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trueger
immuno path
34
Other
Not Applicable
06/03/2006

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Term
serum sickness
Definition
hypersens type 3
abs to proteins -> Ics
depos in membranes, fix compl->
tissue dmg

usual etio: Rx

Term
arthus rxn
Definition
local subacute hypersens 3
intradermal ag -> abs ->
edeme, necr, actn of complement
ex: farmer slung, thermophilic actinomycetes
Term
hypersens type 3
abs to proteins -> Ics
depos in membranes, fix compl->
tissue dmg

usual etio: Rx

Definition
serum sickness
Term
local subacute hypersens 3
intradermal ag -> abs ->
edeme, necr, actn of complement
ex: farmer slung, thermophilic actinomycetes
Definition
arthus rxn
Term
type 1 hypersens eg
Definition
anaphylaxis
asthma
hives
local wheal & flare
Term
anaphylaxis
asthma
hives
local wheal & flare
Definition
type 1 hypersens eg
Term
type 3 immune complex exs
Definition
PAN, IC GN, SLE, RA
Term
PAN, IC GN, SLE, RA
Definition
type 3 immune complex exs
Term
brutons agamma
Definition
XR TK -> dn all Igs
b cells
bac infns post 6 mos (dn maternal Ig)
Term
thymic aplasia
Definition
digeorge
t cells
3/4th pouch issues
tetany: hypoCa
viral/fungal
heart & great vessel congen defs
22q11
Term
SCID
Definition
b&t cell
defect in early stem cell diff
recurrent viral, bac, prot & fungal
(mhc 2 issuess, def il2r, ad deam def)
Term
XR TK -> dn all Igs
b cells
bac infns post 6 mos (dn maternal Ig)
Definition
brutons agamma
Term
digeorge
t cells
3/4th pouch issues
tetany: hypoCa
viral/fungal
heart & great vessel congen defs
22q11
Definition
thymic aplasia
Term
b&t cell
defect in early stem cell diff
recurrent viral, bac, prot & fungal
(mhc 2 issuess, def il2r, ad deam def)
Definition
SCID
Term
il2r def
Definition
dissem mycobac infn
t cell
Term
hyper igm
Definition
b cell
CD40L def -> no class switching
early pyogenic infns
Term
wiskott aldrich
Definition
b cell
XR dn IgM to caps polysacchs -> up IgA
Infections, thrombocytopenic Purpura
exzema
Term
dissem mycobac infn
t cell
Definition
il2r def
Term
b cell
CD40L def -> no class switching
early pyogenic infns
Definition
hyper igm
Term
b cell
XR dn IgM to caps polysacchs -> up IgA
Infections, thrombocytopenic Purpura
exzema
Definition
wiskott aldrich
Term
jobs syndrome
Definition
inact macs
failure if infgamma prodn by Th cells
PMNs fail to respond to chemotactics
recurrent "cold" - non inflammed staph abscesses, eczema, coarse facies, retained prim teeth, high IgE
Term
inact macs
failure if infgamma prodn by Th cells
PMNs fail to respond to chemotactics
recurrent "cold" - non inflammed staph abscesses, eczema, coarse facies, retained prim teeth, high IgE
Definition
jobs syndrome
Term
LFA-1 def
Definition
phags lack LFA-1 -> early severe pyogenic & fungals, del'd sep of umbilicus
Term
phags lack LFA-1 -> early severe pyogenic & fungals, del'd sep of umbilicus
Definition
LFA-1 def
Term
chediak higashi
Definition
AR
microtubule formn defect -> dn lysosomal emptying of phag cells
recur staph & strep pyogen infns
ptl albinism, periph neuropathy
Term
AR
microtubule formn defect -> dn lysosomal emptying of phag cells
recur staph & strep pyogen infns
ptl albinism, periph neuropathy
Definition
chediak higashi
Term
chr gran dz
Definition
NADPH ox def
bac: staph aur, e coli, aspergillus
dx: neg nitroblue tetrazolium dye redn test
Term
NADPH ox def
bac: staph aur, e coli, aspergillus
dx: neg nitroblue tetrazolium dye redn test
Definition
chr gran dz
Term
chr mucocutan candida
Definition
t cell dysfn only w. candida alb
skin & muc membr candida infns
Term
t cell dysfn only w. candida alb
skin & muc membr candida infns
Definition
chr mucocutan candida
Term
selective Ig def
Definition
isotype switching issues?
IgA biggest prob
sinus, lung infns
milk allergy & D are common
Term
isotype switching issues?
IgA biggest prob
sinus, lung infns
milk allergy & D are common
Definition
selective Ig def
Term
ataxia telangiectasia
Definition
DNA repair def -> IgA def
CB ataxia & spider angiomas
Term
DNA repair def -> IgA def
CB ataxia & spider angiomas
Definition
ataxia telangiectasia
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