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Test II; Pharm II
Pharm II study guide
61
Pharmacology
Undergraduate 4
10/22/2010

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Cards

Term
DOC for Thyroid Storm AKA: Thyrotoxicosis
Definition
Propylthiouracil
Term
Patient Education Thyroid Replacement
Definition
Taken on an empty stomach 30 min b/4 breakfast Routine Labs-CV status Side Affects: HA, insomnia, nervousness, tremors, tachycardia, angina, intensify effects of warfarin (blood thinner)
Term
Nsg Imp - Steroids
Definition
Inform females of voice change, acne, changes in body/facial hair, menstrual irregularities, signs of liver dysfunction (jaundice, malise, anorexia); teach about water retention (swelling of extremeties), unusual weight gain, warn women about becomming pregnant.
Term
USE - Vasopressin
Definition
Anti-diuretic hormone; therapeutic uses-diabetes insipidus, cardiac arrest, post-op abdominal distention, prep for abdominal radiography, bedwetting, hemophilia A, Von Willebrand's disease (bleeding disorder)
Term
MOA I131
Definition
Produces clinical remission with destruction of thyroid gland
Term
USE - Growth Hormone
Definition
Pediatric / adult growth hormone deficiency, pediatric non growth hormone-short stature, pediatric shhort stature associated with Prader-Willi syndrome (PWS), tx of non-healing fractures, AIDS wasting, panhypopiuitarism
Term
Nsg. Dx for patients taking Desmopressin
Definition
Risk for water intoxication r/t beginning desmopressin therapy
Term
Side Effects of LT Steroid Use
Definition
LT side effects-heart disease, diabetes, obesity, GERD, osteoporosis, myopathy, Cushing Syndrome Short-term SE-increased appetite, insomnia, changes in mood/behavior, flushing of the face, ST weight gain
Term
Patient Ed. Antihistamines
Definition
Can cause dry mouth, blurred vision, urinary retention, constipation, insomnia, tremors, sedation. Take with meals/snacks, do not opperate machinery (drousy), increase fluids, avoid alcohol, contraindicated-glaucoma, BPH, pregnancy, bladder neck obstruction and PUD.
Term
Benadryl - When to take the drug
Definition
1st generation; take in the pm; causes sedation effect; affective treating allergic disorders; can reduce sneezing, itching of the eyes, nose & throat.
Term
SE of Sympathomimetic drugs
Definition
Rebound congestion (worse than before), CNS stimulation, cardiovascular effects and stroke, potential for abuse
Term
Who should NOT take sympathomimetic drugs? Which are better-ORAL or TOPICAL?
Definition
Not recommended for children under the age of 4-there is no proof of efficacy or safety; there is proof of the potential for seriou harm. ORAL is better suited for LT use-because there is not rebound congestion.
Term
Assessment patient taking codiene and an antitussive for cough supression.
Definition
Codeine suppresses respiration; sometimes we want to suppress a cough and other times we do not; no good evidence says that antitussive tx is beneficial with the common cold
Term
MOA Guaifensin
Definition
Acts as expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. This may increase the efficiency of the cough reflex and facilitate removal of the secretions
Term
Ptnt education OTC meds for viral rhinitis
Definition
No treatment; can just treat the symptoms; use caution in children under the age of 2
Term
SE of 1st generation antihistamines
Definition
CNS depression; drowsiness, impaired thinking, dry mouth, dizziness. Less common are insomnia, nightmares, hallucinations, itchy skin
Term
Pt. teaching - Inhallers PLEASE READ INFORMATION IN BOOK-pg 904
Definition
How to use inhaller, use a spacer device, delivery can be inhanced by inhaling a SABA 5min. prior. Gargle after each administration, switch from oral to inhaled, must take supplemental clucocorticoids at times of severe stress, adequate calcium & Vit D intake to minimize bone loss, perform weight baring exercises
Term
Etiology of Thrush
Definition
Opportunistic infection. Candida found in oral cavity; most immune systems can control unless compermissed. LT enhaler use
Term
C&S-when to obtain and purpose
Definition
When there is a relapse/reinfection of UTI. Purpose is to determine the type of bacteria-we can then select the right treatment.
Term
Patient education-antibiotics
Definition
Take entire Rx, do not share, do not store "left-overs," taken @ evenly spaced intervals around the clock, know whether to take with food/H2O, if dose missed-do not double-up, report N/V, rash, diarrhea, signs of new infection, allergy, effectiveness of OC, drug/drug interactions (OTC)
Term
Definition of selective toxicity
Definition
Ability of the drug to injur target cell without hurting normal, healthy cells
Term
Vancomycin and Labs
Definition
Serum levels to determine peak levels/dosing appropriate. Labs drawn 1.5-2.5 hours after infusion
Term
Definition of broad spectrum antibiotics
Definition
Covers a wide range of microbes; covers gram (+) and gram (-)
Term
Definition of bacteriocidal
Definition
Directly kills bacteria/micro organisms
Term
Goal of antibiotic therapy
Definition
Want level of antibiotic to be at steady state; if drops down-the bacteria will further multiply
Term
Labs to determine Antibiotic therapy working
Definition
WBC; CBC with differential, serum drug levels (toxicity)
Term
Pyridoxine w/INH/TB drugs...why are they given together
Definition
INH depletes vitamin B6; therefore B6 replacement is taken to reduce neuropathy/numbness, tingling in the hands
Term
Reasons for tx failure with TB drugs
Definition
Cause severe side effects, symptoms resolve in a few weeks-do not have motivation to continue, tablets bulky, difficult to take on empty stomach,
Term
Meaning of resistance
Definition
At one time, may have been responsive to a particular drug and then becomes less susceptible to one or more of those drugs
Term
Patient assessment prior to antibiotic therapy
Definition
Allergy to Penicillin
Term
Side Effects of Aminoglycosides (Amikacin)
Definition
Nephrotoxicity, serious injury to the inner ear and kidney (ototoxicity), hypersensativity, blood dyscrasias, some type of paralysis. Check BUN/Cr. every AM
Term
Why do we pretreat with Amphotericin B
Definition
Mild reactions can be reduced. Include rigor, fever, chills, nausea and HA.
Term
Patient education for INH
Definition
SGOT & SGPT levels need to be monitored, Vitamin B6 to reverse symptoms of numbness/tingling or pain in the hands
Term
Expected outcome of pharmacotherapy and HIV
Definition
Lab value-Viral load is low and CD4 cell count is high
Term
Purpose of HAART
Definition
HIV "Highly active antiretroviral therapy" A strict protocl treatment with 3 drugs. Therapy has increased life expectancy to that of "normal"
Term
Best approach to tx of influenza
Definition
Influenza vaccine
Term
MOA pencillins
Definition
Weakens the bacterial cell wall causing the bacteria to take up excessive water and rupture. Only active against bacteria that are undergoing growth and division.
Term
Plan for desensitize a patient to an antibiotic
Definition
Careful supervision, small doses of antibiotic administered, if patient tolerates, the dose is slowly increased to the recommended dosage.
Term
Vancomycin and "Red Man Syndrome"
Definition
Red man syndrome caused by infusing vanc too rapidy. Flushing rash, pruritus, urticaria, tachycardia and hypotension. Result from the release of histamine-can be avoided by infusing slower (60 minuetes or more)
Term
Side effects of Tetracyclines
Definition
GI irritation, discoloration of teeth and bone, superinfection, hepatotoxicity, renal toxicity, photosensitivity
Term
Alternative drug to give to patient with penicillin allergy
Definition

Cephalosporin-if mild allergy

If allergy is severe - Eurythromycin

Term
Uses of sulfonamides
Definition
Primary use-uncomplicated UTI
Other uses-E-coli, chlamydia, ulcerative colitis
Term
UTI-Bacterium When should it not be given to a patient?
Definition
Patient is pregnant or lactating
Term
Side Effect of Rifampin
Definition
All body fluids are "pumpkin orange," interferes with OC, take on time with a full glass of H2O on an empty stomach
Term
Why multi drug therapy with TB
Definition
Resistance and reduce incidence of relapse
Term
Labs with INH
What to do if labs are abnormal
Definition
INH=Isoniazid
LABS-Liver Function Studies
SGOT & SGPT
Term
DOC for C-DIFF
Definition
Vancomycin (oral)
Term
Side Effects of levofloxacin
Definition
Tendon rupture/achilles tendon pain in the same class as DOC for anthrax
Term
Uses for Nystatin
Definition
Candidal infections (thrush), intestinal, skin, esophagus and vagina. Ptnts w/Cancer propholactically
Term
Patient education with TMP-SMZ
Definition
Complete course of treatment, report sore throat, fever, pallor-indicitative of severe blood disorder
Term
MOA of Valtrex
Definition
Tx of Herpes Simplex; inhibits viral replication by suppressing synthesis of viral DNA
Term
Patient education - Flu shots
Definition
Fever-defer, contraindicated for allergy to eggs, protection 1-2 after vaccination and lasts for 4-6m. Small risk for Gillain-Barre' Syndrome
Term
DOC for genital herpes
Definition
Acyclovir (Zovirax)
Term
DOC Syphilis
Definition
Penicillin G
Term
Patient education for family with pinworms
Definition
Entire family treated 1x pill; change bed linens, towels, undergarments daily, shower-don't take baths, good handwashing
Term
Epidemiology of head lice
Definition
Parasites live on surface of the host
Term
Patient education for scabies and the use of Elimite
Definition
AKA-Permethrin; can be liquid/cream. Adverse Affects: burning, stinging, itching, numbness, pain, rash, edema. Toxic to mites and ova; generally one application
Term
Aralen - DOC for what?
Definition
Many forms of Malaria High activity-erythrocytic forms Low activity-exoerythrocytic forms
Term
How to convert patient from oral to inhaled steroids
Definition
When converting, patients must receive an IV & increased dose of glucocorticoids during times of stress. Failure to do so-FATAL. Do for several months.
Term
Controller drugs - Abruptor drugs
When to use?
Definition
Term
Pyrazinamide & INH Tx together
Definition
INH is effective against actively dividing bacilli; pyrazinamide is active against intracellular bacilli. We increase the chances of killing all tubercle bacilli present-whether they are multiplying or dormant. Risk of relapse is lower
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