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Therapeutics #3 - Renal Part 1
N/A
72
Pharmacology
Graduate
10/29/2009

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Term
Excretion Function of Kidneys
Definition
filtration - water & waste removal (including drugs); reabsorption - regulation of electrolytes; secretion
Term
Endocrine Functions of Kidneys
Definition
renin - regulation of BP; erythropoetin - regulation of RBC production; prostaglandins; kinin
Term
Metabolic Functions of Kidneys
Definition
Vitamin D activation - regulation of Ca levels; metabolism - endogenous compounds, CYP P450; gluconeogenesis
Term
Normal Glomerula Filtration Rate (GFR)
Definition
90 - 140 mL/min
Term
Amount of Filtered Na that is reabsorbed throughout tubules
Definition
65% in PCT, 25% in loop of Henle, 5% in early DCT and 5% in late DCT
Term
Water Tubular Reabsorption
Definition
osmotically reabsorbed (except in collecting duct); responds to ADH in late DCT and collecting duct
Term
Tubular Reabsorption of Amino Acids
Definition
reabsorbed via active transport
Term
Things Secreted into tubule
Definition
organic ions (creatinine, histamine); drugs & toxins (cimetidine, probenecid, trimethoprim); other electrolytes (K, H+)
Term
Normal Rate of Urine Production
Definition
produced at rate of 1 mL/min
Term
Renin
Definition
increases in response to decreased renal perfusion pressure; released from juxtaglomerular cells in afferent arterioles
Term
Angiotensin II
Definition
increased in response to renin; potent vasoconstrictor; stimulates catecholamine release
Term
Aldosterone
Definition
increased in response to Angiotensin II; stimulates Na & H2O reabsorption; promotes myocardial fibrosis & vascular dysfunction (tissue remodeling)
Term
Erythropoietin
Definition
endogenous hormone responsible for production of RBCs; 90% is created in kidney
Term
Vitamin D
Definition
some activation occurs in kidney; required for regulation of Ca & bone formation
Term
Acute Kidney Injury
Definition
sudden & rapid deterioration of renal fcn leading to electrolyte imbalances & inability to excrete nitrogenous waste products (azotemia); common complication in hospitalized pts (ICUs); usually reversible; 20% are drug-induced
Term
General Risk Factors of Acute Kidney Injury
Definition
advanced age; acute infection; pre-existing respiratory or cardiovascular disease; chronic kidney disease; dehydration; nephrotoxic drug use
Term
Clinical Manifestations of AKI
Definition
often assymptomatic; hyperkalemia; diminishing urine volume; increased Cr over SHORT period of time; fatigue, malaise, abdominal pain --> dyspnea, rales, peripheral edema --> arrhythmias, metabolic acidosis, altered mental status
Term
Pathophysiology of Prerenal Dysfunction (aka Prerenal Azotemia)
Definition
kidney hypoperfusion & decreased glomerular pressure; Physiologic response: maintain glomerular pressure & GFR --> activates SNA, activates RAAS, vasoconstriction of efferent arterioles & vasodilation of afferent arterioles, release of ADH
Term
Specific Pathophysiologies of Prerenal Dysfunction
Definition
decreased intravascular volume (blood loss, dehydration, hypoalbunimia); decreased systemic vascular resistance (hypotension, sepsis, anaphylaxis); decreased cardiac output (arrhythmias, HF, pulmonary HPN, valvular diseases); intrarenal hemodynamic changes (bilateral renal artery stenosis, hepatorenal syndrome, emboli, hypercalcemia, drug-induced)
Term
Drug-induced Prerenal AKI due to ACEIs or ARBs
Definition
occurs most often in renin-dependent states; 2 drug classes selectively dilate efferent arterioles, acutely decreasing glomerular perfusion pressure; especially harmful in hypovolemic/hypoperfusion states where RAAS has been activated (dilates afferent arterioles, constricts efferent arterioles); these drugs PREVENT constriction of efferent arterioles after RAAS activation, causing vasodilation, lowering GFR
Term
Drug-induced Prerenal AKI due to NSAIDs
Definition
in states of hypoperfusion, COX levels are increased to maintain glomerular perfusion pressure (dilation of afferent arterioles); these drugs inhibit COX, preventing vasodilation; especially harmful in states of hypoperfusion
Term
Most common cause of Prerenal AKI
Definition
dehydration
Term
Lab Eval of Prerenal AKI
Definition
elevated BUN & Cr; high BUN:Cr (> 20:1); low urine Na; FENA% < 1%; Urinalysis: yellow to dark yellow, SG elevated, Uosm is elevated, hyaline casts present
Term
Managment of Prerenal AKI
Definition
correct volume deficits (blood transfusion, IV fluids); removal of inciting agents; correction of electrolyte disturbances; monitoring or removal of drugs that may accumulate to cause toxicity; emergent dialysis if indicated
Term
Intrinsic Dysfunction
Definition
damage within the kidney or nephron; categorized by what structure is damaged: glomerulus, renal tubule, interstitium, vasculature
Term
Mechanisms of Glomerular Damage in Glomerulonephritis
Definition
systemic Ag-Ab complexes become trapped in glomerular capillaries (deposition): post-infectious glomerulonephritis, lupus nephritis, cryoglobulinemia; antineutrophil cytoplasmic antibodies (ANCA) formed against neutrophils & monocytes & do not cause immune deposits: Wegener's granulomatosis; Auto-Abs formed against glomerular basement membrane or epithelial cells: Goodpasture's syndrome
Term
Results of Glomerular Damage
Definition
1) reduction of glomerular surface area --> reduction in amount of ultrafiltrate; 2) increased permeability of glomerular capillaries --> increased loss of protein & blood
Term
Drug-induced Glomerulonephritis
Definition
usually nephrotic; caused by rifampin, lithium, GOLD, NSAIDs
Term
Factors that Progress Glomerulonephritis
Definition
systemic & intraglomerular HPN; high dietary protein; hyperlipidemia; coagulation; Ca & PO4 abnormalities
Term
Evaluation of Glomerulonephritis
Definition
UA with microanalysis; 24-hr urine collection (urine protein & creatinine); PE & Pt Hx; Test for Abs (ANCA, complement)
Term
Glomerulonephritis NephrOtic Syndrome
Definition
etiology: systemic dx, non-inflammatory; Signs: edema, weight gain, fatigue; Lab Findings: PROTEINURIA >3.5 g/day, hyperlipidemia, lipiduria, hypoproteinemia, hypercoagulable state
Term
Glomerulonephritis NephrItic Syndrome
Definition
Etiology: INFLAMMATORY; Signs: hematuria, HPN, edema, decline in renal fcn; Lab Findings: proteinuria, PUS IN URINE, CELLULAR & GRANULAR CASTS
Term
Management of Glomerulonephritis
Definition
Goal: Reduce proteinuria; General Approach: Immunosuppressives (controversial - corticosteroids, cytotoxic agents, cyclosporine or mycophenolate); Supportive Therapy: restriction of dietary protein, Na, cholesterol, management of HPN, edema, hyperlipidemia
Term
Acute Tubular Necrosis
Definition
cell death (necrosis) in tubule epithelium caused by prolonged or severe reduction in renal blood flow; Major Causes: ischemia (precursors: dehydration, shock, sepsis), nephrotoxins (exogenous: drugs, radiocontrast dye, heavy metals; endogenous: uric acid, myoglobin, hemoglobin); MOST COMMON CAUSE OF intrinsic renal failure
Term
General Risk Factors for Drug-induced ATN (acute tubular necrosis)
Definition
CKD, older age, concomitant drug use with other nephrotoxic or volume-depleting drugs, volume depletion, increased doses of nephrotoxic drugs
Term
Aminoglycoside-induced ATN
Definition
accumulation of aminoglycoside within epithelial cells of proximal tubule; inhibits phospholipases
Term
Amphotericin B-induced ATN
Definition
renal arterial vasoconstriction; direct toxicity to epithelial cell in distal tubule, altering cell permeability; additional risk factors: male sex, daily dose > or = to 35 mg, weight > or = to 90 kg
Term
Radiocontrast media-induced ATN
Definition
vasoconstrictors are released secondary to contrast media delivery to kidney --> reducing intrarenal perfusion (hemodynamic), direct toxicity to proximal tubule cells, occurs within 24-72 hrs after administration; Additional risk factors: DM, higher volume of media; Usually reversible
Term
Lab Evaluation of Acute Tubular Necrosis (ATN)
Definition
UA: brown-dark color, brown casts, renal tubular epithelium cells may be present; Urine Electrolytes: high urine Na, FENA%, low Uosm; In proximal tubular injury: hypokalemia, hypophosphatemia, hypomagnesemia, metabolic acidosis; In Distal Tubule Injury: hyperkalemia, metabolic acidosis, polyuria
Term
General Management of ATN
Definition
remove inciting agent; correction of electrolyte imbalances; monitor or removal of drugs that may accumulate to cause toxicity; emergent dialysis if indicated; IV fluid replacement; treatment of underlying problem
Term
Prevention of Toxicity from Exogenous Nephrotoxins in ATN
Definition
for aminoglycosides: drug level monitoring, risk increases with length of treatment (keep it short!); for Amphoterocin B: risk increases with higher dose & length of treatment, lipid-based formulations may be less nephrotoxic
Term
Prevention of Radiocontrast Media-induced ATN
Definition
avoid gadolinium-based agents; proper hydration before & after administration (NS vs NaHCO3); use of antioxidants (N-acetylcysteine [Mucomyst 600 mg PO BID day before & day of admin], ascorbic acid [Vitamin C])
Term
Interstitial Nephritis
Definition
occurs when interstitial tissue & surrounding tubule becomes inflamed; form of intrinsic dysfunction; hypersensitivity response; often present with fever, rash, arthralgias
Term
Major Causes of Interstitial Nephritis
Definition
drug-induced (most common): penicillins, sulfonamides, rifampin, cipro, NSAIDs, valproic acid, PPIs; Infectious diseases (bacterial & viral); idiopathic
Term
Lab Eval of Interstitial Nephritis
Definition
peripheral blood smear shows eosinophils; UA: WBCs, casts, eosinophils
Term
Management of Interstitial Nephritis
Definition
usually reversible; supportive management; for drug-induced: d/c drug, avoid rechallenge of drug; Possible corticosteroid therapy: methylprednisolone, prednisone
Term
Vasculitides
Definition
possible causes: occlusion of larger renal arteries by emboli (atherosclerotic, thrombus); microangiopathies: inflammation or occlusion of small vessels (diffuse renal vasculitis, polyarteritis, thrombotic); hemolytic uremic syndrome; accelerated HPN
Term
Lab Eval of Vasculitides
Definition
UA: RBCs, casts, Heme +, red color; Serum: increased LDH, schistocytes; Radiology: CT or MRI showing renal vein thrombosis
Term
Management of Vasculitides
Definition
Supportive Treatment of: hypoproteinemia, thromboembolism, hyperlipidemia (low-lipid diet), HPN (restrict salt intake), edema (restrict salt intake, support stockings, edema), proteinuria (restrict protein intake); Immunosuppression: high dose steroids, cyclophosphamide, cyclosporine, mycophenolate mofetil; Plasma exchange (plasmapheresis)
Term
Postrenal Azotemia
Definition
obstruction after nephron/kidney preventing urine flow out of tubule; Etiology: nephrolithiasis, urethral obstruction, BPH, uncommon causes (blood clots, bilateral ureteral stones), drug-induced; Pt presents with nausea, vomiting, fever, flank pain; can progress to intrinsic renal injury back into tubule
Term
Drug-induced Postrenal Azotemia
Definition
caused by anticholinergics (urinary retention); nephrolithiasis caused by: sulfonamides, foscarnet, allopurinol, acyclovir, methotrexate, indinavir; MoA of Nephrolithiasis: supersaturation of drug in urine forms crystals; Risk Factors for Nephrolithiasis: poor hydration, higher doses, longer treatment;
Term
Evaluation of Postrenal Azotemia
Definition
UA: little or no proteinuria, resembes prerenal azotemia initially (high Uosm, low urine Na, BUN:Cr > 20:1), once intrinsic injury has occurred (increased UNa, FENA% increases, other indices resemble intrinsic dx); Ultrasound to confirm obstruction
Term
Management of Postrenal Azotemia
Definition
increase fluid intake if due to nephrolithiasis; catheterization or stenting to relieve obstruction (results in diuresis --> possible dehydration, hydrate with IV fluids); pain management
Term
Normal Range for UA specific gravity
Definition
1.003 - 1.030
Term
UA protein
Definition
increased in glomerular injury
Term
BUN:Cr
Definition
normal range is about 10 - 15:1; increased in acute hypovolemia/hypoperfusion (prerenal azotemia) b/c BUN reabsorbs easily when GFR acutely slow & Cr is NOT reabsorbed easily
Term
UA Na Range
Definition
Normal range is 10-20 mEq/L
Term
FENA%
Definition
= [(UNa/SNa)/(UCr/SCr)]*100; normal range is 1-2%; >2% = renal tubule damage, decreased reabsorption of Na; <1% = prerenal dysfunction, increased Na reabsorption
Term
FEUN% (FeUrea)
Definition
< or = to 35% = prerenal dysfunction; > 50% = intrinsic renal dysfunction
Term
Urine osmolality (Uosm)
Definition
correlates with specific gravity; Increases when ADH is released/hypovolemia; decreased when renal tubule is damaged & cannot respond to ADH
Term
Lab Assessment of Pre-renal hypovolemia/hypoperfusion AKI
Definition
no cells, + hyaline casts; no or low protein; UNa < 20; Uosm > 400; UOsm:SOsm > 1.5; FENA% < 1%; BUN:Cr >20:1
Term
Lab Assessment of Intrinsic Acute Tubular Necrosis AKI
Definition
broad, brownish granular casts; no or low protein; UNa >30; UOsm <350; UOsm:SOsm < 1.3; FENA% >2%; BUN:Cr < 20:1
Term
Lab Assessment of Intrinsic Interstitial Nephritis AKI
Definition
white blood cells, eosinophils, white cell casts visible
Term
Lab Assessment of Intrinsic Glomerulonephritis AKI
Definition
RBCs visible, protein increased >100 mg/dL
Term
Lab Assessment of Post-renal Azotemia Obstruction AKI
Definition
no cells or bloody, red urine; low protein
Term
Glomerular Filtration Rate (GFR)
Definition
best indicator of renal fcn; expressed as volume of plasma filtered per unit time; normal range: 90 - 140 mL/min; cannot directly measure
Term
Rate of excretion =
Definition
rate of filtration + rate of secretion - rate of absorption
Term
Factors Affecting Serum Conc of Cr
Definition
gender (decreased in females); race (increased in blacks); diet (decreased in vegetarians, increased with higher meat consumption); muscular body habitus (increased); malnutrition, amputation, muscle wasting disease (decreased)
Term
Estimated Creatinine Clearance (Cockcroft-Gault Equation)
Definition
[(140-age)* weight (kg)]/[72 * SCr]; multiply by 0.85 for females; recommended only in stable renal fcn
Term
IBW (Ideal Body Weight) Equations
Definition
For males: = 50 kg +/- 2.3 for every inch above/below 60 inches; For females: = 45.5 kg +/- 2.3 for ever inch above/below 60"; Use ABW if ABW < IBW; Use IBW if ABW > IBW but < 120% of IBW
Term
Adjusted Body Weight for obese pts
Definition
if ABW > 120% IBW, then use this equation: = 0.4*(ABW-IBW) + IBW
Term
Modification of Diet in Renal Disease (MDRD) Study
Definition
based on age, gender, race, & Cr; used in pts with CKD risk factors & GFR < 60 mL/min/1.73 m^2; more accurate estimation of GFR than Cockcroft-Gault
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