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tobacco depepndance treatmetnq
tobacco
43
Medical
Graduate
10/23/2011

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Term
smoking going down in all tehnic gorups ,thoug htarget has not been rached
Definition
Term
tshoe growign tobacco have grater usage and those with antitobacoc programs ahve less usage
Definition
Term
cigar use has increased. chewing tobacco used mroe by men
Definition
Term
highest cause of death in women
Definition
lung cancer.
Term
most frequent smokers
Definition
living below porvery line. Those with comorbid metnal rpoblems/substance abuse problems- they die earlier due to this.
Term
most smokers start before 18 (usually grades 6-9)
Definition
pediatric smoekrs arem olikely to become dpepndant
Term
african americans like mentho lcigarettes
Definition
these are correlated with higher nictoine levels
Term
ncitone pharmaoclogy
Definition
highly and quickly abosrbed by cns, short half life so dissappears quickly - key fto its addictvity.
Term
nictoine safety
Definition
is nto a carcinogen, is not a significant risk factor for cardio disease .
Term
nicotine withdrawal
Definition
dysphoria ,insoaminia ,irritability, anxiety, restlessness difficulty , decreased heart rate , icnreaed apetetie and weight gain- fiarly nonspecific signs
Term
heaviness of smokign index
Definition
measure of deependance. Numbero f cigarrets per day. Time to first cigarettte (less tha n30 minutes is modreate, less tha nfivem inutes is severe
Term
very hard to quit
Definition
especially without treatment, with elss than five percent ulitimately succesful in a given quit attempt.
Term
logner physician advice sessions i s correlated with higher percentage of quitting
Definition
Term
pharm treatmetn of nictoine dpeepndanece rationale
Definition
reduce or elimiante withdrawal, combat reinforcin g effects of nictoine negative mood state releiving, and therefore unlearn smoking
Term
nictoine gu mvs. cigarrete distributino
Definition
efficient and high delivery of nictoine- gets into bloodstream and brain fast-spike. nictoien gum-gradually itn obloodstream. NNS- the nasal spray- spike lvel is itnermediate between that of the gum and cigarretes. Cigarretes stil lahve the largest spike.
Term
nictoien replacemetn therapy features
Definition
poorer absorption than cigs , lower dose delivered, undersoign is common. poor oral absorption, significant first pass effect.
Term
CONTRAINDICATIONS TO NRT
Definition
very few of them- recent MI, smoking less than 10cpd, if pregnant ro breastfeeding, and adolescents.
side effects are mostly local
Term
nictoine patch features
Definition
slow onset with contioues delivery.
Term
nictone patch side effects
Definition
insomnia, skin reaction
Term
nictoine gum pharmacokinetics
Definition
buccally absorbed (need tobite and park). Acidic food decreases absorb.
Term
side effects o nicotine patch
Definition
mouth, throat burning
Term
nicotine lozenge dosage
Definition
based on ttfc
Term
nictoine inhaler
Definition
misnomer- is actually oral puffer. acidic beverages decrease bsorption, prescriptino needed
Term
nictoien ihaler side effects
Definition
throat irritation or coughing
Term
nicotine nasal spray
Definition
moer rapid delivery than oral mucosa however has the msot side effects!! SOme dpeepdnace libailty, Rx needed
Term
nicotine nasal spray
Definition
moer rapid delivery than oral mucosa however has the msot side effects!! SOme dpeepdnace libailty, Rx needed
Term
nicotine nasal spray side e ffects
Definition
ENT side effects
Term
bupropion SR usage and effects
Definition
antidepressant, with effects on NE and DA.
Term
bupropion moa
Definition
noncompetitiven ictonic receptor antagonist , has to be started 10-14 days prior to quit date
Term
buprion advantage
Definition
has least weight gain of al ltreatment methods
Term
bupriopin side effects
Definition
headaches , insomina, contraindicated with seizures
Term
eficay of nrt treatmetns
Definition
overall have an odds ratio of almsot 2 for treatment efficacy
Term
varenicline features
Definition
a4b2 nictoinic parital agonist . works better tha bupropion.
Term
varenciline side effects
Definition
nausea,headache insomnia and abnormal dreams
Term
nicotine bidning sites
Definition
predominantely ACH receptors in cns, - particualry inventral tegmental ara which sends dopamien relase signals to nucleus acucmbens ,which is bleived to be linekd to reward
Term
varenciline advantages
Definition
blcoks the site when ncitoien is added, . when nicotien is added we still havethe aprtial agonsit curve. however withdrawal effects dont occur
Term
veranicline advantageous proeries
Definition
no fodo effect on pharockinetics, halflife of 24 hours, excreted unchanged through kidney so no significant drug drug itneractions . and low plasma protein bidning.
Term
somking correlations
Definition
predictor of suicidal thoughts and icnreased completion, increased incidenceo f mental illnesses
Term
psychocoial traetments
Definition
betwest when combiend with emdications- dose responserelationship- more time spent = greater success.
Term
psychocoial traetments
Definition
betwest when combiend with emdications- dose responserelationship- more time spent = greater success.
Term
psychocoial traetments
Definition
betwest when combiend with emdications- dose responserelationship- more time spent = greater success.
Term
quitline
Definition
avilable, statefunded, works well
Term
lack of evidence basis for quitting
Definition
acupuncture, excercise hynposis
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