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Therapeutics V: Exam #2 - Otitis Media & Otitis Externa
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47
Health Care
Graduate
01/12/2011

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Term
Effusion
Definition
escape of pus, serum, blood, lymph, or other fluid into a body cavity as a result of inflammation or presence of excess blood or tissue fluid in an organ or tissue
Term
Suppurative effusion
Definition
pus that is characterized by a creamy or thick yellow or white fluid in middle ear
Term
Serous effusion
Definition
a pale yellow or amber-colored fluid which is much less viscous
Term
Acute Otitis Media (AOM)
Definition
presence of fluid in middle ear caused by infection, allergy, or functional alterations of middle ear or eustachian tube
Term
Chronic Otitis Media
Definition
middle ear effusion which persists for longer than 2-3 months
Term
Factors increasing likelihood of OM
Definition
age related (peak: 6 months - 18 months);
Males > females;
Winter > any other time of year;
> Native American, Eskimo, & Caucasian;
poorer populations;
Term
Environmental or Host Factors increasing risk for OM
Definition
mother who smokes;
Down's Syndrome;
recurrent or concurrent URI or nasal congestion;
age at 1st episode;
day care;
HIV;
# of family members in household;
absence of breast feeding
Term
Bacterial Pathogens associated w/ AOM
Definition
Strep. pneumoniae;
Haemophilus influenzae;
Moraxella catarrhalis;
Sterile or nonpathogenic organisms
Term
Most Common Bacterial Pathogen associated w/ AOM
Definition
Streptococcus pneumoniae
Term
S/Sx of AOM
Definition
onset after "head cold";
rhinitis;
cough;
ear pain (otalgia) & ear pulling/rubbing;
vomiting &/or diarrhea;
fever;
transient hearing loss??
Term
Appearance of Tympanic Membrane due to AOM
Definition
red, bulging, impaired mobility
Term
Tympanometry
Definition
measures compliance of tympanic membrane;
lack of movement indicates OM
Term
Intracranial Complications of AOM
Definition
meningitis;
extradural & subdural abscesses;
otitic hydrocephalus;
lateral sinus thrombosis;
focal encephalitis;
Term
Extracranial Complications of AOM
Definition
tympanic membrane perforation;
mastoiditis;
facial paralysis;
hearing loss;
Term
Children at highest risk for MDRSP
Definition
children < 4 yrs w/ recurrent AOM;
children treated w/ multiple antibiotics;
children who attend large day care centers;
- START w/ HIGH DOSE Amoxicillin for ALL pts
Term
Beta-Lactamase production
Definition
Children on Amoxicillin prophylaxis or frequent antibiotics are at highest risk;
Primary change in therapy: use an anti-Beta-Lactamase antibiotic
Term
Chlamydia pneumoniae OM
Definition
MUST be treated w/ macrolides or tetracyclines
Term
acetaminophen dosing for AOM
Definition
10-15 mg/kg/dose q4-8 hrs prn;
NO MORE than 6 doses OR <2600 mg/day
Term
ibuprofen (Motrin or Advil) dosing for AOM
Definition
5-10 mg/kg/dose q6-8 hrs PRN;
Give w/ food; helps w/ pain but does not completely take it away
Term
Antihistamines & Decongestants
Definition
NOT SHOWN to be of benefit in tx of AOM
Term
antipyrine/benzocaine (Auralgan or Tympangesic)
Definition
analgesic/anesthetic ear drops utilized for 1-2 days for mild pain;
use cautiously, will NOT cure condition;
- will completely mask pain, taking away a Sx that can be easily monitored
Term
Step 1 - Determine if Observation Option is acceptable (age dependent)
Definition
< 6 months:
- Certain Diagnosis: antibacterial therapy;
- Uncertain Diagnosis: Antibacterial therapy;

6 months - 2 yrs:
- Certain Diagnosis: Antibacterial therapy;
- Uncertain Diagnosis: Antibacterial therapy if SEVERE ILLNESS, observation therapy if NON-SEVERE illness;

>2 yrs:
- Certain Diagnosis: Antibacterial therapy if SEVERE illness, observational therapy if NON-SEVERE;
- Uncertain Diagnosis: Observational therapy for 48-72 hrs
Term
Certain Diagnosis
Definition
meets all 3 of following:
- rapid onset
- S/Sx of middle ear inflammation;
AND
- signs of middle ear effusion
Term
Severe Illness
Definition
moderate-severe otalgia
or
fever >39 C
Term
Non-severe Illness
Definition
Mild otalgia;
&
fever <39 C in past 24 hrs
Term
Amoxicillin
Definition
INITIAL DRUG OF CHOICE;
Dose: 90 mg/kg/day divided BID to TID
Term
Amoxicillin/clavulanic acid (Augmentin)
Definition
If ESBLs are suspected, start on HIGH-DOSE: 90 mg/kg/day divided BID to TID
Term
Pts at Risk for Treatment Failure
Definition
age <2 yrs;
age <6 months at 1st onset of AOM;
recurrent AOM;
bilateral disease;
receiving continuous antimicrobial therapy;
large group day care centers;
Term
Amoxicillin/Clavulanate
Definition
Dose: 90 mg/kg/day divided BID-TID
- considered 1st line for Tx Failure UNLESS pt has been started on it as 1st antibiotic
Term
Treatment Failure
Definition
lack of clinical response within 72 hrs
Term
cefuroxime axetil (Ceftin), ceftriaxone (Rocephin), azithromycin (Zithromax)
Definition
alternative options for Treatment Failure behind Augmentin
Term
Tympanocentesis
Definition
deliberate puncture of tympanic membrane to allow for culture of fluid & decrease pressure/pain
Term
Assume same organism & tx w/ different antibiotic
Definition
for recurrent OM, if S/Sx occur within 1 month
Term
Assume new infection & treat as such
Definition
for recurrent OM, if S/Sx occur after 1 month
Term
Myringotomy or Chemoprophylaxis
Definition
for chronic OM, if >4 episodes of AOM in 6 months or >6 episodes in 12 months
Term
myringotomy tubes
Definition
use in pts who fail antibiotic thearpy or those w/ hearing loss;
- allows drainage of eustachian tube & middle ear;
- reduces recurrent episodes of AOM by 50% with an ear infection free period for 3 months
Term
Prevnar
Definition
13-valent immunization against STREP PNEUMONIAE MENINGITIS!!!
- NOT for ear infection;
- may have effect on ear infections but DOES NOT PREVENT it OVERALL!!!
Term
Otitis Externa
Definition
infection of the external ear canal
Term
Conditions that produce favorable environment for Otitis Externa
Definition
introduction of sharp object into ear canal (hair clip, paper clip, Q-Tip);
Introduction & accumulation of moisture in ear canal (i.e. Swimmer's Ear)
Term
Signs of Otitis Externa
Definition
pruritis;
otalgia;
fullness;
throbbing pain;
hearing loss
Term
Symptoms of Otitis Externa
Definition
edema;
erythema;
foul-smelling secretions;
cellulitis
Term
Common Causative Organisms of Otitis Externa
Definition
Pseudomonas aeruginosa;
Staph. aureus
Term
Tx of Otitis Externa
Definition
antibiotic & corticosteroid combination otic drops;
- corticosteroid decreases inflammation, allows Abx to access infection site;
- anti-inflammatory, antipruritic, vasoconstrictive activity;
- suspension is PREFERRED, but solution can be used;
Term
Colymycin S Otic
Definition
neomycin SO4 3.3%, Colistin SO4 3 mg/ml, hydrocortisone 1%;
- used in tx of otitis externa
Term
Cortisporin otic
Definition
Neomycin SO4 5 mg/mL, Polymixin-B SO4 100K U/mL, Hydrocortisone 1%
Term
General Ear Health
Definition
DO NOT INSERT ANYTHING INTO EAR - EVEN Q-TIPS!!!
If excessive ear wax:
- flush w/ warm water w/ ear bulb;
- if fails, use carbamide peroxide (DEBROX) - 5-10 gtts AU for 15 min BID to QID;
- if DEBROX fails, see MD;
Term
Soothing Agents
Definition
Similasan Ear Ache Relief (chamomila, mercurius solubiler, sulphur), Sweet Oil
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