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Topic 5`
Episodic vs Semantic Memory - The Role of the Hippocampus
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Undergraduate 4
01/30/2017

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Term
Are both episodic & semantic memory systems large, complex, highly structured, and can hold practically unlimited amounts of information?
Definition
yes!
Term
Do episodic & semantic memory systems receive information from sensory modalities, internally generated sources, neither, or both?
Definition
both
Term
Is the process for encoding information into long-term storage similar or quite different for episodic & semantic memory?
Definition
similar
Term
which memory deals with events?
Definition
episodic
Term
which memory deals with facts?
Definition
semantic
Term
What does it mean that stored information in both systems is "representational"?
Definition
the information is functionally isomorphic with what is or could be in the world
Term
What does it mean that stored information in both systems is "propositional"?
Definition
an intelligent observer can describe it & its expression symbolically
Term
What does it mean that information in both systems has truth value?
Definition
it either matches or does not match with the state of affairs in some other system, such as the outside world
Term
What does it mean that information in both systems is accessible & can be expressed flexibly?
Definition
accessible through a wide variety of retrieval queries & routes; expressed through a wide variety of signs or behaviors
Term
What does it mean that processing of information is highly sensitive to context?
Definition
elements of our physical surroundings become embedded in our learning of new information
Term
Are both systems "cognitive" or "behavioral"?
Definition
cognitive (products of retrieval can be consciously contemplated or thought about)
Term
Is behavioral expression of products in retrieval in both systems optional or obligatory?
Definition
optional
Term
Do episodic & semantic memories serve the same function?
Definition
no!
Term
_____ memory is the only memory that, at the time of retrieval, is oriented towards the past
Definition
episodic
Term
Episodic memory is accompanied by _____ conscious awareness
Definition
autonoetic
Term
autonoetic consciousness
Definition
"self knowing" & self awareness
Term
Through _____ memory we are aware of our own identity & existence in subjective time that extends from the past through the present into the future
Definition
episodic
Term
What does it mean that the relationship between remembering & knowing is one of embeddedness?
Definition
episodic remembering always implies semantic knowing, whereas knowing does not imply remembering
Term
Which memory lags behind the other in terms of human development?
Definition
episodic lags behind semantic
Term
Is episodic or semantic memory more vulnerable to pathologies of the brain?
Definition
episodic
Term
Is episodic or semantic memory a more recent arrival on the evolutionary scene?
Definition
episodic
Term
Does episodic or semantic memory rely more on the frontal lobes?
Definition
episodic
Term
2 meanings for the term conscious recollection
Definition
1. intentional in the sense that you actively initiated a search of your memory
2. an awareness of remembering - a sense that a memory trace has been successfully activated
Term
3 places the entorhinal cortex projects to
Definition
1. dentate gyrus
2. CA3
3. CA1
Term
What types of cells are found in CA3?
Definition
pyramidal cells
Term
Are interneurons usually glutamatergic or GABAergic?
Definition
GABAergic
Term
2 inputs required for pattern separation
Definition
1. relatively weak but diffuse direct perforant path to CA3
2. strong but sparse mossy fibers
Term
"pattern separation"
Definition
representing cortical activity & minimizing overlap of cortical representations
Term
"pattern completion"
Definition
modifying synaptic connections so cortical representations can later be recalled from partial or noisy version of these representations
Term
two inputs required for pattern separation
Definition
1. "relatively weak but diffuse direct perforant path to CA3"
2. "strong but sparse mossy fibers"
Term
Does neurogenesis occur in the dentate gyrus?
Definition
yes!
Term
What is the name given to new cells generated in the dentate gyrus?
Definition
new adult-born dentate gyrus granule cells (young DGCs)
Term
The functional integration of adult-born (young) DGCs into the mnemonic function of area CA3 in _____
Definition
pattern separation
Term
What is the role of the relatively weak but diffuse path to the CA3?
Definition
to convey the memory representations from the EC
Term
Strong but sparse mossy fiber synapses come onto CA3 PCs from _____
Definition
young DGCs
Term
What is the major difference in function of mature DGCs & young DGCs?
Definition
mature = optimally set up to respond to past experiences

young = the capability to encode new/unforeseen events
Term
What is the role of the perforant path to the CA3 in pattern completion & recall?
Definition
to activate already established representations stored via the recurrent collaterals of CA3 pyramidal cells
Term
For pattern completion & recall, strong but sparse mossy fibers synapse onto the CA3 PCs from _____
Definition
"mature" DGCs
Term
pattern completion
Definition
a subset of the original experience can activate the memory for the entire experience; does NOT requires mossy fiber activation
Term
Why is the associative connectivity in the cortex not sufficient to store memories?
Definition
too low to support the rapid changes needed to associate patterns of activation distributed widely across the neocortex
Term
What is the benefit of the associative connectivity in the hippocampus?
Definition
it is rich & connections are easily modified
Term
What is tested for in the explicit memory test?
Definition
intentional retrieval & conscious recollection of information
Term
What is tested for in the implicit memory test?
Definition
unintentional, unconscious retrieval of previously acquired information
Term
Do amnesic people display incidental learning?
Definition
no!
Term
Acquisition of context memories depends on the _____
Definition
hippocampus
Term
What was being studied with Beth, Jon, & Kate?
Definition
what happens when the hippocampus is damaged early in life
Term
Beth, Jon, & Kate had very impaired _____ memory but had normal language & social skills
Definition
episodic
Term
Were Beth, Jon, & Kate able to read & write & acquire new factual information?
Definition
yes!
Term
Were Beth, Jon, & Kate able to recall stories from logical memory after a 90 minute waiting period?
Definition
no!
Term
Were Beth, Jon, & Kate able to reproduce a geometric design after a 40 minute waiting period?
Definition
no!
Term
Were Beth, Jon, & Kate able to recall scores for two 16 word lists immediately after they were presented?
Definition
yes!
Term
Can episodic memory be considered separate from semantic memory (based off of Beth, Jon, & Kate)?
Definition
yes!
Term
Why is the view that episodic memory is separate from semantic memory controversial?
Definition
damage to the hippocampal region in adults equally impairs both semantic & episodic memory
Term
Do universalists view the function of various medial structures as absolute?
Definition
no!
Term
"schemas"
Definition
preexisting knowledge structures into which newly acquired information can be incorporated
Term
Has the schema concept been shown to be relevant in rats for the phenomenon of memory consolidation?
Definition
yes!
Term
memory consolidation
Definition
the gradual process of reorganization by which new memories become remote memories
Term
As time passes after learning, the importance of _____ gradually diminishes & a more permanent memory is established in distributed regions of the _____
Definition
hippocampus; neocortex
Term
How long does the consolidation process from hippocampus to neocortex take in humans? In rats?
Definition
humans = a few years

rats = a few months
Term
Describe Tse's flavor memory experiment
Definition
animals learned the six flavor-place associations gradually across 6 weeks of training; each flavor-place pair was presented once per session for training & three sessions were scheduled each week
Term
Were rats with hippocampal lesions able to learn Tse's flavor-place associations?
Definition
no!
Term
How did Tse's flavor-place experiment support the existence of schemas?
Definition
animals were subsequently able to learn new flavor-place associations in a single trial & could remember the new associations for at least 2 weeks
Term
What was the most surprising finding by Tse that connected the schema concept to memory consolidation?
Definition
removal of the entire hippocampus as early as 48 hours after the rapid learning of two new flavor-place associations fully spared memory of the associations (these animals had first been given extensive training on six other flavor-place associations, thus establishing a schema)
Term
What was the result of Tse lesioning the hippocampus 3 hours after learning?
Definition
abolished the memory of new associations
Term
Was Tse's memory consolidation unusually fast in his animals?
Definition
yes!
Term
3 cortical regions that research is finding to be increasingly important as time passes after learning
Definition
1. prefrontal cortex
2. temporal cortex
3. anterior cingulate cortex
Term
Is it thought that memory literally passes from the hippocampus to the neocortex?
Definition
no! (the hippocampus guides gradual changes in the neocortex that increases the complexity, distribution, & interconnectivity of memory storage sites)
Term
two forms of declarative memory
Definition
1. episodic
2. semantic
Term
Hippocampal area _____ is important for the formation of distinct episodic events
Definition
CA3
Term
The direct perforant path (weak & diffuse), & which brings the memory representations to area CA3 during storage is also necessary for _____
Definition
pattern completion (recall of the memory event)
Term
2 places where episodic memories can be stored
Definition
1. hippocampus (as a result of short term consolidation)
2. neocortex (as a result of long-term consolidation)
Term
intentional memory
Definition
study conditions in which participants are forewarned that they will be tested on the material to which they are exposed
Term
unitary view of semantic memories
Definition
semantic memories could become hippocampal INDEPENDENT after long term consolidation (gradual process of reorganization by which new memories become remote memories) and, thus, they do NOT require hippocampal indexation for recall
Term
separatist view of semantic memories (supported by Vargha-Khadem findings)
Definition
semantic memories do not require the hippocampal formation
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