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Thyroid pharmacotherapy
Thyroid pathology pharmacotherapy
4
Medical
Professional
03/12/2011
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Term
De-iodinase 1
 Definition

T4 --> T3 (production of T3)

rT3 --> T2 (degradation of rT3)

 

located in liver, kidney, thyroid
Term
Deiodinase 2
 Definition

T4 --> T3 (local T3 production in brain, pituitary)

 
Term
D3
 Definition

- normally quiescent

- when induced in skeletal m. and liver T4 --> rT3

T3 --> T2

- protects tissues from excess T4 by converting to inactive forms

- location: brain, placenta, uterus (inducible in liver, m.)
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