Shared Flashcard Set

Details

Top 200 (61-70)
IPPE (Miles) Info from book
10
Pharmacology
Professional
11/12/2011

Additional Pharmacology Flashcards

 


 

Cards

Term

 

 

 

 

Temazepam

Definition

Restoril®

 

Uses: *Insomnia*, anxiety, depression, panic attacks

 

MOA: Benzodiazepine

 

Dose: 15-30 mg po HS PRN, ↓ in elderly

 

Caution: X, ?/-, Potentiates CNS depressive effects of opioids, barbs, EtOH, antihistamines, MAOIs, TCAs

 

CI: NAG

 

Disp: Caps 7.5, 15, 22.5, 30 mg

 

SE: Confusion, dizziness, drowsiness, hangover

 

Notes: Abrupt DC after >10 days use may cause withdrawal

 

Schedule: C-IV

Term

 

 

 

 

Promethazine

Definition

Phenergan®

 

BBW: Do not use in pts <2 yrs; resp depression risk; tissue damage, including gangrene w/ extravasation

 

Uses: *N/V, motion sickness, adjunct to post op analgesics, sedation, rhinitis*

 

MOA: Phenothiazine, blocks CNS postsynaptic mesolimbic dopaminergic receptors

 

Dose: Adults: 12.5-50 mg PO, PR, or IM BID-QID PRN Peds >2: 0.1-0.5 mg/kg/dose PO/IM q2-6h PRN

 

Caution: C, +/-, Use w/ agents w/ resp depressant effects

 

CI: Component allergy, NAG, age <2 yrs

 

Disp: Tabs 12.5, 25, 50 mg; Syrup 6.25 mg/5 mL, 25 mg/5 mL; Supp 12.5, 25, 50 mg; Inj., 25, 50 mg/mL

 

SE: Drowsiness, tardive dyskinesia, EPS, lowered Sz threshold, ↓ BP, GI upset, blood dyscrasias, photosens, resp depression in children

 

Notes: IM/PO preferred route, not SQ or intra-arterial

Term

 

 

 

 

Glimepiride

Definition

Amaryl®

 

Uses: *Type 2 DM*

 

MOA: Sulfonylurea, ↑ pancreatic insulin release; ↑ peripheral insulin sensitivity; ↓ hepatic glucose output/production

 

Dose: 1-4 mg/d, max 8 mg

 

Caution: C, -

 

CI: DKA

 

Disp: Tabs 1, 2, 4 mg

 

SE: HA, N, hypoglycemia

 

Notes: Give w/ 1st meal of day

Term

 

 

 

 

Albuterol nebulizing soln

Definition

Ventolin®

 

Uses: *Asthma, COPD, prevent exercise-induced bronchospasm*

 

MOA: Beta adrenergic sympathomymetic bronchodilator; relaxes bronchial smooth muscle

 

Dose: Adults: 1.25-5 mg (0.25-1 mL of 0.5% soln in 2-3 mL of NS) TID-QID. Peds: 0.05 mg/kg (max 2.5 mg) in 2-3 mL of NS TID-QID. 2-6 yr: 12 mg/d, 6-12 yr: 24 mg/d

 

Caution: C, +

 

Disp: 0.083%, 0.5%

 

SE: Palpitations, tachycardia, nervousness, GI upset

Term

 

 

 

 

Tamsulosin HCl

Definition

Flomax®

 

Uses: *BPH*

 

MOA: Antagonist of prostatic alpha receptors

 

Dose: 0.4 mg/d, may ↑ to 0.8 mg/d

 

Caution: B, ?

 

CI: Female gender

 

Disp: Caps 0.4 mg

 

SE: HA, dizziness, syncope, somnolence, ↓ libido, GI upset, retrograde ejaculation, rhinitis, rash, angioedema, IFIS

 

Notes: Not for use as antihypertensive; do not open/crush/chew; approved for use/ dutasteride for BPH

Term

 

 

 

 

Folic Acid

Definition

No Brand Name

 

Uses: *Megaloblastic anemia; folate deficiency*

 

MOA: Dietary supl

 

Dose: Adults: Supl: 0.4 mg/d PO; PRG: 0.8 mg/d PO. Folate Def: 1 mg PO daily-TID. Peds: Supl: 0.04-0.4 mg/24 hr PO/IM/IV/SQ

 

Caution: A, +

 

CI: Pernicious, apastic, normocytic anemias

 

Disp: Tabs, 0.4, 0.8, 1 mg; Inj 5 mg/mL

 

SE: Well tolerated

 

Notes: OK for all women of child-bearing age, ↓ fetal neural tube defects by 50%, no effect on normocytic anemias 

Term

 

 

 

 

Spironolactone

Definition

Aldactone®

 

BBW: Tumorogenic in animal studies, avoid unneccesary use

 

Uses: *Hyperaldosteronism, HTN, Class III/IV CHF, ascites from cirrhosis*

 

MOA: Aldosterone antagonist; K+ sparing diuretic

 

Dose: Adults: CHF (NYHA class III-IV): 12.5-25 mg/d (w/ ACE and loop diuretic); HTN: 25-50 mg/d; Ascites: 100-400 mg QAM w/ 40-160 mg of furosemide, start w/ 100 mg/40 mg, wait at least 3 d before ↑ dose. Peds: 1-3.3 mg/kg/24 h PO ÷ BID-QID. Neonates: 0.5-1 mg/kg/dose q8h; take w/ food

 

Caution: D, +

 

CI: ↑ K+, acute renal failure, anuria

 

Disp: Tabs, 25, 50, 100 mg

 

SE: ↑ K+ & gynecomastia, arrhythmia, sexual dysfunction, confusion, dizziness, D/N/V, abnormal menstruation

Term

 

 

 

 

Amlodipine besylate & Benazepril

Definition

Lotrel®

 

BBW: Fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; DC drug as soon as possibly once pregnancy detected

 

Uses: *HTN*

 

MOA: Dihydropyridine calcium channel blocker, ACE inhibitor

 

Caution: D, ?, Renal artery stenosis, renal impairment, hepatic impairment, volume depletion, hyponatremia, hypotension, elderly, CHF, aortic stenosis, severe CAD

 

CI: Hypersensitivity, history of angioedema, pregnancy

 

Disp: Caps, 2.5/10, 5/10, 5/20, 5/40, 10/20, 10/40 mg

 

SE: Cough, HA, edema, dizziness, flushing, fatigue, somnolence, elevated BUN, Cr

Term

 

 

 

 

Amphetamine salt combo

Definition

Adderall®

 

BBW: High abuse potential, dependency

 

Uses: *ADHD, Narcolepsy*

 

MOA: Stimulates CNS activity; blocks reuptake and increases release of norepinephrine and dopamine in extraneuronal space

 

Dose: ADHD: 5-40 mg/day divided QD-TID. Narcolepsy: 5-60 mg divided QD-TID

 

Caution: C, -,elderly, psychosis, bipolar disorder, history of seizures

 

CI: Hypersensitivity, cardiovascular disease, arrhythmias, HTN, glucoma, drug abuse history

 

Disp: Tabs, 5, 7.5, 10, 12.5, 15, 20, 30

 

SE: Anorexia, insomnia, abdominal pain, HA, emotional lability, weight loss, nervousness, dry mouth, N/V, asthenia, D, dyspepsia, dizziness, palpitations, elevated BP, tachycardia, tremor, dyskinesia, constipation, libido changes, impotence, visual disturbances, tics 

Term

 

 

 

Metformin HCl ER

Definition

Glucophage® XR

 

BBW: Associated w/ lactic acidosis

 

Uses: *Type 2 DM*, polycystic ovary synd (PCOS), HIV lipodystrophy

 

MOA: Biguanide, ↓ hepatic glucose production & intestinal absorption of glucose; ↑ insulin sensitivity

 

Dose: Adults: Initial: 500 mg PO BID, or 850 mg daily, titrate 1-2 wk intervals may ↑ to 2550 mg/d max; take w/ AM & PM meals; XR dose is total daily dose of IR. Peds 10-16 yrs: Do not use XR

 

Caution: B, +/-, Avoid EtOH; hold dose before & 48 hrs after ionic imaging contrast; hepatic impair, elderly

 

CI: SCr> 1.4 mg/dL in females or >1.5 mg/dL in males; hypoxemic conditions (e.g acute CHF/sepsis); metabolic acidosis

 

Disp: Tabs, 500, 850, 1000 mg; XR tabs, 500, 750, 1000 mg; Soln, 100 mg/mL

 

SE: Anorexia, N/V/D, flatulence, weakness, myalgia, rash

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