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Th differentiation
Lundy
4
Medical
Graduate
12/09/2012
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Term
Th1
 Definition
induced by Ag+IL12
produce IFN-gamma
act on intracellular pathogens
inhibited by IL4, IL10
Term
Th2
 Definition
induced by Ag+IL4
produce IL4, IL5, IL13
acts on worms and parasites
inhibited by IL12 and IL10
Term
Th17
 Definition
induced by Ag+TGF-beta, IL6, IL23
produce IL17, IL22, TNF-alpha, IL6
act on fungus or bacteria in blood, promoted autoimmunity
inhibited by IFN-gamma, IL4
Term
Treg
 Definition
induced by Ag+TGF-beta
produce IL10 and TGF-beta
act at mucosa
inhibited by TNF-alpha
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