Proton Pump Inhibitor

Tx: Ulcers, Zollinger-Ellison

Contra: Liver dx

Sfx: Hypergastrinemia (trophic factor, possible tumor growth), decrease B12 absorption

H2 receptor antagonist (reduce gastric secretions)

-70% of acid secretion through this pathway

-Most effective against nocturnal acid sxn

*Gynecomastia and impotence (from displacement of DHtestosterone from binding sites/inhibits estrogen metab @ P450)

PGE1 analog

-primary effect is binding IP₃ and inhibiting acid sxn

-Stimulates sxn of mucin and bicarb

Sfx: Abortion*

Tx: Prevention of injury due to NSAIDs (replacement of PG)

GI prokinetic (D₂-Receptor Antagonist)

Enhances ACh release by antag inhib of Dopamine on Cholinergic nerves (also inhibits CTZ)

Tx: Gastroparesis, Nausea and Vomiting

Prokinetic (D₂ receptor antag/5HT3 receptor antag/5HT4 agonist)

-Increase tone of lower esophageal sphincter

-Stimulates antral and SI contractions (emptying)

**Tardive Dyskinesia

-Blocks D2 receptors in CTZ (stops N/V)

H1 antagonist (anti-emetic)

-Good for motion sickness

5-HT₃ antagonist (Anti-Emitic)

-Blocks serotonin in CTZ

Tx: N&V of Chemo, radiation, Post op

Synthetic THC (Anti-emetic)

-Appetite stim in AIDs and N&V

*Central Sympathomimetic and can get abstinence synd

Anti-diarrheal (pepto-bismol)

-Thought to be antisecretory, anti-inflammatory, and antibacterial

Anti-diarrheal opioid (mu-R agonist)

-50x more potent that morphine (little CNS activity)

Contra: IBD

Laxative (increase fluid secretion)

-by inducing inflammation

*Can get lazy bowel syndrome and get into breast milk

Laxative (increase fluid secretion)

5-ASA for IBD

Inhibits COX and LOX

-Sulfapyridine has lots of Sfx:

Megaloblastic anemia (dec folate abs)

Stevens-Johnsons, Pancreatitis, Neurotoxicity

5-ASA (inhibits COX and LOX)

-Not the side-effect profile of sulfasalazine

-Better against Crohns

Has Azo bond (broken down by bacteria) []'s in colon