Term
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Definition
rod shaped, slow growing, aerobic bacteria |
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Term
What does TB infection depend on? |
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Definition
intimacy, duration of contact, degree of infectiousness, host defences |
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Term
What is happens after being infected with TB? |
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Definition
Remain dormant, activated;
Reach alveoli, multiply in alveoli macrophages, lysis;
Ingested by monocytes;
Bacteria replicate causing specific immune reactions causing tissue damage (tubercles) |
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Term
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Definition
latent organism overcomes immunological control and starts replicating |
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Term
What is primary progressive TB? |
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Definition
failure to control initial replication after initial infection |
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Term
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Definition
TB affecting more than one site |
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Term
What is the Mantoux test? |
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Definition
Identify those at high risk of developing TB from latent infection
Intradermal injection of TB purified protein derivative (PPD), watch for delayed type reation, measure diameter |
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Term
What is the standard short course treatment for 6 months? |
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Definition
Ioniazid, Rifampcin, Pyrazinamide, Ethambutol
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Term
What TB drug is requires monitoring visual acuity? |
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Definition
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Term
How does ethambutol work? |
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Definition
prevents incorporation of mycolic acid in bacterial cell wall |
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Term
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Definition
inhibits bacteria RNA polymerase |
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Term
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Definition
interferes with biosynthesis of mycolic acids (for cell wall) |
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Term
Babies of nursing mothers on ioniazid therapy should be given what? |
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Definition
pyrodoxine 5mg on days mothers take INH |
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