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Test 4 Pathophysiology Alterations of Renal/urinary Function
Test 4 Pathophysiology Alterations of Renal/urinary Function
46
Medical
Graduate
04/28/2015

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Term
Name four potential culprits for urinary tract obstruction
Definition
1. prostate hypertrophy
2. fibrous band
3. tumor
4. stricture
Term
hydropnephrosis involve urine backing up into what structures of the kidney
Definition
renal pelvis and major/minor calyxes
Term
Uncorrected hydronephrosis results in
Definition
tubulointerstitial fibrosis and apoptosis
Term
Describe tubulointerstitial fibrosis
Definition
irreversible, excess collagen deposits from untreated urinary tract obstruction. Happens in days.
Term
which gender has higher risks for kidney stones
Definition
1. MEN
2. race
3. tropical areas
4. fluid intake
5. occupation
Term
kidney stones are comprised of
Definition
1. phosphate
or
2. uric acid
Term
describe renal colic pain
Definition
1. moderate to intense pain
2. intense peak and then gradual decline
Term
how can you remove a stone
Definition
cytoscope or lithotripsy
Term
what is bladder neck dyssynergia
Definition
Dyssynergia is any disturbance of smooth muscular coordination, resulting in uncoordinated and abrupt movements. In bladder neck dyssynergia the bladder contractions do not form a funnel during micturition
Term
severe pelvic organ prolapse is most common in what gender
Definition
females that are older
Term
Neurogenic detrusor overactivity results in
Definition
urgency
Term
what neuromuscular disease can lead to detrusor sphincter dyssynergia
Definition
guilian barre. Causes a discoordination between the detrusor muscle and sphincter.
Term
is a renal adenoma benign or malignant
Definition
benign
Term
a persistent UTI sx continue for greater than > __ days
Definition
> 3 days
Term
inflammation of the bladder is called
Definition
cystitis
Term
definition for CHRONIC pyelonephritis
Definition
Persistent and recurring episodes of acute pyelonephritis that leads to a SHRUNKEN, FIBROTIC kidney
Term
urinary sediment can change and have what three things in ir
Definition
1. proteinuria
2. hematuria
3. lipidurea
Term
what is the difference between nephrotic and nephritic sediment
Definition
Nephrotic Sediment= protein only in urine
Nephritic Sediment = protein + Blood in urine
Term
Which has more protein and hematuria, nephrotic/nephritic or chronic glomerular diseae
Definition
nephritic/nephrotic > PROTEIN/Blood in sediment than Chronic glomeruluar disease
Term
glomerular disease sx
Definition
sudden or insiduous onset of HTN, EDEMA, ELevated BUN
Term
most common culprit of glomerulonephritis
Definition
immunologic abnormalities
Term
list some viral causes of glomerulonephritis
Definition
1. mumps
2. strep in kids
3. PNA
4. HIV
5. Hepatitis
6. Lupus
7. unk
Term
when would acute post-strep glomerulonephritis occur
Definition
7-10 days after group strep A in kids
Term
Explain IgA nephropathy
Definition
viral URI or GI. The activated IgA and complement not only attacks pathogen but also binds to mesangial cells which cause them to prliferate and be injuries resulting in glomeerulonephritis
Term
which kind of glomerulonephritis is rapidly progressing and lesion like on the bowman's capsule
Definition
crescentic glomerulonephritis
Term
Ab formation against pulmonary capillaries and glomerular basement membrane is called
Definition
goodpasture syndrome (anti-glomerular basement membrane disease)
Term
What is the mechanism of injury for chronic glomerulonephritis
Definition
1. deposits of soluble Ag-Ab
2. formation of Ab against basement membrane
3. loss of negative charge and breakdown of podocytes
4. streptococcal release of neuramidase
Term
nephrotic syndrome invovles the excretion of _ gram per day
Definition
3.5 g/day
Term
what is the treatment for nephrotic syndrome
Definition
so this syndorme looses tons of protien so you want to treat teh s/e which is edema with diuretics and maitnain a normal protein diet.
Term
most common cause of AKI
Definition
pre-renal due to hypovolemia, low CO,
Term
Which type of acute kidney injury will not improve with adequate volume of perfusion
Definition
intrinsic renal injury
Term
most common cause of intrarenal kidney injury
Definition
ATN Acute tubular necrosis
Term
What are the two sub-types of ATN
Definition

1. postischemic

2. nephrotoxic; from drug injuries, excess myoglobin, contrast, some anesthessia. So things that we given or have done to our body which are unrelated to direct supply/demand

Term
what is normal urine specific gravity
Definition
1.003 - 1.030
Term
what is the difference in urine specific gravity between pre-renal and intrarenal failure
Definition
normal Specific gravity = 1.003-1.030
Pre-renal: Low BP means no plasma for kidneys to pee out so SG is high. 1.016-1.020
Intrarenal: Low and fixed at 1.010 -1.012
Term
The osmolarity of the urine between prerenal and intrarenal
Definition
prerenal: HIGH >500 mOsm
Intrarenal: Low <300 mOsm
Term
what is the difference between the BUN:Cr ratio of pre-renal and intrarenal
Definition

prerenal: >15:1 cause BUN rises

 

Intrarenal: <15:1 BUN & Cr fall together. Meaning Cr rises and is a higher in comparison to BUN. So like 30:2.5 

Term
What's the difference between urine Na in prerenal and intrarenal
Definition
pre-renal: <10 mEq/l body is hypovolumic so holds onto Na.

Intra-renal: >30 mEq/l kidney has issues
Term
What's the difference between FE-Na in prerenal and intrarenal
Definition
pre-renal: <1%
Intra-renal >1%
Term
does intra=renal or prerenal have urine sediment
Definition
intra=renal
Term
what stage of CKD will you have sx
Definition
stage 3 or higher
Term
end stage renal failure is CKD stage
Definition
CKD stage 5
Term
there is a metabolic acidosis when the GFR decreases ___%
Definition
GFR decrease of 30-40%
Term
why do bad CKD patients have encephalopathy
Definition
from build up of nitrogenous waste. High seizure risk!
Term
What happens to WBC and platelets in CKD patients
Definition
Decrase WBC and deformed platelets
Term
uremic frost on pt skin is associated with what disease
Definition
CKD
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