Term
age > 55 gender race family history of stroke low birth weight |
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Definition
nonmodifiable risk factors of stroke |
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Term
HTN ***the single most important risk factor of ischemic stroke*** Afib ***increases risk of stroke 6 times*** other cardiac causes (CAD, CHF, LVH) atherogenic states (diabetes, dyslipidemia, cigarette smoking) alcohol abuse |
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Definition
modifiable risk factors of stroke |
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Term
oral contraceptives migraine high levels of homocysteine sleep apnea/snoring drug abues (cocaine, amphetamines, heroin) |
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Definition
potentially modifiable/unproven risk factors for stroke |
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Term
control of HTN: HTN - 70% of strokes, BP control can decrease the risk of stroke by 35-40% smoking cessation control of DM cholesterol reduction treatment of atrial fibrillation: CHADS2 score |
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Definition
what can be done for primary prevention of a stroke? |
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Term
seek immediate medical attention for sudden: numbness or weakness of the face, arm/leg (especially on one side of the body), confusion, trouble speaking or understanding, trouble seeing in one or both eyes, trouble walking, dizziness, loss of balance or coordination, severe headache with no known cause Act FAST: face, arm, speech, time |
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Definition
patient education on stroke |
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Term
normal cerebral blood flow (CBF) is 50mL/100g/min cerebral autoregulation: cerebral blood vessels dilate and constrict in response to BP changes to maintain cerebral blood flow despite BP fluctuation. Cerebral autoregulation can be impaired by artherosclerosis and injury. ischemia: local cerebral blood flow decreased to less than 20mL/100g/min infarction (irreversible brain tissue damage): local cerebral blood flow persistently less than 12mL/100g/min. ischemic tissue surrounding an infracted area is called the ischemic penumbra and can potentially be saved carotid artherosclerosis or cardiac issues can cause ischemic stroke |
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Definition
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Term
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Definition
mechanism of stroke via carotid atherosclerosis pathway and cardiac flow issue pathway (AFib, vavlular, etc) |
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Term
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Definition
abrupt onset focal neurologic deficit at least 24 hours presumed vascular origin |
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Term
transient ischemic attake (TIA) |
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Definition
abrupt onset focal neurologic deficit less than 24 hours (usually 30 minutes) |
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Term
symptoms: unilateral weakness, inability to speak, loss of vision, vertigo/feeling of falling, headache (more severe with hemorrhagic stroke) signs (dependent upon area affected): neurological dysfunction, hemi- or monoparesis (weak or paralyzed on one or both sides of the body), aphasia (can't speak), dysarthria (difficulty speaking, slurred speak), visual field defects, altered level of consciousness |
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Definition
signs and symptoms of stroke |
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Term
PE, history, and clinical presentation testing: CT scan of head: may take 24 hours to reveal area of infarction, preferred method of diagnosis, ischemic areas will be dark, hemorrhage will appear white MRI of head: reveal areas of ischemia with higher resolution and sooner than CT carotid doppler: determine if high degree of stenosis in carotid arteries supplying blood to the brain ECG: determine presence of AFib TTE: evaluate for valve abnormalities or wall-motion abnormalities as embolic sources to the brain TEE: more sensitive test for thrombus in left atrium |
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Definition
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Term
National Institutes of Health Stroke Scale (NIHSS) scored based on level of consciousness, motor function, sensory function, and language ability possible scores range from 0 to 42 scores less than 3-4 have excellent chance for complete recovery, scores greater than 20 predict poor outcomes |
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Definition
what scale determines the prognosis of a patient who has had a stroke? |
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Term
anticoagulation or thrombolytic therapy |
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Definition
risk factors that a stroke will develop into a hemorrhagic stroke |
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Term
reduce ongoing neurologic injury and decrease mortality/long term disability prevent complications from immobility and neurologic dysfunction prevent stroke recurrence |
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Definition
goals of therapy for stroke |
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Term
tissue plasminogen activator (t-PA) |
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Definition
thrombolytic therapy to restore or improve perfusion to the penumbra binds to fibrin in a thrombus and converts bound plasminogen to plasmin plasmin is responsible for clot dissolution and initiates local fibrinolysis adverse reactions and monitoring: bleeding - monitor Hgb/Hct, signs/symptoms of bleeding, monitor for mental status changes outcomes: 3 month outcomes significantly improved, intracerebral hemorrhage increased but no increase in mortality or disability |
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Term
0.9 mg/kg IV total dose max 90mg 10% as bolus remainder as infusion over 1 hour |
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Definition
what is the dose for t-PA? |
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Term
age 18 years or older clinical diagnosis of ischemic stroke causing a measurable neurologic deficit time to symptom onset is well established to be less than 3-4.5 hours before treatment would begin |
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Definition
inclusion criteria for t-PA use in acute ischemic stroke |
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Term
intracranial or subarachnoid bleeding (or history) other active/recent internal bleeding recent intracranial surgery, head trauma, stroke BP > 185/110 mmHg at the time of treatment seizure at stroke onset intracranial neoplasm, arteriovenous malformation, aneurysm active treatment with warfarin, heparin, platelets < 100,000 or INR > 1.7 current pregnancy or lactation |
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Definition
exclusion criteria for t-PA use in acute ischemic stroke |
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Term
age > 80 oral anticoagulant use basline NIHSS score > 25 history of stroke and DM |
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Definition
additional exclusions for t-PA use in acute ischemic stroke within 4.5 hours of event. |
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Term
reducing the formation of brain edema lessening the risk of hemorrhagic transformation or the infarction preventing further vascular damage forestalling early recurrent stroke aggressive BP lowering could worsen hypoperfusion |
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Definition
benefits of BP control in stroke patients |
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Term
NOT eligible: treat SBP > 220 or DBP > 140, goal of lowering BP 10-15% from baseline eligible: treat SBP > 185 or DBP > 110, goal of maintaining BP < 185/110 use short acting agents such as labetolol or nicardipine (CCB) with strong cerebral and coronary vasodilatory activity |
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Definition
BP recommendations for patient not eligible for thrombolytics and patients eligible for thrombolytics |
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Term
aspirin: 325 mg da withing 24-48 hours of onset, wait 24 hours if patient given t-PA venous thromboembolism prophylaxis: low dose subq heparin or LMWH, hold therapy for 24 hours if patient received t-PA |
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Definition
acute therapy for ischemic stroke |
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Term
swallow evaluation - appropriate feeding based on ability to swallow speech therapy physical therapy occupational therapy social support palliative care when appropriate |
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Definition
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Term
consider carotid endarterectomy depending on stenosis and other factors reduce risk factors: control BP and lipids antiplatelet therapy recommended for non-cardioembolic ischemic stroke: aspirin - 50-325 mg da, if patient has additional stroke while taking aspirin, no evidence that increasing aspirin dose will provide additional benefit, 27-30% risk reduction of stoke. clopidogrel - 75 mg po da, 8.7% risk reduction compared to ASA, not studied in acute ischemic stroke. ER dipyridamole/IR aspirin (aggrenox) - 37% risk reduction of stroke, not studied in acute ischemic stroke antihypertensive therapy with ACEi and diuretic: caution lowering within first 7 days of stroke (potential for decreased cerebral blood flow) lipid lowering therapy: stroke/TIA are coronary equivalents, LDL goal < 100 or < 70, statin therapy should be considered regardless of baseline cholesterol levels patients with cardioembolic stroke: warfarin with INR goal 2-3 if the patient has AFib, pts with certain heart valves may require higher INR goals |
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Definition
secondary prevention of ischemic stroke |
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Term
intracerebral hemorrhage (ICH) |
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Definition
bleeding into the brain with formation of hematoma greater morbidity/mortality than ischemic stroke risk factors: male, age > 60 years, HTN, excessive alcohol intake, thrombolytic or anticoagulation therapy an artery suddenly bursts blood released within brain tissue: damage the brain tissues, cause a stroke, sudden increase in the pressure inside the skull blood in brain damages surrounding tissues (mechanical effect, neurotoxicity of blood components and degradation products) 30% continue to enlarge over first 24 hours clot volume = most important predictor or outcome signs/symptoms: headache, focal neurologic deficits, decreased level of consciousness |
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Term
subarachnoid hemorrhage (SAH) |
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Definition
bleeding occurs withing the subarachnoid space caused by trauma or spontaneous risk factors: age > 40 years, female, cigarette smoking, HTN, excessive alcohol use cerebral aneurysm: abnormal outpouching of an artery, rupture, release of blood into the subarachnoid space (between the skull and brain), sudden increase in pressure inside the skull signs/symptoms: sudden and unusually severe headache, N/V, decreased or loss of consciousness, difficulty speaking, visual defects, hemiparesis |
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Term
general supportive care, typically in ICU management of BP if SPB > 200 or MAP > 150 often surgical intervention: place a metal clip at the base of aneursym, remove abnormal vessels comprising an arteriovenous malformation, endovasular procedures (less invasive) - catheter introduced through a major artery in leg or arm, guided to the aneurysm or AVM, deposits a mechanical agent such as a coil to prevent rupture |
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Definition
treatment of hemorrhagic stroke |
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Term
control of HTN smoking cessation avoidance of heavy alcohol intake avoidance of cocaine use |
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Definition
secondary prevention of hemorrhagic stroke |
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