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In what disease can treatment with prednisone mask leukemia? |
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What happens to PT and PTT with hemophilias? |
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Definition
PTT prolonged
PT is normal |
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What are Heinz bodies associated with? |
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Definition
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Which leukemia characteristically shows a high WBC count? |
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What is philadelphia chromosome associated with? |
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Definition
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What are Reed-Sternberg cells associated with? |
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Definition
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What findings are commonly associated with myelofibrosis? |
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Definition
teardrop poilkiocytosis, nucleated RBC, giant platelets |
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Definition
excess variation in shape |
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Definition
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Triad of symptoms associated with multiple myeloma? |
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Definition
back pain, anemia, and renal insufficiency |
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Definition
FAT RN Fever Anemia Thrombocytopenia
Renal dysfunction Neurologic abnormalities |
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Signs of sickle cell disease |
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Definition
Splenomegaly, Sludging Infection Cholelithiasis Kidney-hematuria Leg ulcers Eye changes |
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Percentage of sickle cell carriers? |
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Definition
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What are shistocytes commonly associated with? |
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Definition
microangiopathic hemolytic anemias
TTP, HUS, DIC |
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What are Howell-Jolly bodies associated with? |
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Definition
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What are target cells associated with? |
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Definition
Thalessemia and sickle cell |
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What happens to the following in anemia of chronic disease: Serum iron TIBC Ferriten |
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Definition
Serum iron: decreases TIBC: decreases Ferriten: increases |
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weakness tiredness light headed HA palpitations |
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pallor hypotension tachycardia smooth tongue cardiac arrhythmias jaundice hepatosplenomegaly |
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Definition
depletion of total body iron blood loss inadequate supply defect in iron absoption |
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Symptoms of iron deficiency anemia |
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Definition
easily tired tachycardia palpitation SOB esp with exertion |
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Definition
pallor(few signs unless advanced) progressive mucosal skin changes dysphagia due to esophogeal webbing (Plummer Vinson Syndrome) |
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lab findings with iron deficiency anemia |
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Definition
hypochromic, microcytic, decreased MCV |
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What happens to hemoglobbin with iron treatement for Fe deficiency anemia? |
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Definition
rises over 1-2 months, becomes replished in 6 months |
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ADR of parenteral therapy iron tx |
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Definition
arthralgia, myalgia, fever, pruritis, lymphadenopathy, local pain, muscle necrosis |
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#1 factor causing failure to respond to iron therapy |
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Definition
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What is the Schilling test for? |
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Definition
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Causes for folic acid deficiency |
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Definition
decreased intake (alcoholics), malabsorption (rare), increased utilization (pregnancy), use of folate antagonists (ie. methotrexate) |
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Symptoms of folic acid deficiency |
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Definition
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signs of folic acid deficiency |
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Definition
pale mildly icteric smooth tongue |
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In which disease do you find Bence Jones Proteins? |
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Definition
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In which disease do you find Bence Jones Proteins? |
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Definition
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Definition
I: 1 lymph node region involved II: 2 regions on same side of diaphragm III: 2 or > regions on both sides of the diaphragm IV: disseminated dz
A=presence of constitutional sx B=presence of fever, wt loss, night sweats |
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Where do you find paraprotein formation? |
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Definition
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Median age of onset for non-hodgkins lymphoma? |
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Definition
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Definition
Induction Consolidation Intensification Maintenence |
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Definition
Inherited thrombocytopenia aplastic anemia |
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Where do you find decreased haptoglobin? |
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Definition
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What does a positive Coombs test indicate? |
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Definition
autoimmune hemolytic anemia |
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Definition
fever, night sweats, fatigue, weight loss |
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What are the tests for vWD? |
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Definition
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What are the tests for vWD? |
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Definition
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What is given for a heparin OD? |
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Definition
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Where do you find segmented neutrophils? |
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Definition
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What are the symptoms for TTP? |
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Definition
Fever Anemia Thrombocytopenia Renal disease Neutopenia |
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Definition
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What are GP IIb/IIa receptor inhibitors and what do they do? |
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Definition
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What do you use to treat HIT? |
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Definition
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What defines a blast crisis? |
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Definition
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What % of African-Americans carry sickle cell trait? |
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Definition
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What do you not give for TTP and ITP? |
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Definition
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Definition
Protein C Antithrombin III Protein S Factor V Leiden Prothrombotin mutation High homocystein level |
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What is the test for hereditary spherocytosis? |
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Definition
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What can excess tea drinking cause? |
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Definition
Deficiency in iron absorption (from tannins) |
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What will be the folate level in folic acid deficiency? |
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Definition
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course/prognosis in folic acid deficiency? |
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Definition
initally rapid improvement in "sense of well being" with blood correction in 2 months |
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Risk factors for folic acid deficiency? |
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Definition
renal dialysis patients cancer pts or chronic debilitating dx patients on anticonvulsants, OC, isoniazid, antibiotics, chemotherapeutic agents |
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Definition
Replacement of normal bone marrow by neoplastic cells (AML) |
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What type of cells do you see with lead poisoning? |
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Definition
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which disease is a neoplastic disease of plasma cells? |
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Definition
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