Term
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Definition
synergistic combo of folate antagonists blocks purine production and nucleic acid synthesis |
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Term
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Definition
bactericidal against susceptible bacteria |
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Term
TMP-SMX: clinical applications? |
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Definition
PCP pneumonia, UTIs, toxoplasmosis, nocardiosis |
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Term
How TMP-SMX be given? How is it cleared? What is the ratio? Tox? |
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Definition
oral or IV, renally, 1:5 TMP:SMX, rash, fever, BM suppression, hyperkalemia |
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Term
Sulfisoxazole: How is it given? What is it used for? |
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Definition
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Term
Sulfadiazine: How is it given? What is it used for? |
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Definition
oral, toxoplasmosis (combined with pyrimethamine) |
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Term
Trimethoprim: How is it given? What is it used for? Is it safe for pts with sulfonamide allergy? |
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Definition
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Term
Pyrimethamine: How is it given? What is it used for? What is coadministered? |
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Definition
oral, toxoplasmosis when combined with sulfadiazine, coadmin with leucovorin to limit BM toxicity |
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Term
Pyrimethamine-sulfadoxine: How is it given? It is second line treatment for what? |
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Definition
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Term
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Definition
inhibits DNA replication by binding DNA gyrase and topoisomerase IV |
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Term
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Definition
bactericidal against susceptible bacteria |
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Term
Ciprofloxacin: clinical applications? |
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Definition
UTIs, gastroenteritis, osteomyelitis, anthrax |
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Term
Ciprofloxacin: How is it given? How is it cleared? What impairs absorption? Toxicity? |
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Definition
oral and IV, mixed clearance, di and tr-valent cations impair oral abs, tox- GI upset, neurotox, tendonitis |
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Term
Ofloxacin: How is it given? What is it used for? |
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Definition
oral, onkly for UTIs and non-gon urethritis and cervicitis |
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Term
Levofloxacin: How is it given? What is it used for? |
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Definition
oral and IV, L-isomer of ofloxacin, once daily dosing, renal clearance, "respiratory" fluoroquinolone with better activity against pseudomonas |
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Term
Moxifloxacin: How is it given? What is it used for? |
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Definition
oral and IV, "respiratory" fluoroquinoline, once daily dosing, better for anaerobes and TB, hepatic clearance - lower urinary levels, not used for UTIs |
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Term
Gemifloxacin: How is it given? What is it used for? |
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Definition
oral, "respiratory fluoroquinolone" |
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