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Test 2 - Pharm Benzos
Benzsos
47
Nursing
Graduate
10/14/2013
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Term
Droperidol Dose Premed Sedation.
 Definition
2.5 to 10mg
Term
Droperidol Dose Antiemetic
 Definition
0.625 mg.
Term
Droperidol Onset.
 Definition
3 to 10 minutes.
Term
Droperidol Duration.
 Definition
2 to 4 hours.
Term
Midazolam Concentration.
 Definition
1mg and 5mg per ml vials.
Term
Midazolam Dose Induction.
 Definition
0.1 to 0.2 mg/kg (or more).
Term
Midazolam Dose Sedation.
 Definition
0.5 to 5 mg titrated. 0.025 to 0.1mg/kg.
Term
Midazolam Dose Seizures.
 Definition
2 to 5mg
Term
Midazolam Dose Infusion.
 Definition
0.25 to 5.0 mcg/kg/min.
Term
Midazolam Onset.
 Definition
Less than 60 seconds.
Term
Midazolam Peak
 Definition
3 to 5 minutes.
Term
Midazolam Duration
 Definition
15 to 80 minutes. Less active metabolites than diazepam there for shorter duration.
Term
Midazolam Strength.
 Definition
2 to 3 times as strong as diazepam, with shorter duration.
Term
Midazolam Protein Binding.
 Definition
High.
Term
Midazolam Metabolism.
 Definition
Hepatic C-P450. 10x greater than diazepam. Shorter duration. 50% bioavailability after rapid GI absorbtion.
Term
Midazolam Excretion.
 Definition
Kidney.
Term
Midazolam Elimination 1/2 time.
 Definition
1-4 hours.
Term
Diazepam Dose Induction.
 Definition
0.3 to 0.5 mg/kg (or more).
Term
Diazepam Dose Sedation.
 Definition
0.05 to 0.2 mg/kg (2-10mg).
Term
Diazepam Dose Seizures
 Definition
5 to 10mg IV.
Term
Diazepam Onset.
 Definition
Less than 2 minutes.
Term
Diazepam Peak
 Definition
3 to 4 minutes.
Term
Diazepam Duration
 Definition
15 to 60 minutes. Can linger due to active metabolites.
Term
Diazepam Protein Binding.
 Definition
Very high. 98%.
Term
Diazepam Metabolism.
 Definition

Hepatic via N-demethylation.

CP450.

 
Term
Diazepam Excretion.
 Definition
Kidney.
Term
Diazepam Elimination 1/2 time.
 Definition
20 to 37 hours. Prolonged in liver cirrhosis and in elderly.
Term
Diazepam Elimination 1/2 time of metabolites.
 Definition
48 to 96 hours.
Term
Lorazepam Dose.
 Definition
0.5 to 1mg.
Term
Lorazepam Onset.
 Definition
1 to 5 minutes.
Term
Lorazepam Peak
 Definition
15 to 20 minutes.
Term
Lorazepam Duration
 Definition
6 to 10 hours.
Term
Lorazepam Strength.
 Definition
Approximately 6x Diazepam.
Term
Lorazepam Protein Binding.
 Definition
High.
Term
Lorazepam Metabolism.
 Definition

CP450.

Conjugated to inactive metabolites
Term
Lorazepam Elimination 1/2 time.
 Definition
10 to 20 hours.
Term
Flumazenil Concentration.
 Definition
.1mg per ml.
Term
Flumazenil Dose.
 Definition
0.2 to 1.0 mg (4 to 20 mcg/kg) Slowly.
Term
Flumazenil Dose Infusion.
 Definition
30 to 60 mcg/min up to 3mg hour.
Term
Flumazenil Dose Trach.
 Definition
Dilute 1mg/10ml.
Term
Flumazenil Onset.
 Definition
1 to 2 minutes.
Term
Flumazenil Peak
 Definition
2 to 10 minutes.
Term
Flumazenil Duration
 Definition
45 to 90 minutes. Varies based upon plasma concentration of Benzo.
Term
Flumazenil Protein Binding.
 Definition
High.
Term
Flumazenil Lipid Solubility.
 Definition
Less Lipid soluble than diazepam.
Term
Flumazenil Metabolism.
 Definition
Conjugated to inactive metabolites
Term
Flumazenil Elimination 1/2 time.
 Definition
10 to 20 hours.
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