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transplant & tumor immunology
immunology ch. 17&18
28
Medical
Undergraduate 1
05/04/2010

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Cards

Term
source of tissue in autograft
Definition
self
Term
source of tissue in syngraft
Definition
identical twin
Term
source of tissue in allograft
Definition
same species
Term
source of tissue in xenograft
Definition
diff. species
Term
list 4 types of graft rejection
Definition
hyperacute, acute, accelarated (early), & chronic
Term
graft rejection occurs w/i mins (fastest)
-caused by pre-formed ab's
-rare but extremely dangerous
ex:ABO
Definition
hyperacute
Term
graft rejection occuring w/i 1st cpl days
-in response to 2nd transfusion
ex: pt gets blood and then has 2nd transfusion a few days later after forming ab's to that blood causing a rxn
Definition
accelarated (early)
Term
graft rejection that can take up to several months
-cell mediated; CD8 cells are attacking donated tissue
Definition
acute
Term
graft rejection that takes the longest to present
-cell mediated; caused by progressive fibrosis and scarring of the artery, loss of O2 causes tissue death
Definition
chronic
Term
list 3 types of tests used in tissue matching
Definition
CDC-comp dependant cytotoxicity, Elisa, single cell analysis by flow cytometry
Term
which organ transplant is performed most often in US
Definition
kidney
Term
what compatibility tests are done before renal transplantation
Definition
ABO & HLA
Term
name the only compatibility test required for heart, lung, and liver transpants
Definition
ABO
Term
in BM transplants, matching of these Ags are the most important
Definition
HLA class one Ags
Term
what is graft vs host (gvh) and how is it prevented
Definition
tcells from trans tissue attacks host-prevention by hla typing and gamma irradiation
Term
define cancer
Definition
a cell that has proliferated past normal tissue boundaries
Term
another name for cancer/tumor cells
Definition
neoplastic cells
Term
why are tumor markers only used in screeninf for cancer
Definition
they are not specific enough
Term
list 4 cells that respond to infiltrating tumors
Definition
lymphocytes
macrophages
granulocytes
mast cells
Term
hcg & afp = what cancer
Definition
testicular cancer
Term
cea = what cancer
Definition
colon
Term
CA15.3 & BR27.29
Definition
breast
Term
estrogen/progesterone receptors are tumor markers associated with what type of cancer
Definition
breast cancer
Term
CA125
Definition
ovarian
Term
CA19-9
Definition
pancreatic (&colon)
Term
PSA
Definition
prostate (prostate specific)
Term
calcitonin is the tumor marker associated with which type of cancer
Definition
thyroid
Term
why is eia the method of choice for detecting tumor markers
Definition
it's sensitivity
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