Term
| Corynebacterium diphtheriae |
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Definition
- gram+ aerobic pleomorphic bacillus
- toxin
- simple AB
- iron regulated
- ADP-ribosylates EF-2 --> prevents protein synthesis
- vaccine
- antitoxin + antibiotics
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Term
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Definition
- small, gram- coccobacillus
- fastidious, slow growing
- virulence
- adhesins (filamentous hemagglutinin)
- adenylate cyclase toxin --> ↑ cAMP
- pertussis toxin
- complex AB
- inhibits Gi --> stimulates host AC --> ↑ cAMP
- vaccine
- antibiotics (early is best)
- supportive care
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Term
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Definition
- gram+ obligate aerobe
- colonies have fruity odor, blue-green
- opportunistic
- virulence
- alginate - slime layer
- pili
- Exo S - ADP ribosylates G proteins
- Exo A - simple AB, ADP ribosylates EF2
- aggresive use of two antibiotics (resistance)
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Term
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Definition
- gram+ slender anaerobic, spore forming rod
- toxin
- simple AB
- A is enteropeptidase --> blocks release of inhibitory neurotransmitters --> continuous stimulation --> spastic paralysis and lockjaw
- vaccine
- debridement, isolation, antitoxin, antibiotic
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Term
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Definition
- gram+ anearobic spore-forming rod
- food borne intoxication, infant, wound
- toxin
- simple AB
- A is endoprotease that degrades proteins required for release of Ach at neuromuscular jxn --> flaccid paralysis
- slurred speech, dysphagia, visual disturbances, cardiac and respiratory arrest
- anti-botulism Ig for intox, antiobiotic for infant and wound
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Term
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Definition
- gram+ abligate anaerobe, stout truncated spores
- virulence
- α toxin - lecithinase C --> membrane disruption
- enterotoxin
- degradative enzmes
- gas gangrene - foul smelling necrosis
- surgical debridement, penicillin IV
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