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Toxicity/Antidotes
Drug toxicity antidotes
36
Medical
Graduate
05/19/2010

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Cards

Term
Antidote to salicylates
Definition
Alkalinize urine & dialysis
Term
Antidote to Anticholinesterases
Definition
Atropine, pralidoxime
Term
Antidote to Antimuscarinic, anticholinergic drugs
Definition
Physostigmine, salicylate
Term
Antidote to Beta blockers
Definition

Glucagon

Calcium gluconate

dextrose-insuline therapy

Term
Antidote to Digitalis
Definition
Lidocaine, anti-dig Fab fragments, Mg2+, normalize K+
Term
Antidote to Iron
Definition
Deferoxamine
Term
Antidote to Lead
Definition
CaEDTA, dimercaprol, succimer, penicillamine
Term
Antidote to Arsenic,
Definition
Dimercaprol (BAL), succimer, Penicillamine
Term
Antidote to Copper
Definition
Penicillamine
Term
Antidote to Cyanide
Definition

Amyl Nitrite

hydroxocobalamine

Sodium thiosulfate

Term
Antidote to Methemoglobin
Definition
Methylene blue
Term
Antidote to Methanol
Definition
Ethanol, fomepizole, dialysis
Term
Antidote to Benzodiazepines
Definition
Flumazenil
Term
Antidote to TCAs
Definition

NaHCO3 (serum alkalinization)

Benzos

Term
Antidote to Heparin
Definition
Protamine Sulfate
Term
Antidote to Warfarin
Definition
Vitamin K, FFP
Term
Antidote to tPA
Definition
Aminocaproic acid
Term
Antidote to acetominophen
Definition
N-acetylcysteine
Term
Antidote to Amphetamines
Definition
NH4Cl to Acidify Urine
Term
Antidote to organophosphates
Definition
Atropine, pralidoxime
Term
Antidote to Mercury
Definition
Dimercaprol (BAL), succimer
Term
Antidote to Gold
Definition
Dimercaprol (BAL), succimer, Penicillamine
Term
Antidote to ethylene glycol (antifreeze)
Definition
Ethanol, fomepizole, dialysis
Term
Antidote to streptokinase
Definition
Aminocaproic acid
Term
Antidote to Carbon Monoxide
Definition
Ethanol, dialysis, fomepizole
Term
Antidote to opiodes
Definition
Naloxone/naltrexone
Term
Antidote to Theophylline
Definition

Beta-blocker

Benzos

Term
Antidote to Isoniazid (INH)
Definition
Pyridoxine (Vitamin B6)
Term
Quinidine
Definition

Hypertonic Sodium Bicarb

lidocaine

magnesium sulfate

Term
Antidote to Strychnine
Definition

Benzos

neuromuscular blockade

Term
Sxs of Organophosphate Poisoning
Definition
Peripheral Nicotinic and Muscarinic stimulation, seizures and CNS depression.
Muscarinic Stimulation causes
D- diarrhea, diaphoresis
U- Urination
M- Miosis
B- Bronchospasm, Bronchorrhea, Bradycardia
E- Emesis
L- Lacrimation
S- Salivation
Term
Local Anesthetic systemic toxicity
Definition
1. Oxygen
2. hyperventilate
3. Intralipid 20% IV
Term
Reverses EPS side effects of Chlorpromazine
Definition
Diphenhydramine
Term
Cisplatin
Definition
Toxicity: Nephrotoxicity
Protective measure: amifostine (free-radical scavenger)
Term
Methotrexate
Definition
Toxicity: Myelosuppression
Anti-dote: leukovorin (folinic acid) rescue
Term
Doxorubicin
Definition
Toxicity: cardiotoxicity
Prevention: dexrazoxane (Fe chelating agent)
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