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Airway patent breathing circulatory/bleeding disabled neurologically exposed to chemicals or cold |
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Alert Voice response Pain Response No response |
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Coma cocktail Dextrose Oxygen naloxone thiamine |
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organic pyrophosphate herbicides |
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Activated charcoal (10X weight injested) preferred.
Additional methods: Gastro lavage = trauma during tubation vomiting = aspiration pneumonitis
Poorly absorbed to charcoal: Fe and Li
really concerned: Ca/B blockers and tricyclic antidepressants |
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spontaneous emesis toxicology |
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aspirin, acetaminophen, ibuprofen, pheophylline |
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Forced alkyline diuresis complications |
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PE, alkalemia, hypokalemia,
consider hemodyialsis for cholorohexyphosphate herbicide |
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methylene glycol antidote |
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crotalidae polyvalent immune fab |
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CO poisening signs and symptoms |
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Pinkish --> cherry red skin discoloration
target = brain/heart with delayed neurological problems (3-21 days later)
hyperbaric O2 efficacy still debated |
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H2SO3 formation with mucous contact causes irritation/bronco-constriction/asthma response
Tx = support |
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Nitrogen Oxides toxicology |
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Farm Silage
Pulmonary edema, irritate eyes,nose,throat
Tx = support |
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Definition
Low concentrations: cough, decrease pulmonary compliance
high: pulmonary edema, thickening terminal bronchioles, bronchitis
Tx = support |
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acute arsenic and inorganic mercury poisoning chelator
combo with EDTA for Pb poisening
no reversal neural Hg symptoms not recommended Fe/Cd poisening
AE: tachycardia, HyperT, nausea/vomit, increased prothrombin time |
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Oral dimercaprol chelator used for Pb poisening.
Must monitor Hb/Fe/Liver enzymes
adverse: GI upset, arrhythmia, hepatotoxic, rash |
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Chelator used to treat Pb poisening if blood over 70 add dimercaprol as well
AE: arrythmia, ECG delta, hypoT, CNS (fever and fatique) |
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Fe chelator for acute toxicity
High doses associated with acute respiratory distress, skin flushing, hypotension.
Prolonged = auditory/visual effects and suseptibility to yersinia
ascorbic acid may enhance adverse effects |
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Definition
Released during buring coal, moonshine (from H20 source), pressure treated wood, traditional medicines
Binds to sulfhydral groups to interfere with enzymes, gluconeo, and glutathione
Rice-water stool = buzz word! hypo/hyper pigmented and cancerous skin (check x-ray, skin, liver biopsy)
antidote: dimercaprol |
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Battery manufactor, paints
Inactivates gamma-aminolevulinic acid dehydrase necessary for synthesis of heme and interferes with calcium (bone and nerves)
Acute: abdominal effects, neuro changes, joint pain, nephropathy Chronic: miscarriage
X-ray: BURTON LINE >70 |
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Definition
1. fish and plant water, thimersol vaccine (rare)
2. Interacts sulfhydral groups, inhibits enzymes, and alters cell permiability
Inhale: pneumonitis/P. edema ingest: hemorragic GI issues and renal failure
TRIAD: TREMOR, PSYCHIATRIC, GINGIVOSTOMATOSIS (may constrict visual fields with methylmercury)
CNS and KIDNEY
penicillamine, succimer, DIMERCAPEROL |
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Produces ROS --> Gi pain, acidosis, multisystem organ failure
hepatoxicity and bowel obstruction (from scars)... whole bowel irrigation method of choice |
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Ethanol Methanol Ethylene glycol |
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Ethanol --> acetaldehyde --> Acetic acid Methanol --> formic acid/formaldehyde Glycol --> oxalic acid --> nephrosis
May cause respiratory failure and alcoholic ketoacidosis (MeOH,glycol>ethanol>isopropanol) SWEET BREATH
Methanol in paint causes blindness glycol = kidney stones and profound gap, give bicarb! |
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stimulant in bodybuilding supplement may cause heart attacks |
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