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TIM
Hematology
64
Health Care
Graduate
09/29/2007

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Term
Normal PT range
Definition
11-15
Term
Normal aPTT
Definition
20-35
Term
Normal platelet count
Definition
190,000-405,000
Term
In what disease can treatment with prednisone mask leukemia?
Definition
ITP
Term
What happens to PT and PTT with hemophilias?
Definition
PTT prolonged

PT is normal
Term
What are Heinz bodies associated with?
Definition
G6PD deficiency
Term
Which leukemia characteristically shows a high WBC count?
Definition
CML
Term
What is philadelphia chromosome associated with?
Definition
CML
Term
What are Reed-Sternberg cells associated with?
Definition
Hodgkins lymphoma
Term
What findings are commonly associated with myelofibrosis?
Definition
teardrop poilkiocytosis, nucleated RBC, giant platelets
Term
What is poikilocytosis?
Definition
excess variation in shape
Term
What is anisocytosis?
Definition
excess variation in size
Term
Triad of symptoms associated with multiple myeloma?
Definition
back pain, anemia, and renal insufficiency
Term
Pentad for TTP?
Definition
FAT RN
Fever
Anemia
Thrombocytopenia

Renal dysfunction
Neurologic abnormalities
Term
Signs of sickle cell disease
Definition
Splenomegaly, Sludging
Infection
Cholelithiasis
Kidney-hematuria
Leg ulcers
Eye changes
Term
Percentage of sickle cell carriers?
Definition
10%
Term
What are shistocytes commonly associated with?
Definition
microangiopathic hemolytic anemias

TTP, HUS, DIC
Term
What are Howell-Jolly bodies associated with?
Definition
Sickle Cell Anemia
Term
What are target cells associated with?
Definition
Thalessemia and sickle cell
Term
What happens to the following in anemia of chronic disease:
Serum iron
TIBC
Ferriten
Definition
Serum iron: decreases
TIBC: decreases
Ferriten: increases
Term
Anemia symptoms
Definition
weakness
tiredness
light headed
HA
palpitations
Term
Anemia signs
Definition
pallor
hypotension
tachycardia
smooth tongue
cardiac arrhythmias
jaundice
hepatosplenomegaly
Term
What is melena?
Definition
black stool
Term
Causes for anemia
Definition
depletion of total body iron
blood loss
inadequate supply
defect in iron absoption
Term
Symptoms of iron deficiency anemia
Definition
easily tired
tachycardia
palpitation
SOB esp with exertion
Term
Signs of anemia
Definition
pallor(few signs unless advanced)
progressive mucosal skin changes
dysphagia due to esophogeal webbing (Plummer Vinson Syndrome)
Term
lab findings with iron deficiency anemia
Definition
hypochromic, microcytic, decreased MCV
Term
What happens to hemoglobbin with iron treatement for Fe deficiency anemia?
Definition
rises over 1-2 months, becomes replished in 6 months
Term
ADR of parenteral therapy iron tx
Definition
arthralgia, myalgia, fever, pruritis, lymphadenopathy, local pain, muscle necrosis
Term
#1 factor causing failure to respond to iron therapy
Definition
Non-compliance
Term
What is the Schilling test for?
Definition
B12 deficiency
Term
Causes for folic acid deficiency
Definition
decreased intake (alcoholics),
malabsorption (rare),
increased utilization (pregnancy),
use of folate antagonists (ie. methotrexate)
Term
Symptoms of folic acid deficiency
Definition
vague GI
anorexia
diarriah
Term
signs of folic acid deficiency
Definition
pale
mildly icteric
smooth tongue
Term
In which disease do you find Bence Jones Proteins?
Definition
Multiple myeloma
Term
In which disease do you find Bence Jones Proteins?
Definition
Multiple myeloma
Term
Hodgkins disease stages
Definition
I: 1 lymph node region involved
II: 2 regions on same side of diaphragm
III: 2 or > regions on both sides of the diaphragm
IV: disseminated dz

A=presence of constitutional sx
B=presence of fever, wt loss, night sweats
Term
Where do you find paraprotein formation?
Definition
multiple myeloma
Term
Median age of onset for non-hodgkins lymphoma?
Definition
50
Term
Stages of Chemotherapy
Definition
Induction
Consolidation
Intensification
Maintenence
Term
What is Fanconi's?
Definition
Inherited thrombocytopenia
aplastic anemia
Term
Where do you find decreased haptoglobin?
Definition
hemolytic anemia
Term
What does a positive Coombs test indicate?
Definition
autoimmune hemolytic anemia
Term
What are B symptoms?
Definition
fever, night sweats, fatigue, weight loss
Term
What are the tests for vWD?
Definition
factor VIII
vWF
RCof
Term
What are the tests for vWD?
Definition
factor VIII
vWF
RCof
Term
What is given for a heparin OD?
Definition
protamine sulfate
Term
Where do you find segmented neutrophils?
Definition
macrocytic anemias
Term
What are the symptoms for TTP?
Definition
Fever
Anemia
Thrombocytopenia
Renal disease
Neutopenia
Term
What can Ticlid cause?
Definition
TTP and neutropenia
Term
What are GP IIb/IIa receptor inhibitors and what do they do?
Definition
Aggrastat
Abciximax
Term
What do you use to treat HIT?
Definition
Levirudin
Term
What defines a blast crisis?
Definition
>25% blasts
Term
What % of African-Americans carry sickle cell trait?
Definition
10%
Term
What do you not give for TTP and ITP?
Definition
platelets
Term
Hypercoagulation states?
Definition
Protein C
Antithrombin III
Protein S
Factor V Leiden
Prothrombotin mutation
High homocystein level
Term
What is the test for hereditary spherocytosis?
Definition
Osmotic fragility test
Term
What can excess tea drinking cause?
Definition
Deficiency in iron absorption
(from tannins)
Term
What will be the folate level in folic acid deficiency?
Definition
<150 ng/ml
Term
course/prognosis in folic acid deficiency?
Definition
initally rapid improvement in "sense of well being" with blood correction in 2 months
Term
Risk factors for folic acid deficiency?
Definition
renal dialysis patients
cancer pts or chronic debilitating dx
patients on anticonvulsants, OC, isoniazid, antibiotics, chemotherapeutic agents
Term
What is myelopthisis?
Definition
Replacement of normal bone marrow by neoplastic cells (AML)
Term
What type of cells do you see with lead poisoning?
Definition
microcytic
Term
which disease is a neoplastic disease of plasma cells?
Definition
multiple myeloma
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