Shared Flashcard Set

Details

Trimethoprim, Sulfonamides and Fluoroquinolines
Antibiotics
17
Pharmacology
Professional
10/13/2011

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Cards

Term
TMP-SMX: MOA?
Definition
synergistic combo of folate antagonists blocks purine production and nucleic acid synthesis
Term
TMP-SMX: effects?
Definition
bactericidal against susceptible bacteria
Term
TMP-SMX: clinical applications?
Definition
PCP pneumonia, UTIs, toxoplasmosis, nocardiosis
Term
How TMP-SMX be given? How is it cleared? What is the ratio? Tox?
Definition
oral or IV, renally, 1:5 TMP:SMX, rash, fever, BM suppression, hyperkalemia
Term
Sulfisoxazole: How is it given? What is it used for?
Definition
oral, UTIs
Term
Sulfadiazine: How is it given? What is it used for?
Definition
oral, toxoplasmosis (combined with pyrimethamine)
Term
Trimethoprim: How is it given? What is it used for? Is it safe for pts with sulfonamide allergy?
Definition
oral, lower UTIs, yes
Term
Pyrimethamine: How is it given? What is it used for? What is coadministered?
Definition
oral, toxoplasmosis when combined with sulfadiazine, coadmin with leucovorin to limit BM toxicity
Term
Pyrimethamine-sulfadoxine: How is it given? It is second line treatment for what?
Definition
oral, malaria
Term
Ciprofloxacin: MOA?
Definition
inhibits DNA replication by binding DNA gyrase and topoisomerase IV
Term
Ciprofloxacin: effects?
Definition
bactericidal against susceptible bacteria
Term
Ciprofloxacin: clinical applications?
Definition
UTIs, gastroenteritis, osteomyelitis, anthrax
Term
Ciprofloxacin: How is it given? How is it cleared? What impairs absorption? Toxicity?
Definition
oral and IV, mixed clearance, di and tr-valent cations impair oral abs, tox- GI upset, neurotox, tendonitis
Term
Ofloxacin: How is it given? What is it used for?
Definition
oral, onkly for UTIs and non-gon urethritis and cervicitis
Term
Levofloxacin: How is it given? What is it used for?
Definition
oral and IV, L-isomer of ofloxacin, once daily dosing, renal clearance, "respiratory" fluoroquinolone with better activity against pseudomonas
Term
Moxifloxacin: How is it given? What is it used for?
Definition
oral and IV, "respiratory" fluoroquinoline, once daily dosing, better for anaerobes and TB, hepatic clearance - lower urinary levels, not used for UTIs
Term
Gemifloxacin: How is it given? What is it used for?
Definition
oral, "respiratory fluoroquinolone"
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