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Toxicology Chapter 6
N/A
4
Chemistry
Undergraduate 4
03/25/2010
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Term
7 Oxidation Reactions Catalyzed by the P450 system
 Definition

Hydroxylation of an aliphatic or aromatic carbon

Epoxidation of a double bond

Heteroatom oxygenation and hydroxylation Heteroatom dealkylation

Oxidative Group Transfer

Cleavage of Esters

Dehydrogenation


Term
Characteristics of P450
 Definition

 

  • Requires NADPH and O2
  • Catalyzes 7 reaction types
  • Occurs in liver and most other tissues
  • Humans express 15 forms
  • Not as heat labile as FMO
  • Sensitive to non-ionic detergent

 
Term
Characteristics of FMO (Flavin Monooxygenase)
 Definition

  • Requires NADPH and O2
  • Catalyzes heteroatom oxidation
  • Occurs in liver, kidney and lung
  • Humans express 6 forms
  • Heat labile at 50C
  • Less detergent sensitive than P450
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