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Test #4 Chapters 28-40
Lower Respiratory Agents
22
Pharmacology
Undergraduate 2
03/28/2011

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Cards

Term
COPD
Definition

-chronic obstructive pulmonary disease

-decreased forced expiratory volume

-chronic bronchitis, bronchiectasis, emphysema (irreversible); asthma (reversible)

Term
Alpha-1 & Beta 1&2 Adrenergic
Definition
Epinephrine, adrenalin, primatene mist, bronkaid mist side effects: tremors, tachycardia, dysrhythmias
Term
Beta-2 Adrenergic
Definition

-treat acute & chronic asthma, bronchitis, exercise-induced asthma

SE: tachycardia, palpitations, nervousness, tremors

-tolerance can develop

 

Examples: Albuterol (Proventil), Pributerol (MaxAir), Salmeterol (Serevent), Terbutaline (Brethine), Levabuterol (Xopenex)

Term
Terbutaline (Brethine)
Definition
-beta-2 adrenergic for pre-term labor
Term
Levabuterol (Xopenex)
Definition

-beta-2 adrenergic for asthma, bronchitis

-nebulizer; short acting

-active ingredient of Albuterol w/o SE

Term
*Metaproterenol (Alupent, Metaprel)
Definition

-beta-2 & some beta-1

-treat bronchosapsm & asthma

-beta-1 at high doses causes tremors tachycardia

-1 minute onset

-2-3 MDI inhalations, wait, then 2nd dose if needed

Term
Isoproterenol (Isuprel)
Definition

-non-selective beta-1 & beta-2 adrenergic

-tachycardia from beta-1

-not used often

Term
Ipratropium bromide (Atrovent)
Definition

 -anticholinergic for COPD

-caution w/ n-a glaucoma

Term
Ipratropium & albuterol (combivent)
Definition
-anticholinergic w/ fewer SE for chronic bronchitis
Term
Methylxanthine (Xanthine)
Definition
-bronchodilator for asthma
Term
Aminophylline (Theophylline)
Definition

-promotes bronchodilation

-narrow therapeutic range

-smoking increases metabolism of drug

-avoid other caffeine products

SE: convulsions, cardiac arrest

drug-drug: Tagamet, Dilantin

Term
Leukotriene
Definition

-causes inflammation

-mucus production

-not for acute asthma, for exercise-induced asthma

Examples: Singulair, Accolate, Zyflo

Term
*Montelukast (Singulair)
Definition

-leukotriene that prevents & maintains chronic asthma

-CI: status asthmaticus, severe asthma attack

-take during night for asthma, during day for allergies

Term
Zafirlukast (Accolate)
Definition
-reduces inflammation in bronchioles
Term
Zileuton (Zyflo)
Definition
-decreases inflammation & bronchoconstriction
Term
Glucocorticoids
Definition

-anti-inflammatory for refractory asthma

Examples: Vanceril, Aristocort, Decadron

Term
Beclomethasone (Vanceril)
Definition

-more effective for asthma control

-SE: hoarseness, throat irritation

-oral care important

Term
Triamcinolone (Aristocort)
Definition

-tablet for asthma

-SE: gastric irritation (take with food)

Term
Cromolyn (Intal)
Definition

-prevents asthma reaction

-not for an acute asthma attack

-SE: cough, bad taste (drink water before and after drug)

Term
Mucolytics
Definition
liquefy & loosen thick mucous secretions
Term
Acetylcysteine (Mucomyst)
Definition

-smells like rotten eggs

-use as antidote for acetaminophen (Tylenol) overdose

-mixed w/ water or juice

-nebulizer

-SE: stomatitis, rhinitis

Term
Nursing Measures for Lower Respiratory Agents
Definition

-monitor drug levels

-monitor VS, esp. resp.

-assess lips/fingernails for cyanosis

-assess breath sounds for wheezing, rale, rhonchi

-pulmonary PT: postural drainage, clapping

-hydration important

-medic-alert bracelet

-appropriate use of MDI and spacer

-observe for effectiveness of meds

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