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Topic 13
Eucaryotic cell division (Mitosis)
33
Biology
Undergraduate 1
04/14/2012

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Term
Daughter cells
Definition
Two cells that result from mitosis.
Term
Cell Cycle
Definition
Regulated series of events in mitosis.
Term
Interphase
Definition
Phase between divisions.
Term
G1 Phase
Definition
Preparation for DNA replication. Growth period.
Term
S Phase
Definition
Replicate DNA.
Term
G2 Phase
Definition
Final Preparation for cell division. Further growth.
Term
M Phase
Definition
Mitosis and cytokinesis (1 cell becoming 2) occur. Shortest phase.
Term
Checkpoints
Definition
Confirms that everything is in order for the cell to go into the next phase. Most of the cells in the human body are at the G1 checkpoint (G0 Phase).
Term
Cyclins
Definition
Different sets of proteins that are produced during each phase. Cyclins combine with cyclin-dependant kinase (Cdk) to form a Maturation Promoting Factor (MPF). MPF's trigger next phase.
Term
Growth Factors
Definition
External chemical stimuli that stimulate cell to move out of G0 phase.
Term
PDGF (Platelet Derived Growth Factor)
Definition
Stimulates fibroblast division at sites of damage.
Term
EPO (Erythropoietin)
Definition
Growth factor that stimulates production of red blood cells. Banned in many sports.
Term
Division Inhibitions
Definition
Anchorage dependance: Cells need to be anchored on something to divide.
Density-dependent inhibition: Cell's will not divide unless there is room.
Term
Transformed
Definition
State of cancerous cells (uncontrolled growth).
Term
Mutagens
Definition
Chemicals that cause mutations in the cell cycle regulation genes.
Term
Benign
Definition
Tumors which remain localized, grow slowly and are easily treated.
Term
Malignant
Definition
Tumors which grow fast, are invasive, and can spread by metastasis. Difficult to treat.
Term
Metastasis
Definition
Cancer cells spreading.
Term
Chromosomes
Definition
Are composed of chromatin.
Term
Chromatin
Definition
Combination of DNA and protein.
Term
Sister Chromatids
Definition
Pair of chromosomes.
Term
Centromere
Definition
Point at which chromatids are attached.
Term
Diploid
Definition
Possessing two of each chromosome (one paternal, one maternal).
Term
Homologous Chromosomes
Definition
Have different alleles of the same genes.
Term
Heterologous Chromosomes
Definition
Pair of chromosomes that have different genes (X and Y in males).
Term
Autosomes
Definition
Chromosome pairs 1-22.
Term
Mitosis - Prophase
Definition
Chromosomes condense, spindle forms, nuclear envelop breaks down.
Term
Centrioles
Definition
Construct spindle and originate in the centrosome.
Term
Mitosis - Metaphase
Definition
Pair of sister chromatids line up at equator of spindle and attach to spindle fibers.
Term
Kinetochore
Definition
Point on sister chromatids were spindle attaches.
Term
Mitosis - Anaphase
Definition
Spindle elongates and fibers shorten, sister chromatids are separated (dynein pull chromosomes down microtubule).
Term
Mitosis - Telophase and Cytokinesis
Definition
New nuclear envelopes form around each group of chromosomes, cytoplasm divides to two cells.
Term
Cytokinesis
Definition
In animal cells, cleavage furrow forms and cell "pinches" in half.
In plant cells, vesicles containing cell wall material form a new cell wall in between the 2 nuclei.
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