Term
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Definition
| used in glycolysis for the production of ATP |
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Term
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Definition
| high glucose levels result in the ______ of the enzyme adenylate cyclase |
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Term
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Definition
| inactive adenylate cyclase + low cAMP levels |
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Term
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Definition
| active adenylate cyclase + high cAMP levels |
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Term
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Definition
| act on promoters that are poorly recognized by RNA polymerase |
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Term
| High cAMP levels (low glucose) |
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Definition
cAMP binds to CAP protein
RNA polymerase biding to promoter is stimulated
transcription is activated |
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Term
| Low cAMP levels (high glucose) |
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Definition
no cAMP bound to CAP
no/poor RNA polymerase binding to promoter
no transcription |
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Term
The RNA polymerase binding sites (-10 and -35 sites)
A CAP binding site (an activator)
An operator sequence recognized by the lac repressor |
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Definition
| 3 distinct DNA binding sites on the lac promoter region |
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Term
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Definition
| the lac operon codes for proteins involved in the uptake and breakdown of the sugar _________ |
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Term
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Definition
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Term
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Definition
Operon off
Lac repressor bound
CAP not bound |
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Term
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Definition
Operon off
Lac repressor bound |
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Term
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Definition
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Term
1. CAP proteins that binds to DNA
2. Lactose converting into allolactose by the cell which inhbits DNA binding activity
3. lac repressor binds to DNA blocking RNA polymerase |
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Definition
| 3 signals that control the lac operon |
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Term
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Definition
| proteins that bind to specific DNA sequences called Enhancer sites |
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Term
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Definition
| regulatory DNA sequence to which transcription regulators bind, influencing the rate of transcription of a structural gene that can be many thousands of base pairs away |
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Term
| By recruiting general transcription factors and RNA polymerase II to a promoter |
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Definition
| How can a proteins that binds at a location far from the transcriptional site influence transcriptional initiation? |
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Term
1. DNA between the enhancer and promoter sites 'loop out'
2. A mediator complex |
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Definition
| 2 requirements of Activator proteins recruitment |
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