Term
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Definition
| Pyruvate is dehydrated via pyruvate dehydrogenase to form Acetyl-CoA . 1 ATP produced = irreversible |
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Term
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Definition
| Acetyl-CoA interacts with enzyme citrate synthase to form citrate |
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Term
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Definition
| Citrate is rearranged to form cis-aconitate and then isocitrate |
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Term
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Definition
| Isocitrate reacts with isocitrate dehydrogenase to form alpha-ketoglutarate. Uses 1 ATP, produces 1 ATP, 1 NADH, CO2 |
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Term
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Definition
| Alpha-ketoglutarate is oxidized via alpha-KG dehydrogenase, CO2 is removed, and coenzyme A is added to form the 4-carbon compound succinyl-CoA. During this oxidation, NAD+ is reduced to NADH + H+ |
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Term
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Definition
| CoA is removed from succinyl-CoA to produce succinate. The energy released is used to make guanosine triphosphate (GTP) from guanosine diphosphate (GDP) and Pi by substrate-level phosphorylation. GTP can then be used to make ATP |
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Term
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Definition
| Succinate is oxidized to fumarate. FADH2 is produced |
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Term
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Definition
| Fumarate + water forms malate. |
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Term
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Definition
| Malate is oxidized to form oxaloacetate (brings back to beginning to re-form citrate with Acetyl CoA). NADH is formed |
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