Term
|
Definition
-Agent inactivated and removed
-Debride nonviable material
-Provide Building framework (angiogenesis, migration of cells, proliferation)
-Regenerate of repair |
|
|
Term
|
Definition
| scars form in tissues that cannot regenerate made up of fibrous tissue and lots of new capillaries |
|
|
Term
| Wound healing: First Intention |
|
Definition
Neutrophils: 24 hrs
Macrophages: 3 days
Granulation tissue: 5 days
Mature collagen: 10 days
Scar: 1 month |
|
|
Term
| Wound healing: Second Intention |
|
Definition
| large tissue defect (granulation and huge scar) |
|
|
Term
| Wound healing: Second Intention |
|
Definition
| large tissue defect (granulation and huge scar) |
|
|
Term
| Epidermis, Dermis, Subcutis (Fat) |
|
Definition
-Wound penetrated epidermis & dermis, later fibrin forms blood clot
-Epidermis grows over granulation tissue, underneath blood clot
-Myofibroblasts contract and close the wound, leave white scar |
|
|
Term
| Continuously dividing cells (labile) |
|
Definition
stem cells replicate and replace terminally differentiated (mature) cells
Ex, bone marrow, epithelial cells of Intestinal tract, stem cells |
|
|
Term
|
Definition
Liver and the kidney, have capacity to regenerate as long as there is a small piece left
-some stem cells |
|
|
Term
| Terminally Differentiated (permanent) |
|
Definition
once dead stay dead
can only have injury - heal by scarring
ex. myocardium, neurons of brain |
|
|
Term
| EGF (epidermal growth factor) |
|
Definition
| Urine and Saliva -- epithelium |
|
|
Term
|
Definition
| very important for healing in the blood |
|
|
Term
|
Definition
Epidermal Growth factor (EGF)
Platelet derived GF
Vascular endothelial GF, Fibroblast GF
Transforming GF
IL1 and TNF |
|
|
Term
| Modulating Healing: systemic |
|
Definition
Age +/-
Malnutrition (vitamin C, zinc, AA)
Haematological abnormalities (neutropenia, haemophilia)
Diabetes (WBC, Endothelium)
Corticosteroids
Chemotherapy |
|
|
Term
| Modulating Healing: Local Factors |
|
Definition
blood supply
Infection
Foreign bodies
-stimulates inflammation, results in chronic inflammation |
|
|
