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UMDNJ-SOM pharm autonomics exam 1
ohhhh vogel
60
Pharmacology
Graduate
08/23/2010

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Cards

Term
Ach
Definition
+, short direct acting, PSmimetic
Term
bethanechol
Definition
+, long direct acting PSmimetic
Term
methacholine
Definition
+, long direct acting PSmimetic
Term
carbachol
Definition
+, long direct acting PSmimetic
Term
pilocarpine
Definition
natural, direct acting, PSmimetic
Term
muscarine
Definition
+ natural, direct acting, PSmimetic
Term
edrophonium
Definition
+, reversible short acting, anticholinesterase
Term
physostimine
Definition
reversible, natural, longer acting, anticholinesterase
Term
neostigmine
Definition
+, reversible longer acting, anticholinesterase
Term
pyridostigmine
Definition
+, reversible longer acting, anticholinesterase
Term
DFP, isofluorophate, organophosphate
Definition
irreversible anticholinesterase
Term
nicotine
Definition
in small doses, ganglionic agonist. in large doses, ganglionic antagonist
Term
trimethaprin
Definition
ganglionic antagonist
Term
atropine
Definition
natural competitive M blocker
Term
scopolamine
Definition
natural competitive M blocker
Term
ipratopium
Definition
synthetic competive M blocker (some ganglionic blocking activity)
Term
tiotropium
Definition
+, synthetic competive M blocker (some ganglionic blocking activity)
Term
propantheline
Definition
+, synthetic competive M blocker (some ganglionic blocking activity)
Term
tropicamide
Definition
synthetic competive M blocker (some ganglionic blocking activity)
Term
cyclopentolate
Definition
synthetic competive M blocker (some ganglionic blocking activity)
Term
norepinephrine
Definition
exogenous, catecholamine, direct on alpha's, some beta1
Term
epinephrine
Definition
exogenous, catecholamine, direct on all A's and B's
Term
isoproterenol
Definition
catecholamine, direct on B's
Term
dopamine
Definition
exogenous, catecholamine, direct on all A's and B's and DA (dilate renal vessels)
Term
dobutamine
Definition
catecholamine- direct on B1
Term
phenylepineprhine
Definition
non-cat, direct on A1
Term
tetrahydrozoline
Definition
non-cat, direct on A1
Term
naphazoline
Definition
non-cat, direct on A1
Term
oxymetazoline
Definition
non-cat, direct on A1
Term
clonidine
Definition
non-cat, direct on A2
Term
ritodrine
Definition
non-cat, direct B2> B1
Term
metaproterenol
Definition
non-cat, direct B2> B1
Term
albuterol
Definition
non-cat, direct B2> B1
Term
salbutamol
Definition
non-cat, direct B2> B1
Term
salmeterol
Definition
non-cat, direct B2> B1
Term
formoterol
Definition
non-cat, direct B2> B1
Term
terbutaline
Definition
non-cat, direct B2> B1
Term
ephedrine
Definition
indirect, increased NE release, easily cross BBB
Term
pseudoephedrine
Definition
indirect, increased NE release
Term
amphetamine
Definition
indirect, increased NE release, easily cross BBB
Term
cocaine
Definition
indirect, decreased uptake of NE
Term
prazosin
Definition
block A1
Term
tamsulosin
Definition
block A1
Term
doxazosin
Definition
block A1
Term
phentolamine
Definition
blocks all A, competitive, short
Term
phenoxybenzamine
Definition
blocks all A's, irreversible
Term
propranolol
Definition
blocks both B's
Term
timolol
Definition
blocks both B's
Term
nadolol
Definition
blocks both B's (least lipophilic)
Term
metoprolol
Definition
cardioselective, blocks B1, (B2 at high dose)
Term
acebutolol
Definition
cardioselective, blocks B1, (B2 at high dose)
Term
atenolol
Definition
cardioselective, blocks B1, (B2 at high dose)
Term
labetalol
Definition
vasodilator- A and B blocker
Term
pindolol
Definition
partial B agonist (acitivty depends on state)
Term
carteolol
Definition
partial B agonist, activity depends on state
Term
d-tubocurarine
Definition
natural, competitive, non depol NMJ blocker (20 minutes), reversed by anticholinesterase
Term
mivacuronium
Definition
competive, non depol NMJ blocker (hour), reversed by anticholinesterase
Term
pancuronium
Definition
competive, non depol NMJ blocker (hour), reversed by anticholinesterase
Term
succinylcholine
Definition
depolarizing, NMJ blocker anticholinesterase doesn’t help (minutes)
Term
botulinus toxin
Definition
Ach release inhibitor, irreversible paralysis, sx's releived after new ones made
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