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Test 2 Pharm and Physiology for Anesthesia
Cholinergic Agonist and Antagonist
23
Pharmacology
Graduate
10/18/2014

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Cards

Term
what receptors do atropine and scop block?
Definition
M receptors
Term
you pair atropine with what AcHe Inhibitor
Definition
Atropine goes with edrophonium
Term
glycopyrrolate pairs with what two drugs?
Definition
1. neostigmine
2. pyridostignmine
Term
with large doses of anticholinergics what sx occur
Definition
inhibits micturition, gastric Hydrogen ion secretion and gut motility.
Term
adult dose of atropine in the OR is?
Definition
0.4mg IV. For a code its 1mg. do no exceed 3mg.
Term
pedi dose for atropine is?
Definition
10-20 mcg/kg
Term
describe atropine
Definition
half life of 2-4 hours, can cross BBB, high doses can cause CNS effects such as restlessness, delirium, coma, renal excretion,
Term
IM Atropine dose adult? Pedi?
Definition
adult 1-2mg
pedi 20-40mcg kg
Term
does atropine increase or decrease baroreflex? explain
Definition
it decreases, b/c since atropine increases your HR it also increases your blood pressure. The baroreflex normally regulates this by decreasing your HR when it senses increase BP. So atropine disables this
Term
Does atropine cross the placenta
Definition
yes
Term
why does atropine increase your risk for emesis?
Definition
it lowers the tone to your lower esophageal sphincter tone
Term
which is more sedating atropine or scop
Definition
scop. so dont give to elderly
Term
which is ok to give to pt with glaucoma
Definition
atropine
Term
overdose of atropine or scop will result in these sx
Definition
1. dilated pupils
2. dry mucosa
3. dry flushed skin
4. head ache
5. increased HR
6. blurred vision
7. ataxia
8. restlessness
9. coma
Term
what drug can you give to treat an anticholinergic overdose. What dose?
Definition
physostigmine b/c it can cross the BBB, 1mg IV. Benzo for seizures, ventilator support if needed.
Term
what is central anticholinergic syndrome? trt with?
Definition
similar to atropine overdose except pt is motionless and depression is set in. decrease resp drive, treat with physostigmine 1mg IV
Term
whats the mneumonic for anticholinergic toxicity
Definition
ANTICHOLINERGIC TOXICITY FROM ATROPINE: blind as a bat, mad as a hatter, red as a beat, hot as hades, dry as a bone, bowel and bladder loose their tone, and the heart runs alone.
Term
whats the conc of neo + gly.
Definition
for every 1mg of neostig given 0.2 glyc
Term
Which anticholinergic is most likely to cause emesis..why
Definition
glyc, can cause b/c it decreases the lower esophageal tone.
Term
name a anticholinergic drug used for parkinsonianism
Definition
cogentin
Term
meperidine and benadryl share what in common?
Definition
both are antimuscarinic. (hence the CNS since they also act centrally)
Term
what is cogentin used for?
Definition
It is an anticholinergic used for alzheimers, treats also extrapyrimidial side effects from reglan or other antipsychotics
Term
how does atropine and scop effect the resp
Definition
bronchodilation, decreases airway resistance and blunts the hyperresponsiveness of respt tracts, also decrease mucous secretion
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