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Pen VK cidal: inhibits cell wall synthesis *COCs have reduced effectiveness because enterohepatic recycling is inhibited |
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Amoxil cidal: inhibits cell wall synthesis *COCs have reduced effectiveness because enterohepatic recycling is inhibited |
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Augmentin cidal: inhibits cell wall synthesis *and beta lactamases |
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Keflex cidal: inhibits cell wall synthesis *UTI indication *10% of pt with PCN allergy are cross-reactive |
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Omnicef cidal: inhibits cell wall synthesis *UTI indication *10% of pts with PCN allergy have cross-reactivity *antacids will decrease absorption |
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Levaquin cidal: inhibits topoisomerase *UTI indication ~tendonitis/rupture |
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Cipro cidal: inhibits topoisomerase *UTI indication ~tendonitis |
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Avelox cidal: inhibit topoisomerase ~tendonitis |
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Zithromax static: binds to 50S *CAP dosing: 500mg PO day 1, then 250mg PO days 2-5 or 500mg IV x 2 days then 500mg PO to complete 7-10 days |
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( ) static: inhibits protein synthesis *malaria prophylaxis *off-label use for rosacea *photosensitivity |
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sulfamethoxazole/trimethoprim** |
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Bactrim static: inhibits folate synthesis and PABA utilization *adequate fluid intake to prevent kidney stones *photosensitivity |
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Valtrex inhibits DNA polymerase |
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Zovirax inhibits DNA polymerase |
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Tamiflu inhibits DNA polymerase *75mg PO BID x 5 days within 48 hours of symptoms |
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Diflucan inhibits sterol demethylation |
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Micronase stimulates beta cell insulin release |
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Glucotrol ER stimulates beta cell insulin release |
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Glucophage increases insulin sensitivity, decreases gluconeogenesis *also for PCOS! ~risk of lactic acidosis in renal impairment |
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Avandia increases insulin sensitivity via PPAR gamma ~may exacerbate CHF and increase risk of MI |
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Actos increases insulin sensitivity via PPAR gamma activation ~may exacerbate CHF |
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