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Therapeutics - Tuberculosis
Pathogenesis, Symptoms, extrapulmonary TB, Mantoux test, Therapy
13
Pharmacology
Undergraduate 4
10/22/2010

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Cards

Term
What is tuberculosis?
Definition
rod shaped, slow growing, aerobic bacteria
Term
What does TB infection depend on?
Definition
intimacy, duration of contact, degree of infectiousness, host defences
Term
What is happens after being infected with TB?
Definition

Remain dormant, activated;

Reach alveoli, multiply in alveoli macrophages, lysis;

Ingested by monocytes;

Bacteria replicate causing specific immune reactions causing tissue damage (tubercles)

Term
What is reactivation TB?
Definition
latent organism overcomes immunological control and starts replicating
Term
What is primary progressive TB?
Definition
failure to control initial replication after initial infection
Term
What is Miliary TB?
Definition
TB affecting more than one site
Term
What is the Mantoux test?
Definition

Identify those at high risk of developing TB from latent infection

Intradermal injection of TB purified protein derivative (PPD), watch for delayed type reation, measure diameter

Term
What is the standard short course treatment for 6 months?
Definition

Ioniazid, Rifampcin, Pyrazinamide, Ethambutol

 

Term
What TB drug is requires monitoring visual acuity?
Definition
ethambutol
Term
How does ethambutol work?
Definition
prevents incorporation of mycolic acid in bacterial cell wall
Term
How does rifampcin work?
Definition
inhibits bacteria RNA polymerase
Term
How does ioniazid work?
Definition
interferes with biosynthesis of mycolic acids (for cell wall)
Term
Babies of nursing mothers on ioniazid therapy should be given what?
Definition
pyrodoxine 5mg on days mothers take INH
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