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Test 1 - Developmental Microanatomy
Donnell's embryology notes
106
Histology
Professional
09/20/2011

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Term
Zygote
Definition
pleuripotent diploid cell formed by pronuclei fusion
Term
Upon fusion:
Definition
mitosis and cleaeage initiate to form a 2-cell zygote.
Term
A morula is a zygote at the ___ cell stage that is composed of _____ that will differentiate.
Definition
16-32; blastomeres
Term
Inner Blastomeres
Definition
undergo compaction to an adherent ball of cells AKA inner cell mass
Term
Inner Blastomeres
Definition
develop gap junctions for cell signalling
Term
Inner Blastomeres
Definition
will become the embryo
Term
Surface (Outer) Blastomeres
Definition
flatten to form trophoblasts with tight junctions
Term
Outer Blastomeres
Definition
will form the chorionic and amniotic portions of the placenta
Term
After reaching ___ cells, the morula deveopts a fluid-filled space called a _____. The conceptus is then called a _____.
Definition
128; blastocoel; blasocyst
Term
As it accumulates fluid, the blastocyst expands. The surface blastomeres (also called _____) secrete a protease that _____ and allows the blastocyst to _____.
Definition
trophoblasts; lyses the zona; "hatch"
Term
After "hatching," the blasocysts can now _____ and _____ via adhesion molecules.
Definition
contact the uterine surface; anchor itself
Term
Epiblasts
Definition
form the embryo proper
Term
Hypoblasts
Definition
form the yolk sack
Term
On the epiblast surface, a _____ forms as differential cell growth generates a pair of ridges separated by a depression.
Definition
primitive streak
Term
The primitive streak defines the _____ acis of the embryo.
Definition
longitudinal
Term
Below the primitive streak a space forms between the _____ and the _____; this will become coelom (_____)
Definition
hypoblasts; epiblasts; body cavity
Term
The embryoblast now undergoes a stage called _____.
Definition
gastrulation
Term
Gastrulation
Definition
process that gives rise to three germ layers
Term
Ectoderm
Definition
will give rise to the epidermies & nervous system
Term
Ectoderm
Definition
neutral tube & embryonic surface cells
Term
mesoderm
Definition
paraxial, intermediate, lateral plate
Term
Endoderm
Definition
lining primitive gut & notocord
Term
Endoderm
Definition
will give rise to the lining of the gut, lower respiratory tract and smoe internal organs (pancreas)
Term
Mesoderm
Definition
will give rise to bone, cartilage, muscle, dermis, connective tissues, vessel and most of the urogenital tract
Term
As the gastrula elongates, the embryo goes from a _____ to a more _____ form with initial differentiation.
Definition
solid disk; tubular
Term
Notocord
Definition
solid rod of cells that forms when a furrow in the dorsal epiblasts folds & merges
Term
Notochord
Definition
present in all vertebrates during embryogenesis
Term
The mesoderm is subdivided into ___ columns of cells.
Definition
three
Term
Paraxial Mesodermal Column
Definition
spinal & vertebral column
Term
Intermediate Mesodernal Column
Definition
kidneys, some reproductive tract
Term
Lateral Mesodermal Column
Definition
splanchnic vessels, heart, walls of gut, parts of body wall
Term
Paraxial Mesodermal Column
Definition
develops transverse fissures that separate the column into somites
Term
Each somite formed from the paraxial mesoderm will give rise to the:
Definition
sclerotome (axial skeleton), myotome (body wall, muscular), dermatome (dermis)
Term
Neurulation
Definition
formation of the neural tube
Term
Basal Plate of Neural Tube
Definition
produces motor neurons
Term
Alar Plat of Neural Tube
Definition
produces inter neurons
Term
Folding of the neural plate occures in the _____ to _____ direction.
Definition
cranial; caudal
Term
The anteior neural tube balloons into ___ primary vesicles.
Definition
three: forebrain, midbrain, hindbrain
Term
Prosencephalon
Definition
forebrain
Term
Mesencephalon
Definition
midbrain
Term
Rhombencephalon
Definition
hindbrain
Term
Prosencephalon becomes:
Definition
telencephalon, diencephalons, optic cup
Term
Telencephalon
Definition
cerebral hemispheres
Term
Diencephalons
Definition
thalamic & hypothalamic optic centers
Term
Optic Cup
Definition
exdends from diencephalons
Term
Mesencephalon becomes:
Definition
mesencephalic aqueduct (cerebrospinal fluid)
Term
Prhombencephalon becomes:
Definition
metencephalon, myelencephalon
Term
Metencephalon
Definition
cerebellum
Term
Myelencephalon
Definition
medulla oblongata
Term
Most of the face, jaws and dorsal skull develop from _____.
Definition
ectodermal neural crest cells
Term
Stomadeum
Definition
primordial cell masses that form around a central area of depression of the ectoderm at the ventral aspect of the anterior end of the embryo
Term
The first pharyngeal arch forms _____.
Definition
the wall and base (maxilla & mandible) of the stomadeum
Term
The remainder of the pharyngeal arches form _____.
Definition
portions of the neck and cranial medistinum.
Term
Heart
Definition
one of the first organs to develop
Term
Initially, a paired tube of _____ cells with a _____ to _____ orientation; at the side of the heart, the tubes _____.
Definition
endothelial; cranial to caudal; fuse
Term
The heart tube undergoes an __-shaped looping to change from _____ polarity to _____ polarity.
Definition
"S"; anterior/posterior; left/right
Term
Formation of the GI tract begins with _____ that includes the _____ which initially remains outside of the embryo.
Definition
folding of the endoderm; yolk sac
Term
Endoderm
Definition
becomes epithelial lining
Term
Splanchnic Mesoderm
Definition
wall of gut & mesentery
Term
Ectoderm
Definition
serosa
Term
As the GI tract develops, it _____ and ______.
Definition
twists; elongates
Term
The GI tract is rougly divided into ___ area.
Definition
three: foregut, midgut, hindgut
Term
Foregut
Definition
develops first; parts of mouth, lower respiratory system, esophagus,stomach, duodenum, pancreas, liver, gallbladder
Term
Midgut
Definition
duodenum, jejunum, ileum, cecum, proximal colon
Term
Hindgut
Definition
cloaca: urinary tract & rectum
Term
The urogenital system is the _____ organ system to develop.
Definition
last
Term
Kidney is composed of two elements responsible for _____ & ______.
Definition
filtration (glomeruli); transport (tubules & ducts)
Term
Three developemental kidney stages:
Definition
pronephros (first kidney); mesonephros (middle kidney); metanephros (later kidney)
Term
The extremities start as _____ that consist of a core of _____ and an outer covering of _____ cells.
Definition
limb buds; mesoderm; ectodermal
Term
The _____ limb buds arise first, a few days before the _____ limb buds.
Definition
cranial; distal
Term
Initially the entire limb skeleton is _____.
Definition
cartilaginous
Term
Initially the lumb buds extend _____. Site of the first digit oriented _____. The limbs shift into a more _____ position, then rotate approximately _____ degrees.
Definition
laterally; cranially; ventral; 90
Term
Ectoderm
Definition
surface epithelium (skin, hair follices)
neural plate (spinal cord, brain)
neural crest cells (facial region, ganglia)
Term
Mesoderm
Definition
somites (sclerotomes (skeleton), myotomes (skeletal muscle), dermatomes (dermis), intermediate plate (kidneys, genital tract))
lateral plate (limbs, heart, spleen, mesentery, GI walls, allantois, marrow)
Term
Endoderm
Definition
notochord (vertebral disc)
gut (GI epithelium, liver, pancreas)
Term
Placenta
Definition
transfers gasses, nutrients & wastes between embryo & mother; embryonic/fetal protection
Term
Chorion
Definition
from trophoblasts which are determined at the morula stage
Term
Amnion
Definition
from the epiblasts which are determined at the blastula stage
Term
Yolk Sac
Definition
from the hypoblasts which are determined at the blastula stage
Term
Allantois
Definition
from lateral plate mesoderm of the hind gut at gastrula stage
Term
Umbilicus
Definition
develops at the same time as allantois from hind gut
Term
Chorioallantois
Definition
chorion and allantois (fuse in mammals)
Term
Chorion
Definition
contact cell layer with uterus at fetal/maternal exchange
Term
Allantois
Definition
physical support of chorionic layer and vascular bed for transport of nutrients, gas and waste
Term
Amnion
Definition
contains amniotic fluid which is protective and ocntains excreted urine
Term
Yolk Sac
Definition
regresses and is of minimal importance in mammals
Term
Umbilical Cord
Definition
moves blood between the embryo/fetus and chorioallantoic membrane
Term
Amnion
Definition
simple layer of epithelium held by tight junctions (no nerves, CT or vessels)
Term
chorioallantois
Definition
layer of epithelial type cells suppored by membrane matrix of collagen, mucopolysaccharides, hyaluronic acid
Term
Umbilical Cord
Definition
two arteries & one vein with a loose mesenchyme of proteoglycans, collagen and myofibroblasts (Wharton's jelly)
Term
Amniotic Sac
Definition
clear to light yellow, watery fluid; thin clear membrane; no vessels
Term
Umbilicus
Definition
twisted cord
Term
There are potentially _____ layers of tissue separating maternal & fetal blood.
Definition
six
Term
Three layers in the chorioallantoic placenta:
Definition
(1) endothelium of allantoic capillaries
(2) CT of chorioallantoic mesoderm
(3) chorionic epithelium
Term
Three lyaers on maternal side of placenta:
Definition
(1) endometrial epithelium
(2) CT of endometrium
(3) endothelium of endometrial capillaries
Term
There are _____ classifications of layer differences in the fetal/maternal interface.
Definition
four
Term
Epitheliochorial Placentation
Definition
all layers (6) intact
Term
Synepitheliochorial Placentation
Definition
fusion of binucleate trophoblasts & endometrial epithelium that form syncitial plaques
Term
Endotheliochorial Placentation
Definition
the endometrial epithelium is lost
Term
Hemochorial Placentation
Definition
endometrial epithelium & endothelium is lost
Term
Pig's have:
Definition
epitheliochorial placentation
Term
Horses have:
Definition
epitheliochorial placentation
Term
Cows have:
Definition
epitheliochorial placentation
Term
Sheep & goats have:
Definition
synepitheliochorial placentation
Term
Dogs & cats have:
Definition
endotheliochorial placentation
Term
Primates & rodents have:
Definition
hemochorial placentation
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