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trueger
renal phys 2
52
Other
Not Applicable
05/22/2006
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Term
what releases renin?
 Definition
JG cells when dn BP
Term
what does renin do?
 Definition
cleaves angiotensinogen-> AT1
Term
what does does AT1 do?
 Definition
ACE: AT1-ATII
prim in lung caps
Term
JG cells when dn BP
 Definition
what releases renin?
Term
cleaves angiotensinogen-> AT1
 Definition
what does renin do?
Term
ATII actions
 Definition
vasoconstr
rel aldo from adr cortex
rel ADH fr pos pit
stim hypoth -> up thirst
Term
ATII general
 Definition
up BV & up BP
Term
ANP role
 Definition
act as "check" on R-A-A
e.g. in CHF
Term
JG cells
 Definition
modified sm mm of aff arteriole
Term
macula densa cells
 Definition
Na sensor on DCT
Term
modified sm mm of aff arteriole
 Definition
JG cells
Term
Na sensor on DCT
 Definition
macula densa cells
Term
endocrine kidney
 Definition
EPO (endoth cells of peritubular caps in hypoxia)
vit d a1hydrox (actd by PTH)
JG-> renin w.dn pressure or up b1 SNS
PGs that vasodilate affs to up GFR
Term
NSAID-> RF
 Definition
high vasoconstr states + NSAIDS -> blocks PGs from dilating affs
Term
ANP affect on kidney
 Definition
up atr pressure-> up GFR, up Na excr
Term
aldo ->
 Definition
up Na R, K S, H+ S
Term
up atr pressure-> up GFR, up Na excr
 Definition
ANP affect on kidney
Term
up Na R, K S, H+ S
 Definition
aldo ->
Term
PTH->
 Definition
up Ca R in DCT
dn phos R in DCT
up vit D prodn -> up Ca & phos R
Term
up Ca R in DCT
dn phos R in DCT
up vit D prodn -> up Ca & phos R
 Definition
PTH->
Term
ATII ->
 Definition
eff constr -> up GFR -> up Na & bicarb R
Term
ADH ->
 Definition
up water channels and up water R
Term
eff constr -> up GFR -> up Na & bicarb R
 Definition
ATII ->
Term
up water channels and up water R
 Definition
ADH ->
Term
dn pH, dn pCO2, dn bicarb
comp: hypervent
 Definition
met acidosis levels
Term
met acidosis levels
 Definition
dn pH, dn pCO2, DN bicarb
comp: hypervent
Term
met alkalosis levels
 Definition
up pH, up pCO2, UP bicarb
comp: hypovent
Term
up pH, up pCO2, UP bicarb
comp: hypovent
 Definition
met alkalosis levels
Term
resp acidosis levels
 Definition
dn pH, UP pCO2, up bicarb
comp: renal bicarb R
Term
dn pH, UP pCO2, up bicarb
comp: renal bicarb R
 Definition
resp acidosis levels
Term
resp alk levels
 Definition
up pH, DN pCO2, dn bicarb
comp: renal bicarb S
Term
up pH, DN pCO2, dn bicarb
comp: renal bicarb S
 Definition
resp alk levels
Term
henderson hasselbach
 Definition
pH=pK+logbicarb/.03pCO2
Term
pH <7.4, pCO2>40
 Definition
resp acidosis
Term
resp acidosis
 Definition
pH <7.4, pCO2>40
Term
pH <7.4, pCO2<40
 Definition
met acidosis w. resp comp
Term
met acidosis w. resp comp
 Definition
pH <7.4, pCO2<40
Term
pH >7.4, pCO2<40
 Definition
resp alk
Term
resp alk
 Definition
pH >7.4, pCO2<40
Term
pH >7.4, pCO2>40
 Definition
met alk w. resp comp
Term
causes of resp acidosis
 Definition
hypovent
airway obstr, ac lung dz, chr lung dz, opiods, narcotics, sedatives, wk resp mm
Term
causes of up anion gap met acidosis
 Definition
MUDPILES
methanol, uermia, DKA, paraldehyde or phenformin, Iron or INH, Lac acid, Ethylene gylcol, Salicylates
Term
MUDPILES
methanol, uermia, DKA, paraldehyde or phenformin, Iron or INH, Lac acid, Ethylene gylcol, Salicylates
 Definition
causes of up anion gap met acidosis
Term
causes of resp alk
 Definition
hyperv, ASA (early)
Term
causes of met alk
 Definition
V, Diurtic use, antacids, hyperaldo
Term
causes of nl anion gap met acidosis
 Definition
D, glue sniffing, RTA, hyperCl
Term
met acid comp
 Definition
pCO2 dn 1.2 x (bicarb)
Term
met alk comp
 Definition
pCO2 up 0.7 x (bicarb)
Term
ac resp acid comp
 Definition
bicarb up .1 x(pCO2)
Term
chr resp acid comp
 Definition
bicarb up .4 x(pCO2)
Term
ac resp alk comp
 Definition
bicarb dn .2 x(pCO2)
Term
chr resp alk comp
 Definition
bicarb dn .4 x(pCO2)
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