Term
| definition for auto-immunity |
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Definition
| when an immune response is against self instead of what should happen which is normal self tolerance. |
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Term
| Autoimmunity done via what two processes of immune system 2x |
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Definition
| 1. auto-Ab autoimmunity 2. T cell mediated autoimmunity |
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Term
| Paul Ehrlich believed what in regards to autoimmunity |
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Definition
| that our immune system doesn't attack self because it has a tolerance to the Ag associated with our normal cells. |
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Term
| Are all autoimmune responses harmful? IF not name some that aren't |
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Definition
| Not all autoimmune responses are harmful. Immune system can be helpful in removing damaged self cells |
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Term
| so if a healthy immune system means that the immune system is tolerating the body's self cells than describe types of tolerance 2x |
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Definition
1. Central tolerance
2. Peripheral Tolerance |
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Term
| abnormal autoimmune responses can be categorized by what two causes |
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Definition
1. primary cause
2. secondary contributor |
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Term
| there are no autoimmune diseases that correlate with which type of hypersensitivity? |
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Definition
| Type I IgE mediated hypersensitivities |
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Term
| can autoimmune diseases overlap |
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Definition
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Term
| the autoimmune anemias occur as a result of what immune resposne |
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Definition
auto-Ab.
Autoimmune hemolytic anemia is a result of Auto-Ab attacking drugs or drug-RBC complexes
2. Pernicious Anemia is Auto-Ab attacking parietal cells. IF no parital cells than no production of Intrinsic facto. Need intrinsic factor for B 12 absoprtion and hematopiesis |
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Term
| IFN-Gamma can induce MHC Class ___ on what cells 3x |
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Definition
1. pancreatic Beta cells (IDDM)
2. Intestinal epithelial cells
3. THyroid Acinar Cells (Graves disease) |
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Term
| what auto-Ab can cross the placenta |
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Definition
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Term
| how do you offset the effects of auto-Ab in new borns from moms |
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Definition
| plasmapheresis. Give a complete blood exchange to eliminate the effects of auto-Ab. |
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Term
| what type of autoimmune disease cannot cross the fetus |
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Definition
| TH cells or Tc cells are impossible to cross into fetal circulation |
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Term
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Definition
| disorder of the small intestine, Ab attack gliadins and tissue transaminases which come from wheat, barley and rye. |
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