Term
SA node AV node Bundle of His Bundle branches Purkinje fibers involved in electrical impulse conduction, don't have as many contractile proteins but have a lot of ion channels |
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Definition
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Term
atrial and ventricular myocytes cardiac myocytes, participate in pumping action many contractile proteins but not as many ion channels |
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Definition
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Term
originates in the sinoatrial (SA) node. The impulse is conducted through internodal fibers to the atrioventricular (AV) node and then through the bundle of His, bundle branches, and Purkinje fibers to the ventricular muscle. |
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Definition
flow of electrical impulse through the heart |
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Term
P wave: atrial depolarization QRS complex: ventricular depolarization T wave: ventricular repolarization PR interval: conduction time through the AV node QT interval: time between ventricular depolarization and repolarization |
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Definition
On an EKG, what does the P wave, QRS complex, T wave, PR interval, and QT interval represent? |
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Term
0: ventricular depolarization is caused by sodium influx through the fast sodium channel. 1: the membrane is transiently repolarized as a result of potassium eflux 2: the membrane potential is relatively stable because of the concurrent influx of calcium and efflux of potassium 3: repolarization is caused by continued potassium efflux as calcium influx declines 4: ion balance is returned to normal by the action of the sodium pump (Na/K/ATPase). Ca is removed from the cell by the Na/Ca exchanger and CaATPase |
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Definition
[image] what does each phase represent? |
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Term
phase 0 (depolarization) is due to Ca influx instead of Na in nodal tissue there is more abundant Ca channels |
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Definition
Why do the SA node and AV node have a rounder curve? [image] |
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Term
1) alteration in slope of phase 4: NE stimulates opening of a greater number of pacemaker channels that leads to faster phase 4 depolarization. higher number of contractions in the same period of time 2) alteration in threshold potential: NE stimulates opening of a greater number of Ca channels and thereby shifts threshold potential to more negative potential. increases HR. 3) alteration in maximum diastolic potential: Ach makes the maximum diastolic potential more negative by increasing the probability of K channels opening, reduces the slope of phase 4, shifts threshold potential to more positive potential. decreases heart rate [image] |
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Definition
3 ways heart rate can be regulated |
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Term
coronary ischemia and tissue hypoxia electrolyte disturbances overstimulation of the sympathetic nervous system general anesthetics drugs the perturb cardiac transmembrane potential |
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Definition
pathophysiology of arrhythmias, causes |
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Term
altered automaticity is an abnormal impulse formation, it can be caused by any change that decreases the time required for depolarization from the maximal diastolic potential to the threshold potential. increased automaticity occurs if the rate of diastolic repolarization (the slope of phase 4) in the SA node or in latent pacemakers is increased. It also occurs if a shift of the threshold potential occurs to a more negative value or if a shift occurs of the maximum diastolic potential to a more positive value. phase 4 slope: increased by sympathomimetic drugs and hypokalemia, decreased by Ach threshold potential: Ca channel blockers make it less negative (takes longer to reach threshold) maximum diastolic potential: Ach makes it more negative duration of action potential: K channel blockers increase [image] |
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Definition
what can cause altered automaticity? |
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Term
triggered automaticity is an abnormal impulse formation [image] absolute refractory period: Na channel is inactivated and cannot be activated again (needs to go through resting phase) early afterdepolarization or torsade de pointes: distinctive form of polymorphic ventricular tachycardia characterized by a gradual change in the amplitude and twisting of the QRS complexes around the isoelectric line. it is associated with a prolonged QT interval, which may be congenital or acquired. It usually terminates spontaneously but frequently recurs and may degenerate into ventricular fibrillation drugs that cause EAD: class 1A drugs - quinidine, procainamide, disopyramide. Class III drugs - amiodarone, sotalol, dofetilide, ibutilide drugs that cause DAD (tachycardia with AV block): digoxin Drugs that cause DAD (ventricular tachycardia): increased sympathetic tone, myocardial ischemia/reentry |
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Definition
causes of triggered automaticity |
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Term
reentry of ventricular tissue - abnormal impulse conduction |
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Definition
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Term
AV node reentry - abnormal impulse conduction most common electrophysiologic mechanism responsible for paroxysmal supraventricular tachycardia. reentry occurs when a premature atrial depolarization arrives at the AV node and finds that one pathway (B) is still refractory from the previous depolarization. The other pathway (a) is able to conduct the impulse to the ventricle. Retrograde conduction of the impulse through pathway B leads to reentry of the atrium and results in tachycardia. In the AV node, the unidirectional block results from the B pathway's longer refractory period, which blocks anterograde conduction but permits retrograde conduction after it has recovered its excitability. |
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Definition
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Term
tissue damage by trauma, ischemia, or scarring drug induced block (*digoxin*, *BB*, *verapamil*) *conduction block can be manifested clinically as bradycardia* |
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Definition
causes of conduction block |
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Term
Wolff-Parkinson-White syndrome: abnormal impulse conduction [image] atrioventricular re-entrant tachycardia: an accessory atrioventricular connection is present (light blue). A premature atrial impulse blocks the accessory pathway (1) and propagates slowly through the AV node and conducting system. On reaching the accessory pathway (by now no longer refractory), the impulse re-enters the atrium (2), where it can then re-enter the ventricle via the AV node and become self sustaining. |
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Definition
impulses originate at the SA node and preexcite peripheral conduction system and ventricular muscle via bundle of Kent without delay at AV node. after normal delay at AV node, impulses also arrive at ventricles via normal route to continue depolarization. P wave is immediately followed by short delta wave, producing slurred upstroke on wide QRS with short or no PR interval |
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Term
AV nodal blocking drugs that terminate this tachycardia (with caution will slow conduction through the AV node): Ca channel blockers, BB, digoxin drugs that remove atrial premature beats catheter ablation: removal of Bundle of Kent |
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Definition
treatment for WPW syndrome |
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Term
sympathomimetic drugs: can increase automaticity of the SA node, AV node, or His-Purkinje fibers and thereby produce tachycarida digitalis glycosides: sometimes evoke delayed afterpolarizations by increasing Ca influx into cardiac cells, they can also impair AV node conduction and cause AV block Drugs that cause torsades de pointes: antiarrhythmic drugs (quinidine, sotalol), H1 antagonists (astemizole and terfenadine - removed from market due to cardiac side effects), psychotropic drugs (phenothiazides); these drugs prolong action potential by blocking K efflux |
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Definition
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Term
disopyramide, procainamide, quinidine |
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Definition
class 1A antiarrhythmic drugs |
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Term
lidocaine, mexiletine, phenytoin |
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Definition
Class 1B antiarrhythmic drugs |
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Term
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Definition
Class 1C antiarrhythmic drugs |
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Term
beta blockers: esmolol, metoprolol, propranolol |
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Definition
Class II antiarrhythmic drugs |
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Term
amiodarone, sotalol, dofetilide, ibutilide |
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Definition
Class III antiarrhythmic drugs |
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Term
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Definition
Class IV antiarrhythmic drugs |
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Term
adenosine, magnesium sulfate, digoxin |
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Definition
Class V antiarrhythmic drugs |
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Term
decrease automaticity in SA node: shift threshold to more positive potential, decrease slope of phase 4 decrease likelihood of reentry: decrease conduction velocity, increase refractory period (*1A*) state dependent ion channel block: most Na channel blockers bind preferentially to the open and inactivated states of Na channel, not to the closed state of the channel (*ischemic tissue: depolarized for a longer period of time*) [image] [image] dissociation rate of ion channel block: [image] [image] |
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Definition
mechanism of action of Class 1A antiarrhythmic agents |
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Term
quinidine, procainamide, disopyramide a moderate block on Na channels *preferentially bind to open Na channels* recovery time moderate decreases phase 0 upstroke velocity, which decreases conduction velocity through the myocardium *also block K channels, increases refractory period* prolonged repolarization of both SA nodal cells and ventricular myocytes all the Class 1A drugs have some degree of anticholinergic effects (significant clinically because it can increase conduction velocity through the AV node) |
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Definition
mechanism of action of Class 1A antiarrhythmic agents |
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Term
Class 1A antiarrhythmic drug diarrhea: often responsible for discontinuation of its use torsade de pointes: can cause syncope secondary to a reduction in CO and blood pressure thrombocytopenia cinchonism (higher doses): neurological symptoms including tinnitus, dizziness, and blurred vision quinidine induced digoxin toxicity: ***increases serum levels of digoxin*** *atrial flutter = 300 bpm with 2:1 AV block, with quinidine = 200 bpm with 1:1 AV conduction, recommendation = use quinidine with BB or verapamil. (quinidine has actions on the AV node, it can permit more impulses to get through to the ventricles, use of BB or verapamil with quinidine will eliminate some of the impulses) |
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Definition
adverse effects of quinidine |
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Term
Class 1A antiarrhythmic agent long term use of procainamide often causes a syndrome that resembles *lupus erythematosus*, presents arthralgia and a butterfly rash on the face, but is reversible this adverse effect is often responsible for discontinuation of the drug |
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Definition
adverse effects of procainamide |
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Term
Class 1A antiarrhythmic agent is administered orally to prevent *life threatening sustained ventricular tachycardia* (limited usage?) is sometimes effective in patient who have not responded to other drugs disopyramide has electrophysiological effects similar to those of quinidine because it has greater *negative inotropic* and *anticholinergic* effects than other class 1A agents, is should be used with caution in patients with heart failure and in elderly patients |
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Definition
mechanism of action of disopyramide |
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Term
lidocaine, mexiletine, phenytoin preferentially binds to both open and inactivated Na channels (*I>O*) fast dissociation from Na channels (Na channels recover quickly from Class 1B blockade) recovery time is rapid exhibit *use dependent block* - effective for ischemic cells (ischemic cells are usually in the open state) |
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Definition
mechanism of action of Class 1B antiarrhythmic agents |
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Term
Class 1B antiarrhythmic agents used most commonly to treat ventricular arrhythmias (***ventricular fibrillation and ventricular tachycardia***) in emergency situations associated with myocardial ischemia a high serum concentration of lidocaine can cause CNS side effects such as confusion, dizziness, seizure a drug that inhibits CYP450 enzymes (***cimetidine***) can precipitate lidocaine toxicity |
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Definition
mechanism of action of lidocaine |
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Term
Class 1B antiarrhythmic agent an analog of lidocaine metabolite the primary indication for mexiletine is life threatening *ventricular tachycardia* major adverse effects include dose related nausea and tremor |
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Definition
mechanism of action of mexiletine |
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Term
Class 1B antiarrhythmic agent usually considered an antiepileptic medication effective in ventricular tachycardia in young children also used to treat ventricular tachycardia after congenital heart surgery has been used in the treatment of congenital prolonged QT syndrome when mono therapy with BB has failed an inducer of hepatic enzymes (CYP450 3A4) |
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Definition
mechanism of action of phenytoin |
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Term
flecainide, propafenone preferentially binds to both open and inactivated Na channels (*I=O*) recovery time prolonged most potent Na channel blockers has little or no effect on action potential suppress premature ventricular contractions prevent paroxysmal supraventricular tachycardia and atrial fibrillation marked depressive effects on cardiac function |
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Definition
mechanism of action of class 1C antiarrhythmic agents |
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Term
Class 1C antiarrhythmic agent used to treat various atrial and ventricular arrhythmias flacainide is no longer used to treat ventricular arrhythmias associated with myocardial infarction because it increased the mortality rate (Cardiac Arrhythmia Suppression Trail) other adverse effects include bronchospasm, leukopenia, thrombocytopenia, seizures. |
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Definition
mechanism of action of flecainide |
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Term
class 1C antiarrhythmic agent used to treat various atrial and ventricular arrhythmias has a potential to cause ventricular arrhythmias and several hematologic abnormalities, including agranulocytosis, anemia, and thrombocytopenia |
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Definition
mechanism of action of propafenone |
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Term
esmolol, metoprolol, propranolol decrease automaticity by decreasing the slope of phase 4 decreases the incidence of reentry by slowing electrical conduction at the AV node the AV node is more sensitive than the SA node to the effects of BB the most frequently used agents in the treatment of supraventricular and ventricular arrhythmias *precipitated by sympathetic stimulation* |
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Definition
mechanism of action of Class II antiarrhythmic agents |
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Term
block K channels prolong action potential duration decrease the incidence of reentry by increasing the effective refractory period Class III antiarrhythmic agents increase the likelihood of developingearly afterdepolarization and torsade de pointes |
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Definition
mechanism of action of Class III antiarrhythmic agents |
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Term
Class III antiarrhythmic agent also acts as a class I, class II, and class IV antiarrhythmic alters the lipid membrane in which ion channels and receptors are located decreases reentry by prolonging the action potential duration decreases the rate of firing in pacemaker cells as a class I agent exert class II antiarrhythmic activity by noncompetitively antagonizing B-adrenergic receptors can cause significant AV nodal block and bradycardia used to treat atrial fibrillations |
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Definition
mechanism of action of amiodarone |
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Term
adverse cardiovascular effects: hypotension, AV block, various arrhythmias other adverse effects: blue-gray skin discoloration, thyroid abnormalities, fatal pulmonary fibrosis it can also cause corneal deposits, blurred vision, photosensitivity, and GI disturbances amiodarone inhibits the metabolism of other drugs: digoxin, flecaininde, phenytoin, procainamide, warfarin |
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Definition
adverse effects and interactions of amiodarone |
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Term
Class III antiarrhythmic agent used to terminate *atrial fibrillation and atrial flutter* the major adverse effects of these drugs are torsade de pointes, which may require electric cardioversion |
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Definition
mechanism of action of ibutilide and dofetilide |
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Term
a mixed class II and class III antiarrhythmic agent used to treat severe ventricular arrhythmias, especially in patients who cannot tolerate the side effects of amiodarone also used to prevent recurrent atrial flutter and fibrillation can cause fatigue and bradycardia can induce torsade de pointes |
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Definition
mechanism of action of sotalol |
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Term
block cardiac Ca channels act preferentially on AV and SA nodal tissues the major therapeutic actions of class IV antiarrhythmics is to slow the action potential upstroke in AV nodal cells, leading to slowed conduction velocity through the AV node used to treat re-entrant paroxysmal supraventricular tachycardia that involves the AV node |
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Definition
mechanism of action of Class IV antiarrhythmic agents |
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