Term
| Classic symptoms of PD due to decreased DA (3) |
|
Definition
rigidity
bradykinesia
postural instability |
|
|
Term
| Classic symptoms of PD due to relative increase of Ach (1) |
|
Definition
|
|
Term
|
Definition
Bradykinesia + one other classic s/sx
Supportive: treatment response, progression |
|
|
Term
|
Definition
1.) Exogenous DA (L-Dopa)
2.) D2 Agonist
3.) Prevent DA breakdown: AADCi & COMTi
4.) Prevent DA breakdown: MAOBi
5.) Decrease excess cholinergic
6.) Modulate neurotransmission |
|
|
Term
Valproic Acid
Enzyme effects, PPB, ADR, Therapeutic Range |
|
Definition
UGT inhibitor
High PPB
ADR: weight gain, teratogenicity, alopecia
Range: 50-150mcg/mL |
|
|
Term
Carbamazepine
Enzyme effects, ADR, Therapeutic Range, DDI |
|
Definition
CYP & autoinducer
ADR: SIADH -> hypnatremia, aplastic anemia -> low WBC
Range: 4-12mcg/mL
DDI w/levetiracetam |
|
|
Term
Phenytoin
Enzyme effects, ADR, PPB, Therapeutic Range, Dosing |
|
Definition
CYP inducer
ADR: extravasation due to antifreeze, nystagmus (dose-dep), gingival hyperplasia (idiosync)
High PPB
Range: 10-20mcg/ml; 1-2mcg/ml free
Dosing: Loading Dose & Maintenance Dose by weight; max dose due to kinetics |
|
|
Term
|
Definition
ADR: weight gain, sedation
Renal elim |
|
|
Term
|
Definition
ADR: weight gain, sedation
Renal elim |
|
|
Term
|
Definition
|
|
Term
Lamotrigine
Enzyme effects, ADR |
|
Definition
Metabolized by UGT (reduced by OCP; increased by valproic)
ADR: dose-dependent skin rash; AHS |
|
|
Term
|
Definition
| Cabamazepine, Phenytoin, Phenobarbital, Lamotrigine |
|
|
Term
|
Definition
Primidone
Rufinamide
Oxcarbazepine
Lacosamide
Zonisamide |
|
|
Term
Levetiracetam
ADR, DDI, Elim |
|
Definition
ADR: CNS & behavioral
DDI w/carbamazepine (ataxia & nystagmus)
Renal Elim |
|
|
Term
Oxcarbazepine
Enzyme effects, ADR |
|
Definition
3A4 inducer (decreases OCP)
ADR: hyponatremia, aplastic anemia (less than carbam) |
|
|
Term
Topiramate
Enzyme effects, ADR, Elim |
|
Definition
3A4 inducer (decreases OCP)
ADR: weight loss
*migraine relief
Renal elim |
|
|
Term
Zonisamide
ADR, Avoid When |
|
Definition
ADR: weight loss
Avoid in sulfa allergy; CrCl < 50mL/min |
|
|
Term
|
Definition
| fever, rash, eosinophilia |
|
|
Term
| AEDs possible in pregnancy? |
|
Definition
| You can give any 2nd Gen EXCEPT TOPIRAMATE! |
|
|
Term
|
Definition
|
|
Term
|
Definition
Pulmicort
ICS
**only safe drug for pregnancy |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Proventil/ProAir/Ventolin
SABA |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Advair ICS/LABA
Diskus -> 1puff BID
HFA -> 2 puff BID |
|
|
Term
|
Definition
Symbicort ICS/LABA
2 puff BID |
|
|
Term
|
Definition
Dulera ICS/LABA
2 puff BID |
|
|
Term
| theophylline metabolism inhibitors (6) |
|
Definition
EtOH
Zileuton
Cimetidine
Zafirlukast
Propranolol
Ciprofloxacin |
|
|
Term
| theophylline metabolism inducers (6) |
|
Definition
Smoking
Rifampin
Phenytoin
Omeprazole
Phenobarbital
Carbamazepine |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Zyflo
5-lipoxygenase inhibitor |
|
|
Term
|
Definition
Xolair
Mab against IgE binding mast cells
Dosing based on body weight & serum IgE |
|
|
Term
|
Definition
|
|
Term
|
Definition
Combivent, DuoNeb
SABA/SAMA |
|
|
Term
|
Definition
|
|
Term
| theophylline blood levels |
|
Definition
|
|
Term
| Major Criteria for Abx Use in COPD (3) |
|
Definition
1.) increased dyspnea
2.) increased sputum
3.) sputum purulence |
|
|
