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Thyroid Hormones
N/A
35
Physiology
Undergraduate 1
03/30/2015

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Term
Thyroid gland secretory cells form a what?
Definition
follicle.
Term
The follicle surrounds a what?
Definition
colloid.
Term
What is a colloid?
Definition
gel-like protein.
Term
What does a colloid consist of?
Definition
thyroglobulin.
Term
What is thyroglobulin?
Definition
precursoe protein from which thyroid hormones are formed.
Term
What are the major thyroid hormones?
Definition
T3 & T4.
Term
What are T3 and T4 made from?
Definition
tyrosine and iodine.
Term
What step is often blocked when hormones are being overproduced?
Definition
oxidation to iodine (I2).
Term
Because T3 and T4 aren't very water-soluble, they have to be carried through the circulation by what?
Definition
thyroxine-binding globulin.
Term
What is one of the main effects of thyroid hormones?
Definition
increase metabolic rate.
Term
Increased metabolic rate occurs by...
Definition
increased O2 consumption and heat production.
Term
Increased metabolic rate results in the breakdown of what?
Definition
fat and muscle.
Term
What are the effects of increased catecholamine action?
Definition
increased cardiac output.
Term
Thyroid hormones cause the stimulation of what?
Definition
GH secretion.
Term
Thyroid hormones promotes the development of what in children?
Definition
nervous system.
Term
Epinephrine and norepinephrine are examples of what?
Definition
catecholamines.
Term
What is cretinism?
Definition
hypothyroidism during growing years.
Term
Cretinism symptoms include:
Definition
infant-like body proportions, reduced mental development.
Term
Causes of hypothyroidism include:
Definition
dietary iodine deficiency, radioactive iodine, pituitary & hypothalamic failure.
Term
Symptoms of hypothyroidism include:
Definition
patient fatigues easily, poor cold tolerance, weight gain, slow pulse, myxedema, carotenemia, and goiters.
Term
What is myxedema?
Definition
accumulation of hyaluronic acid and chondroitin in skin.
Term
What does myxedema cause?
Definition
water retention.
Term
What is carotenemia?
Definition
carotene deposited in the skin.
Term
What are goiters?
Definition
enlarged thyroid.
Term
Why do goiters occur?
Definition
TSH levels are increased, promoting growth.
Term
Symptoms of hyperthyroidism include:
Definition
increased metabolic rate, weight loss, heat tolerance, irritability, increased heart rate, raise in temperature (sweating), and exophthalmos.
Term
What is exophthalmos?
Definition
bulging eyes.
Term
What is Grave's disease?
Definition
an autoimmune disease.
Term
What does Grave's disease cause?
Definition
hyperthyroidism.
Term
What causes Grave's disease?
Definition
body makes antibodies to TSH receptor.
Term
What are the antibodies that are made in Grave's disease?
Definition
thyroid stimulating immunoglobulin (TSI).
Term
What is the function of TSI?
Definition
stimulates TSH receptor.
Term
Increase T3 causes what to decrease?
Definition
TSH.
Term
Low thyroid + high TSH causes...
Definition
normal goiter.
Term
High thyroid + low TSH causes...
Definition
Grave's goiter.
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