Term
How long may antidepressant drug therapy take to take effect? |
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Definition
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Term
How long may antidepressants take to reach full effect? |
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Definition
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Term
How long antidepressant therapy go for following single episode? |
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Definition
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Term
How long may antidepressant therapy last following multiple episodes of depression? |
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Definition
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Term
What are the common side effects of SSRIs? |
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Definition
Nausea, diarrhoea, dry mouth, dizziness, headache, hyponatraemia |
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Term
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Definition
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Term
What are the symptoms of hyponatraemia? |
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Definition
Nausea, malaise (feeling of uneasiness), headache, confusion, stupor (lack of critical cognitive function) |
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Term
What are the normal levels for hyponatraemia? |
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Definition
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Term
When is hyponatraemia more likely? |
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Definition
SSRIs used in elderly
SSRIs used concomitant with diuretic |
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Term
What are the symptoms of withdrawal from SSRIs |
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Definition
dizziness, headache, anxiety, agitation, nausea, paraesthesiae
more common in drugs with shorter half-lives |
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Term
What side-effect may occur in initial fluoxetine therapy? |
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Definition
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Term
What are common side effects of TCAs? |
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Definition
Sedation
Weight gain
Anticholinergic (dry mouth, blurred vision, constipation)
GIT complaints common |
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Term
Which TCA is more sedative? |
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Definition
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Term
Which TCA has less antimuscarinic effects and less hypotensive effects? |
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Definition
Lofepramine (active metabolite is desipramine) |
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Term
Which type of MAOI does not interact with food stuffs? |
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Definition
Selective and reversible (Moclobemide) |
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Term
What does moclobemide selectively inhibit? |
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Definition
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Term
What type of drug class does venlafaxine belong to? |
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Definition
NSRI- Serotonin and Nor-adrenaline Reuptake Inhibitor |
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Term
Higher doses of Venlafaxine is associated with what particular side effect? |
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Definition
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Term
How may the GI adverse effects of Venlafaxine moderated? |
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Definition
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Term
In what scenario may velafaxine be more effective than SSRIs? |
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Definition
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Term
What advantages of venlafaxine have over older drugs? |
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Definition
Don't have the anticholinergic, cardiac, or toxic effects. |
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Term
What are the mechanisms of action of Mirtazepine? |
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Definition
Post-synaptic blockade of 5HT2 and 5HT3
Pre-synaptic blockade of central alpha2-adrenergic inhibitory autoreceptors |
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Term
What side-effect is particular to Mainserin? |
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Definition
neutropenia - monthly blood counts during 3 month therapy |
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Term
What is the drug of choice for mania? |
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Definition
Lithium carbonate
Carbamazepine
Diazepam |
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Term
What should be tested before commencing therapy with Lithium Carbonate? |
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Definition
renal, cardiac, and thyroid function |
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Term
What is the optimal Cp range for Lithium carbonate in prophylaxis of mania? |
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Definition
0.5-0.8 mmol/L (1 mmol/L for acute treatment) |
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Term
When is the blood concentration of Lithium carbonate measured to assess Cp? |
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Definition
12 hours after administration |
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Term
What are the side-effects associated with Lithium carbonate? |
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Definition
tremor, thirst, polyuria, weight gain, lethargy |
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Term
What is the prophlactic choice of agent for bipolar disorder? |
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Definition
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