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The Cardiovascular System
Dr. Lokuta lecture notes
18
Physiology
Undergraduate 4
04/15/2012

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Term
Artery vs. Vein
Definition
artery away from heart
vein to heart
Term
Perfusion definition
Definition
passage of blood or fluid through a vascular bed
Term
parallel vs series vascular beds
Definition
be able to locate and 3 advantages??
Term
Functional heart anatomy
Definition
superior/inferior vena cava
right atrium
tricuspid atrioventricular valve
chordae tendinae
papillary muscles
right ventricle
pulmonary semilunar valve
r and l pulmonary arteries
r and l pulmonary veins
left atrium
biscupid AV valve
l ventricle
aorta
Term
layers of heart
Definition
endocardium
myocardium
ectocardium
pericardial fluid/space and pericardium
(secretory lining and outer fibrous covering) function to decrease friction due to beating heart
Term
septums
Definition
interatrial and interventricular septums
Term
heart valves purpose and pressure
Definition
purpose: to promote a one way direction of blood flow
pressure gradients induce opening nad closing
Term
Cardiac all three types
Definition
sliding filaments
atp power
elevated Ca++ triggers contraction
Term
cardiac similar to skeletal -5
Definition
has sarcomeres
is striated
has troponin
t tubules
sr ca++
Term
cardiac is similar to smooth muscles-4
Definition
has pacemaker cells
gap junctions (syncytium)
Ca++ entry from outside
autonomic/hormones modulate
Term
DHPR and gain function in EC coupling
Definition
DHPR=Functional Ca++ receptor for Ca induced Ca release,
Gain function of 1:10
1 in from ECF and 10 out of SR.
Term
NCX- Role
And after Digitalis application?
Definition
NCX is a 3 Na/ 1 Ca exchange that restores ca++ to the SR myoplasm in "forward exchange" Relies on ATP for forward exchange
DIGITALIS blocks ATP. therefore Na accumulates and Ca goes INTO the cell (reverse)
Term
pacemaker cells
Definition
autorhythmic and determine HR
Term
cells responsible for rapidly spreading electrical stimulus throughout chambers.
FUNCTIONAL ROLE IN NORMAL HEARTBEAT
Definition
conducting cells
Term
99% of cells in heart.
MAIN ACTIVITY DETERMINES STROKE VOLUME
Definition
CONTRACTILE CELLS
Term
Conduction System Heartbeat coordination connections
SA Node
AV node
Bundle of His/purkinje;ventricle
Definition
connected via gap junctions
TRUE PACEMAKER GETS TO THRESHOLD FIRST
DELAYS SIGNAL, AP PROPAGATION IS SLOW
AP PROPAGATION IS FAST
Term
AV NODE
WHY SLOW AP PROP?
Definition
ONLY EXPECTED ELECTRICAL CONNECTION BETWEEN ATRIA AND VENTRICLE

SLOW AP PROPAGATION BECAUSE OF CHAINS OF CELLS AND ION CHANNEL DENSITY
Term
PATH OF ELECTRICAL FLOW (CONDUCTION0
1-7
Definition
SA NODE
ATRIAL MUSCLE CELLS
AV NODE
BUNDLE OF HIS- CONDUCTING CELLS
BUNDLE BRANCHES - CONDUCTING CELLS
PURKINJE FIBERS- CONDUCTING CELLS
VENTRICULAR MUSCLE CELLS
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