BRAND/GENERIC: Combivent

CLASS: Anticholindergic/Selective B2-Agonist Combo INDICATION: COPD

MOA: Albuterol is selective B2-adrenergic agonist producing bronchodilation, vasodilation, uterine relaxation, skeletal muscle stim, peripheral vasodilation, tachycardia. Ipratopium - competitive antag of ach at peripheral but not central muscarinic receptor. Appears to produce bronchodilation by inhib of cholinergic receptors on bronchial smooth muscle.

DOSAGE FORM: Metered dose inhaler, inhalation solution

BRAND/GENERIC: Spiriva

CLASS: Anticholinergic bromchodilator

INDICATION: COPD

MOA: Long acting antimuscarinic often refered to as anticholinergic. Similar affinity to subtypes of muscarinic receptors M1 to M5. In airways, exhibits pharmacological effects through inhib of M3 receptors at smooth muscle leading to bronchodilation. Bronchodilation following inhalation is mostly site-specific

DOSAGE FORM: Inhalation capsule

BRAND/GENERIC: Tessalon Perles

CLASS: Antitussive

INDICATION: Cough

MOA: Anesthetizing stretch receptors located in the resp passages, lungs, pleura by dampening their activity and thereby reducing cough reflex at source

DOSAGE FORM: Liquid filled capsule

BRAND/GENERIC: Antituss
CLASS: Antitussive, Opioid/Antihistamine Combo product - Sched V

INDICATION: Cough due to allergy, upper resp tract infection

MOA: Codeine is 3-methoxymorphine, phenanthrene opioid with very low affinity for opioid receptors. Works as antitussive through supression of cough reflex by directly affecting cough center in the medulla. Prometh-Phenothiazine derivative competitively blocks antihistamine H receptors w/o blocking histamine secretion. Sedative, antimotion-sickess, antiemetic, anticholinergic. No dopaminergic action

DOSAGE FORM: Oral syrup

BRAND/GENERIC: Tussionex

CLASS: Antitussive, Opioid/Antihistamine combo product - Sched 3

INDICATION: Cough due to minor throat/bronchial indication

MOA: Hydrocodone unknown. Opioid analgesic, antitussive through supression of cough reflex by directly affecting cough center in medulla.

DOSAGE FORM: Oral syrup

BRAND/GENERIC: Cheratussin AC

CLASS: Antitussive, Opioid/Expectorant combo-Sched V INDICATION: Cough due to minor throat/bronchial irritation

MOA: Codeine is 3-methoxymorphine, phenanthrene opiod w/ low affinity to opiod receptor. Antitussive, suppresion of cough reflex, affecting cough center of medulla. Guaifenesin thinning bronchial secretions & increasing sputum volume. Promotes lower respiratory track drainage and removal of mucus

DOSAGE FORM: Oral syrup

BRAND/GENERIC: Proventil

CLASS: Selective B2 agonist

INDICATION: Asthma - acute exacerbation and bronchospasm

MOA: Selective B-adrenergic agonist producing bronchodilation, vasodilation, uterine relaxation, skeletal muscle stim, peripheral vasodilation, tachycardia

DOSAGE FORM: Inhalation solution

BRAND/GENERIC: ProAir HFA

CLASS: Selective β₂-agonist

INDICATION: Asthma-acute exacerbation/bronchospasm/exercise induced

MOA: Selective β₂-adrenergic agonist producing bronchodilation, vasodilation, uterine relaxation, skeletal muscle stim, peripheral vasodilation, tachycardia

DOSAGE FORM: Metered dose inhaler, Tab, Extended release Tab

BRAND/GENERIC:Xopenex

CLASS: Selective β₂ ag, Bronchodilator

INDICATION: Asthma-acute exacerbation/bronchospasm MOA: Activation of β₂-adrenergic receptors on airway smooth muscles leads to activation of adenylate cyclase and cyclic AMP. Increase in protien kinase A, inhibits phosphorylation of myosin & lowers intracell levels of Ca, resulting muscle relaxation

DOSAGE FORM: Metered dose inhaler

BRAND/GENERIC: Advair Diskus

CLASS: Inhaled corticosteroid, Long-Acting B2-adrenergic agonist combo

INDICATION: Asthma, COPD

MOA: Futicasone, synthetic trifluorinated corticosteroid with anti-inflammatory effects.A glucocorticoid receptor agonist that inhibits multiple cell types and mediarotr production or secretion in asthma & COPD. Salmeterol is a long acting β₂-adrenergic agonist. Stimulates intracellular adenyl cyclase for making ATP to cyclic AMP. Increased cyclic AMP levels result in relaxation of bronchial smooth muscle and inhibits release of mediators of instantaneous hypersensitivity form mast cells.

DOSAGE FORM: Inhalation disk, Metered dose inhaler

BRAND/GENERIC: Pulmicort respules/Flexhaler

CLASS: Inhaled corticosteroid

INDICATION: Asthma

MOA: Anti-inflammatory w/potent gluticocorticosteroid, weak mineralcorticoid activity. Broad range of active inhib against multiple cell types involving allergic and nonalergic irritant mediated inflammation

DOSAGE FORM: Inhalation suspension, Metered dose inhaler

BRAND/GENERIC: Symbicort

CLASS: Inhaled corticosteroid/bronchodilator combo INDICATION: Asthma, COPD

MOA: Budesonide is anti-inflamatory w/ potent glucocorticoid and weak mineralocorticoid activity. Broad range of active inhibition against multiple cell types and mediators involving allergic & nonallergic/irritant mediated inflamation. Formoterol is a long-acting selective β₂-adrenergic agonist that produces bronchodilation

DOSAGE FORM: Metered dose inhaler