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UMB Pediatric Pharmacology - Asthma
P3 - Exam 1
24
Pharmacology
Professional
10/03/2016

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Cards

Term
How long should asthma be controlled before stepping down therapy?
Definition
3 months
Term
After stepping up asthma therapy when should follow up be scheduled?
Definition
4-6wks
Term
What two things should be checked before stepping up asthma therapy?
Definition
1. adherence
2. environmental
Term
To treat VERY poorly controlled asthma in 5-11yo consider:
Definition
1. Short course of oral corticosteroid
2. 1-2 step ups in therapy
Term
Describe VERY poorly controlled asthma in 5-11yo
Definition
1. Nighttime awakening 2 times a week
2. Normal activities extremely limited
3. SABA use daily
4. FEV1 <75% predicted; <60% predicted personal best
5. symptoms throughout ea. day
Term
Describe WELL controlled asthma in 5-11yo
Definition
1. Symptom 2 days a week; less than 1/day
2. nighttime awakening <1/month
3. SABA 2 days/wk
4. No interference w/ normal activity
5. FEV1 >80% predicted/predicted personal best
Term
What does Step 1 asthma treatment look like for 5-11yo?
Definition
Preferred: SABA PRN
Term
Describe step 2 asthma treatment for 5-11yo
Definition
Preferred: Low dose ICS

Alternate:
LTRA
Cromolyn
Theophyline
Term
Describe step 4 asthma treatment for 5-11yo
Definition
Preferred: Med dose ICS + LABA

Alternate:
Med dose ICS+LTRA
Med doe ICS+Theophiline
Term
Describe step 5 asthma treatment for 5-11yo
Definition
Preferred: High dose ICS+LABA

Alternate:
High dose ICS+LTRA
High DOSE ICS+Theophiline
Term
Describe step 3 asthma treatment for 5-11yo
Definition
Preferred: Med dose ICS+LABA
Med dose ICS + LTRA
Med dose ICS + Theophyiline

Alternate:
MED dose ICS
Term
Describe step 6 asthma treatment for 5-11yo
Definition
Preferred: High dose ICS+LABA+oral corticosteroid

Alternate:
High dose ICS+LTRA+oral corticosteroid
High DOSE ICS+Theophiline+oral corticosteroid
Term
How does classification of asthma (well controlled, not well controlled, poorly controlled) differ in 0-4yo from 5-11yo?
Definition
FEV1 is not considered
Term
How does step therapy of asthma differ in 0-4yo from 5-11yo?
Definition
Step 3 = Med dose ICS only
Step 4 = Med dose ICS+LABA or Singulair
Step 5 = High dose ICS+LABA or Singulair
Step 6= HIGH dose ICS+LABA or singulair +oral corticosteroid
Term
Badger study take ways about asthma?
Definition
African Americans: LABA or ICS; LTRA least effective
White: LABA; ICS add-on least favorable
Term
Per the asthma rules of two asthma is not controlled if:
Definition
Daytime symptom 2/wk
Nocturnal symptoms 2/mo
More than 2 SABA canisters used/yr
More than 2 courses of ICS/yr
Term
Common dosing for fluticasone MDI in peds age 0-11:
Definition
Low 88-176mcg
Med 176-352
High >352
Term
Common dosing for mometasone DPI in peds age 5-11; not indicated for 0-4yo?
Definition
L: 110mcg
M: 220
H: >440
Term
Aside from Fluticasone MDI peds 0-4yo can also use____________ at what doses
Definition
Budesonide Nebs
L: 500mcg
M:1000
H: >1000 for 0-4; 2000 for 5-11
Term
T/F Cromolyn and Theophyline are not used in peds 0-4yo
Definition
True
Term
List 2 LTRA (Leukotriene receptor antagonists) agents
Definition
Montelukast (sold as Singulair®)
Zafirlukast (sold as Accolate®)
Term
How does step 3 therapy differ between 0-4yo and 5-11yo?
Definition
5-11 alternate (Med dose ICS) is 0-4yo only treatment option.

5-11 yo preferred (Low dose ICS+LABA/LTRA+Theophiline) is not an option for 0-4yo
Term
What is the only LTRA recommended for 0-4yo in steps 4, 5 and 6?
Definition
montelukast (singulair)
Term
How does step 4-6 therapy differ between 0-4yo and 5-11yo?
Definition
Theophilie is not an option for 0-4yo
The only LTRA agent 0-4 can use is singulair.
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