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Test 5 Pharm (ch. 48-51)
Drugs for Eye and Ear Disorders
59
Pharmacology
Undergraduate 2
04/15/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Diagnostic Aids for eyes
Definition

-Fluorecein sodium

 

-Fluorecin & benoxinate

 

-Rose Bengal

Term
Fluorecein sodium
Definition

-demonstrates defects in cornea

 

-scratches turn bright green, foreign bodies surrounded by green

 

-dye will appear in nasal lacrima if patent; yellow

Term
Fluorecein & benoxinate
Definition
-dye & local anesthetic; for removal of foreign bodies
Term
Rose Bengal
Definition
-preferred dye with superficial conjunctival tissue or corneal abrasion/foreign body suspected
Term
Topical anesthetics for eyes
Definition

-Proparacaine (Opthaine, Opthetic)

 

-Tetracaine (Pontocaine)

Term
Topical Anesthetics
Definition

-for removal of foregin bodies & portions of eye examination

 

-anesthesia achieved in 1 minute, lasts 15 minutes

 

-blink reflex lost temporarily; wisp test

 

-cornea does not remain moist; eye patch worn until med wears off

Term
Antiinfectives & Antiinflammatories (eyes)
Definition
-for eye infections (Conjunctivitis) - membrane covering eyeball & lining of eyelid
Term
Antiinfective/Antiinflammatory drugs (eyes)
Definition

-Cipro

-Garamycin

-Tobrex

-Silver nitrate 1%

-neomycin/polymixin B/bacitracin

-Natacyn

-Viroptic

-Vira-A

-cromolyn sodium (Crolom)

-ketotiden (Zatidor)

-olopatadine (Patanol)

Term
ciprofloxacin (Cipro)
Definition

-antibacterial for eyes

 

-conjunctivitis, corneal ulceration

 

-solution; 2 gtt q 15", x 6h, q 30", etc

Term
gentamycin (Garamycin)
Definition

-antibacterial for eyes

 

-infections of external eye

 

-solution & ointment

Term
Silver nitrate 1%
Definition

-antibacterial for eyes

 

-prevent & treat opthalmia neonatorum (in baby's eyes)

Term
Triple antibiotic (neomycin/polymixin B/bacitracin)
Definition

-antibacterial for eyes

 

-ointment

 

-effective against many gram - bacteria in eye

Term
tobramycin (Tobrex)
Definition

-antibacterial for eyes

 

-external ocular infections

 

-solution & ointment

Term
natamycin (Natacyn)
Definition

-antifungal for eyes

 

-solution

 

-may cause transcient stinging & burning

Term
trifluridine (Viroptic)
Definition

-antiviral for eyes

 

-for herpetic opthalmic infection

 

-1% solution; t gtt q 2h WA, 21 days tx

Term
vidarabine (Vira-A)
Definition

-antiviral for eyes

 

-for herpes keratitis & keratoconjunctivitis

 

-3% ointment; 5x/day

Term
cromolyin sodium (Crolom), ketotiden (Zaditor), olopatadine (Patanol)
Definition

-anti allergy for eyes

 

-SE: stinging, burning, headache

Term
Blepharitis
Definition
-inflammation of the margins of the eyelid
Term
Chalazion
Definition
-infection of meibomian glands of eyelid, causing cyst & blockage of ducts
Term
Endoopthalmitis
Definition
-inflammation of structures of the inner eye
Term
Antiglaucoma
Definition
-for IOP from excessive production or diminished outflow of aqueous humor
Term
Primary Glaucoma
Definition
-due to a pathologic change in the eye
Term
Secondary Glaucoma
Definition
- change due to systemic disease proccess & drugs
Term
Open Angle Glaucoma
Definition
-diminished outflow due to degenerative changes in trabecular meshwork
Term
Closed (narrow-angled) Glaucoma
Definition
-triggered by emotions & drugs that dilate pupils
Term
Cholinergics & anticholinesterase miotics
Definition

-lower IOP, increases blood flow to retina

 

-decreases loss of vision & retinal damage

 

-for open-angle glaucoma

Term
Direct-acting cholinergics
Definition

-similar to acetylcholine

 

-send nerve impulses to all cholinergic nerve sites

Term
*pilocarpine (Isopto Carpine)
Definition

-direct-acting cholinergic

 

-decreases IOP in glaucoma, induce miosis

 

-dose: 1-2 gtt tid-qid

 

-ointment used HS (at bedtime)

 

-Ocusert q 7 days (contact lens filled w/ med)

 

-SE: eye pain, blurry vision, headache, increased salivation & sweating

 

-adverse: HTN, SOB, tachycardia, bronchospasm, retinal detachment

 

-contraindicated: asthma, epilepsy, GI/GU obst.

 

-pressure on inner canthis to prevent systemic absorption

Term
carbachol (Isopto Carbachol)
Definition

-used if pilocarpine not effective

 

-1-2 gtt qd-qid

Term
Hordeolum
Definition
-local infection of eyelash follicles & glands on lid margins
Term
Keratitis
Definition
-corneal inflammation
Term
Ulveitis
Definition
-infection of vascular layer of eye (choroid, iris, ciliary body)
Term
Lubricants for eyes
Definition

-alleviate dryness, during surgery, CNS disorders with excessive blinking

 

-liquid ointments

 

example drugs: Isopto Tears, Tearisol, Tears Naturale, Lacri-lube

-can have reaction to preservative

 

Term
Indirect-acting cholinergics
Definition

-inactive cholinesterase, inhibit destruction of acetylcholine

 

-cause pupil constriction & ciliary muscle contraction

 

-example drugs: Isopto Eserin, Humorsol

 

Term
physostigmine salicylate (Isopto Eserine)
Definition

-treats wide-angle glaucoma

 

-short-acting

 

-ointment & solution used 3-4x/day

Term
demecarium bromide (Humorsol)
Definition

-treats open-angle glaucoma

 

-1-2 gtt bid

Term
betaxolol (Betoptic)
Definition

-beta-blocker

 

-decrease IOP in chronic o-a glaucoma & ocular HTN

 

-not for asthma patients

 

-caution w/ oral beta-blockers

 

-1 gtt bid

Term
carteolol (Ocupress)
Definition

-beta-blocker

 

-open-angle glaucoma

 

-caution w/ oral b-b

 

-1 gtt bid

Term
timolol (Timoptic)
Definition

-beta-blocker

 

-reduces production of aqueous humor

 

-monitor VS

 

-blurred vision improves w/ time

Term
Beta-blockers for eye
Definition

-Betoptic

-Ocupress

-Timoptic

-levobunolol (Betagan)

-levobetaxolol (Betaxon)

Term
Prostaglandin Analoques
Definition

-as effective as b-b with fewer side effects

 

-SE: brown pigmentation in green-brown or yellow-brown irises; permanent

 

-blurred vision, ocular hyperemia, dry eye, tearing, light intolerance

 

example drugs: latanoprost (Xalatan), bimatoprost (Lumigan), Travatan, unoprostone (Rescula)

Term
travoprost (Travatan)
Definition

-prostaglandin analoque

 

-increases uveoscleral outflow, more effective in AA (African Americans) than non-AA

 

-1 gtt at HS

Term
Carbonic anhydrase inhibitors
Definition

-decrease aqueous humor

 

-for o-a glaucoma

 

-used if other agents are not effective

 

-SE: anorexia, lethargy, depression, hypokalemia, parathesia

 

-caution: do not use if allergy to SULFA or pregnant

 

-example drugs: Diamox, Azopt, timolol/dorzolamide 0.5%/0.2%, Trusopt

Term
Osmotics for eyes
Definition

-used pre- & post-operatively to decrease vitreous humor volume, reducing IOP

 

-for emergency tx of acute closed-angle glaucoma

 

-SE: headache, n/v/d, disorientation

 

-example drugs: Osmitrol, isorsorbide (Ismotic), glycerin

Term
mannitol (Osmitrol)
Definition

-osmotic for eyes

 

-IV solution 15-20%

 

-1.5-2g/kg over 30-60 mins

Term
Anticholinergic mydriatics & cycloplegics
Definition

-dilate & paralyze muscles of accomidation

 

-used during eye surgery

 

-SE: brow pain, worsening n-a glaucoma (mydriatics), tachycardia, dry mouth, atropine-toxicity (treat with phyostigmine)

 

-example drugs: Atropsilol, Mydriacyl, Epinal

Term
atropine sulfate (Atropsilol)
Definition

-cycloplegic for refraction

 

-1-2 gtt up to qid

Term
tropicamide (Mydriacyl)
Definition

-mydriatic

 

-dilate/anesthesize for eye exam

Term
epinethrine (Epinal)
Definition
-for eye surgery & o-a glaucoma
Term
Macular degeneration
Definition

-blurs central vision, dark spot(s) in eye

 

-age related (ARMD)

 

-Wet, dry types

 

-laser tx., photodynamic tx, meds

 

-example drugs: Macugen, Lucentis

Term
WET Macular Degeneration
Definition

-progresses rapidly; growth of blood vessels behind retina

 

-10-15% of cases

Term
DRY Macular Degeneration
Definition

-progresses slowly over years; gradual destruction of light-sensitive cells in macula

 

-85-90% of cases

Term
pegaptanib (Macugen)
Definition
-eye injectable for macular degeneration (ARMD)
Term
ranibizumab (Lucentis)
Definition
-eye injection every month for macular degeneration (ARMD)
Term
Antibacterials for ear
Definition
-external: tetracycline (Acromycin), chloramphenical (chloromycetin)-infection of ear canal
Term
Antibacterials for ear
Definition
-internal - amoxicillin (Amoxil)-tx of otitis media, cefaclor (Ceclor), Bactrim, Augmentin
Term
Antihistamine & Decongestants for ears
Definition

-reduce middle ear & nasal congestion in acute OM

 

-example drugs: Dimetapp, Dimetane, Triaminic

Term
Irrigation of ear
Definition
-inject warm water up in ear
Term
Cerumen
Definition

- ear wax

 

-example drugs: debrox, Ear-Dry, Cerumenex (OTC)-soften & remove impacted ear wax

 

-Cerumenex - low strength peroxide

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