histamine (which causes membrane depolarization) from mast cells
Term
Periaqueductal gray matter (PAG)
Definition
- A zone of neurons in the midbrain that, when stimulated, produces analgesia.
- Sends descending axons into raphe nuclei of medulla, among other midline areas of medulla.
Term
Raphe nuclei
Definition
- Its neurons descend and synapse with second order projection neurons in the dorsal horn
Term
Fungiform papillae
Definition
- Type of papillae on anterior 2/3 of tongue
Term
Foliate papillae
Definition
- Type of papillae on the posterior lateral edge of the tongue
Term
Vallate papillae
Definition
- Type of papillae located on the back of the tongue
Term
Population coding
Definition
- Required for across-fiber model
- Responses of a large number of broadly tuned neurons specifies taste
Term
Anosmia
Definition
The inability to detect a common odor
Term
What are the systems involved in pheremone detection
Definition
- Vomeronasal organ
- Grueneberg ganglion
Term
Four components of the olfactory epithelium
Definition
- Olfactory receptor neuron cells (neuronal as opposed to taste receptor cells)
- Supporting cells (detoxify toxins in mucus, contribute to mucus)
- Basal cells (source of new ORN cells)
- Bowman's gland (produces mucus)
Term
Endolymph
Definition
- Found in cochlea and vestibular labyrinth (bony structures of inner ear)
- Contains a high concentration of potassium and a low concentration of sodium
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